<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19642

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMNKYGFDSITRDPTKAITSRNGPTPQKPELPDSPLDRKVLAYASKELPEKVLYHSLRVYLYSVAIINDYFREWNLDKTVLFATCLLHDIGTTEKNMAATKMSFEFYGGFIAKEFIEEEAKDKTFAEAVCEAVIRHQDIGDSGNITTLGLILQIATILDNVGKHTQYIHPETLNYVNKKYSREGWLACFAASTDNENAKKPWGHTSKLGVPDFSEAILANPLASSWRKDYAKMPDLPSVSGIVTHFYKIAHLQLLEVHIYTATDPTQDQLLLELELHIRDQHPRILLTYYNKCLYQFKLGHIEAGVDLLKPGDTSSANHGRLDELYPKLTFKREFTVNAASLAKPSKGLSSQGTNKKDSEPLDDQLAFVSLTFFKAVKKMIVFNLCQNSNNYLFGNYLASQIQGDSSRLTVIQIDPVVLENGDLIVSLFQTNRLDLWFSSVIQLSASSMSLTKNFVIYVIPSGLRCHLYDTSDYHLTFTLSPPKSSSNLLRLLKLSTGIDLSKREEILWAKLIPNLQHLNNQTSNISHFIHEVDNKKFILWPWELCLLQFGDESTSETALASPSCNTDPMDLLNRFMDFSIASKERHLHSKGESFLPDVPISTAPQFSQNSSANGVSPISTGKSSGNAAFMDDTSVKLETPVMSMTDDLSYQDFHQTPSANSVKPELSDVPKWNEERLETREAAASEKFHSDLPKVKILGDNEKEGENVGDDDDDDDLFGESSGSEVNDENVAKPNAKSDLLVTDADSNPIVSKLSDAEELSANHVAKEGADSAYNRVSTPGLDSPSTFVNIPRDQMISDKDIGSYKDPGAPLPIIPTPVVPASAVFTPSISASEKSFFKREKRPTNDRPPENAAVKEGTGYVFSPIRFNPVIKSSIDTKYGKGGKFYVEHDEASDPEHRNRRFRETSVSHGSPLQFSNELAARQNDMSKTSERKAKKQPIEGNPEENSSFTSKELSAPIKDQEIDFEVQEAAQSGMPDHQVGRRVENEYPQDGSASIDCHPYRRSHGKDDDDDLGEDDDDDDDDAMEDSMNEEDEEEDEEESDEDEEYGNEDLDTSPLRLNTLNQDPTIVGHNSLNETVRPFPPANSNIDMAQQDLSPYPSGHRQWGGKDEIPPGPAGPVLINDPVTQSLSPLPIYPNDTKEELAIISNDSKDIDTSIPATSAGSPVTSTSSAVGESSNCLPLILRSINVLTIPPVFFLRKEQESWDAVTMLSGFDMDVVEDYESLDVERYHALTVKGKDLAEFLKWITSNLIFDFGNFEARHTTRSKISEEDHFYHDGPCVETEPSELMLKIFKSVFPLSLRVSLDELRFGYSETNIESSKKIDENTVDNHLGFLGQLNEGNENDLPDIKSIFWDSIYHESPENERNAELYTKHLTEAEQRWSSRKNEDHATLPTSDAKVKILKPNSEIINIDFVGLRFWRYLNLKPVNHERTFQVLLISPTTTGAFDNDVFERGNLSFLSLLKNNYKNNHFGDIKKLSLLAPENRADLEGVSNGTILLEQSEAECGYTKFYHRLGKRLRALAELIKLDLINKNNRFDFDRPLLLLFINFDDTIGSISQLSKICRDFQASLNIHQLSLVEVLSHVIPWQSILKLANNRRRLKYLSSAELTNLSMMLYNKCPNSRMRYSTQTTRGTAGLFTRLLKERPQSLNFKVSNRRLYNDDGATLAEDLFLHVAYERSIDRKWVSAAWSDPHGVVTYTKSWYCASKRGDNTNGQDIGQIISELWDTSSSLLKYLGDEESRSACGTSGKRFLVLTRVNSILPDDELVFWKRLTSKYKEISLIVLSANRLPKITFGYQGKGATNAPMGEQSPANPDQMAVNKSYNMCGLGGTDLIKAFPIPYTSSPGTNEINNIASPINSSTLHVHSPHQFVNAPGNFLSPQDSGVQSHNGESNIIDEHNLYIRDKNLDVVGFVPQTSLPCSNSPTRLGMKTGYLIKEIGDEESTNFMTFEVSLLSCSSQWNLNTIMKILLNQFKKLIHLNYIIGICPLTNKDETTSSAHRTKLRSMTPWHINAIGKSLDYLVHVSVNDDV
Length2032
PositionKinase
Organism[Candida] pseudohaemulonis
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Metschnikowiaceae> Clavispora> Clavispora/Candida clade.
Aromaticity0.08
Grand average of hydropathy-0.506
Instability index44.42
Isoelectric point5.14
Molecular weight227742.17
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP19642
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     745.31|     232|     307|     581|     877|       1
---------------------------------------------------------------------------
  581-  833 (348.09/311.79)	ASKERHlhsKGESFlPDVPIS.TAP.QFSQNSSA..NGVS..........PIsTGKSSGNAAFmddTSVKLETPVmsmTDdlSYQDFHQTPSANSVKPElSDVPKWNEERLeTREAAASEKFHsdlPKVKILG..DNEKEGENvgDDDDDDDLFGESSGSEVNDENVAKPNAKSDLLVTD.ADSNP...........IV.....SKLSDAEELSANHVAKEGADSAYNRVS...............TPGLDSPSTFVNIPRDQMISDKDIGSYKDPGaPLPIIPTPV.................VPASAVFTPSISAS
  893- 1171 (333.18/182.57)	ASDPEH...RNRRF.RETSVShGSPlQFSNELAArqNDMSktserkakkqPI.EGNPEENSSF...TSKELSAPI...KD..QEIDFEVQEAAQSGMPD.HQVGRRVENEY.PQDGSASIDCH...PYRRSHGkdDDDDLGED..DDDDDDDAMEDSMNEEDEEEDEEESDEDEEYGNED.LDTSPlrlntlnqdptIV.....GHNSLNETVRPFPPANSNIDMAQQDLSpypsghrqwggkdeiPPGPAGP.VLINDPVTQSLS............PLPIYPNDTkeelaiisndskdidtsIPATSAGSPVTSTS
 1808- 1892 (64.04/14.48)	.........................................................................................................................................................MGEQSPANPDQMAVNKSYNMCGLGGTDlIKAFP...........IPytsspGTNEINNIASPI...........NS.S...............TLHVHSPHQFVNAP.GNFLSPQDSGVQSHNG.........................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     174.44|      58|      63|    1475|    1537|       2
---------------------------------------------------------------------------
 1475- 1537 (84.17/81.43)	DIKKLSLLAPENRADLEG.VSNGTILLEQSEAECGytkfYHRLgKRLRALAELIKLDLINK..NNR
 1539- 1599 (90.27/69.00)	DFDRPLLLLFINFDDTIGsISQLSKICRDFQASLN....IHQL.SLVEVLSHVIPWQSILKlaNNR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     120.99|      38|    1463|     471|     519|       3
---------------------------------------------------------------------------
  471-  519 (53.40/52.65)	SDYHLTFTLSppksssnllrLLKLSTGIDLSKREEILWAKLiPNLQHLN
 1945- 1982 (67.59/39.73)	STNFMTFEVS..........LLSCSSQWNLNTIMKILLNQF.KKLIHLN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     319.32|     104|    1326|     289|     408|       4
---------------------------------------------------------------------------
  289-  408 (159.98/127.83)	YNKC.....LYQFKLGHIEAGV..DLLKPgdtssanhgRLDELYPKLTFKREFTVNAASLAKP..SKGLSSQGTNKK.DSEPLDDQLAFVSLT..FFKAVKKmivfnlCQNSNNYLFGNyLASQIQGDSSRL
 1618- 1733 (159.33/95.29)	YNKCpnsrmRYSTQTTRGTAGLftRLLKE.........RPQSLNFKVSNRRLYNDDGATLAEDlfLHVAYERSIDRKwVSAAWSDPHGVVTYTksWYCASKR......GDNTNGQDIGQ.IISELWDTSSSL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19642 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FHSDLPKVKILGDNEKEGENVGDDDDDDDLFGESSGSEVNDENVAKPNAKSDLLVTDADSNPIVSKLSDAEELSANHVAKEGADSAYNRVSTPGLDSPSTFVNIPRDQ
2) GGKFYVEHDEASDPEHRNRRFRETSVSHGSPLQFSNELAARQNDMSKTSERKAKKQPIEGNPEENSSFTSKELSAPIKDQEIDFEVQEAAQSGMPDHQVGRRVENEYPQDGSASIDCHPYRRSHGKDDDDDLGEDDDDDDDDAMEDSMNEEDEEEDEEESDEDEEYGNEDLDTSPLRLNTLNQDPTIVGHNSLNETVRPFPPANSNIDMAQQDLSPYPSGHRQWGGKDEIPPGPAGPVLINDPVTQSLSPLPI
3) PVMSMTDDLSYQDFHQTPSANSVKPELSDVPKWNEERLETREAAASE
4) QFSQNSSANGVSPISTGKSSGNAAFMDDTSVKLE
688
883
640
605
795
1135
686
638










Molecular Recognition Features






MoRF SequenceStartStop




1) GTGYVFSP
2) IDCHPYRR
3) KFYVEH
4) MNKYG
5) SISASEKSFFKREKRP
858
997
885
1
829
865
1004
890
5
844