<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19642

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMNKYGFDSITRDPTKAITSRNGPTPQKPELPDSPLDRKVLAYASKELPEKVLYHSLRVYLYSVAIINDYFREWNLDKTVLFATCLLHDIGTTEKNMAATKMSFEFYGGFIAKEFIEEEAKDKTFAEAVCEAVIRHQDIGDSGNITTLGLILQIATILDNVGKHTQYIHPETLNYVNKKYSREGWLACFAASTDNENAKKPWGHTSKLGVPDFSEAILANPLASSWRKDYAKMPDLPSVSGIVTHFYKIAHLQLLEVHIYTATDPTQDQLLLELELHIRDQHPRILLTYYNKCLYQFKLGHIEAGVDLLKPGDTSSANHGRLDELYPKLTFKREFTVNAASLAKPSKGLSSQGTNKKDSEPLDDQLAFVSLTFFKAVKKMIVFNLCQNSNNYLFGNYLASQIQGDSSRLTVIQIDPVVLENGDLIVSLFQTNRLDLWFSSVIQLSASSMSLTKNFVIYVIPSGLRCHLYDTSDYHLTFTLSPPKSSSNLLRLLKLSTGIDLSKREEILWAKLIPNLQHLNNQTSNISHFIHEVDNKKFILWPWELCLLQFGDESTSETALASPSCNTDPMDLLNRFMDFSIASKERHLHSKGESFLPDVPISTAPQFSQNSSANGVSPISTGKSSGNAAFMDDTSVKLETPVMSMTDDLSYQDFHQTPSANSVKPELSDVPKWNEERLETREAAASEKFHSDLPKVKILGDNEKEGENVGDDDDDDDLFGESSGSEVNDENVAKPNAKSDLLVTDADSNPIVSKLSDAEELSANHVAKEGADSAYNRVSTPGLDSPSTFVNIPRDQMISDKDIGSYKDPGAPLPIIPTPVVPASAVFTPSISASEKSFFKREKRPTNDRPPENAAVKEGTGYVFSPIRFNPVIKSSIDTKYGKGGKFYVEHDEASDPEHRNRRFRETSVSHGSPLQFSNELAARQNDMSKTSERKAKKQPIEGNPEENSSFTSKELSAPIKDQEIDFEVQEAAQSGMPDHQVGRRVENEYPQDGSASIDCHPYRRSHGKDDDDDLGEDDDDDDDDAMEDSMNEEDEEEDEEESDEDEEYGNEDLDTSPLRLNTLNQDPTIVGHNSLNETVRPFPPANSNIDMAQQDLSPYPSGHRQWGGKDEIPPGPAGPVLINDPVTQSLSPLPIYPNDTKEELAIISNDSKDIDTSIPATSAGSPVTSTSSAVGESSNCLPLILRSINVLTIPPVFFLRKEQESWDAVTMLSGFDMDVVEDYESLDVERYHALTVKGKDLAEFLKWITSNLIFDFGNFEARHTTRSKISEEDHFYHDGPCVETEPSELMLKIFKSVFPLSLRVSLDELRFGYSETNIESSKKIDENTVDNHLGFLGQLNEGNENDLPDIKSIFWDSIYHESPENERNAELYTKHLTEAEQRWSSRKNEDHATLPTSDAKVKILKPNSEIINIDFVGLRFWRYLNLKPVNHERTFQVLLISPTTTGAFDNDVFERGNLSFLSLLKNNYKNNHFGDIKKLSLLAPENRADLEGVSNGTILLEQSEAECGYTKFYHRLGKRLRALAELIKLDLINKNNRFDFDRPLLLLFINFDDTIGSISQLSKICRDFQASLNIHQLSLVEVLSHVIPWQSILKLANNRRRLKYLSSAELTNLSMMLYNKCPNSRMRYSTQTTRGTAGLFTRLLKERPQSLNFKVSNRRLYNDDGATLAEDLFLHVAYERSIDRKWVSAAWSDPHGVVTYTKSWYCASKRGDNTNGQDIGQIISELWDTSSSLLKYLGDEESRSACGTSGKRFLVLTRVNSILPDDELVFWKRLTSKYKEISLIVLSANRLPKITFGYQGKGATNAPMGEQSPANPDQMAVNKSYNMCGLGGTDLIKAFPIPYTSSPGTNEINNIASPINSSTLHVHSPHQFVNAPGNFLSPQDSGVQSHNGESNIIDEHNLYIRDKNLDVVGFVPQTSLPCSNSPTRLGMKTGYLIKEIGDEESTNFMTFEVSLLSCSSQWNLNTIMKILLNQFKKLIHLNYIIGICPLTNKDETTSSAHRTKLRSMTPWHINAIGKSLDYLVHVSVNDDV
Length2032
PositionKinase
Organism[Candida] pseudohaemulonis
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Metschnikowiaceae> Clavispora> Clavispora/Candida clade.
Aromaticity0.08
Grand average of hydropathy-0.506
Instability index44.42
Isoelectric point5.14
Molecular weight227742.17
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP19642
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     745.31|     232|     307|     581|     877|       1
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  581-  833 (348.09/311.79)	ASKERHlhsKGESFlPDVPIS.TAP.QFSQNSSA..NGVS..........PIsTGKSSGNAAFmddTSVKLETPVmsmTDdlSYQDFHQTPSANSVKPElSDVPKWNEERLeTREAAASEKFHsdlPKVKILG..DNEKEGENvgDDDDDDDLFGESSGSEVNDENVAKPNAKSDLLVTD.ADSNP...........IV.....SKLSDAEELSANHVAKEGADSAYNRVS...............TPGLDSPSTFVNIPRDQMISDKDIGSYKDPGaPLPIIPTPV.................VPASAVFTPSISAS
  893- 1171 (333.18/182.57)	ASDPEH...RNRRF.RETSVShGSPlQFSNELAArqNDMSktserkakkqPI.EGNPEENSSF...TSKELSAPI...KD..QEIDFEVQEAAQSGMPD.HQVGRRVENEY.PQDGSASIDCH...PYRRSHGkdDDDDLGED..DDDDDDDAMEDSMNEEDEEEDEEESDEDEEYGNED.LDTSPlrlntlnqdptIV.....GHNSLNETVRPFPPANSNIDMAQQDLSpypsghrqwggkdeiPPGPAGP.VLINDPVTQSLS............PLPIYPNDTkeelaiisndskdidtsIPATSAGSPVTSTS
 1808- 1892 (64.04/14.48)	.........................................................................................................................................................MGEQSPANPDQMAVNKSYNMCGLGGTDlIKAFP...........IPytsspGTNEINNIASPI...........NS.S...............TLHVHSPHQFVNAP.GNFLSPQDSGVQSHNG.........................................
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     174.44|      58|      63|    1475|    1537|       2
---------------------------------------------------------------------------
 1475- 1537 (84.17/81.43)	DIKKLSLLAPENRADLEG.VSNGTILLEQSEAECGytkfYHRLgKRLRALAELIKLDLINK..NNR
 1539- 1599 (90.27/69.00)	DFDRPLLLLFINFDDTIGsISQLSKICRDFQASLN....IHQL.SLVEVLSHVIPWQSILKlaNNR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     120.99|      38|    1463|     471|     519|       3
---------------------------------------------------------------------------
  471-  519 (53.40/52.65)	SDYHLTFTLSppksssnllrLLKLSTGIDLSKREEILWAKLiPNLQHLN
 1945- 1982 (67.59/39.73)	STNFMTFEVS..........LLSCSSQWNLNTIMKILLNQF.KKLIHLN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     319.32|     104|    1326|     289|     408|       4
---------------------------------------------------------------------------
  289-  408 (159.98/127.83)	YNKC.....LYQFKLGHIEAGV..DLLKPgdtssanhgRLDELYPKLTFKREFTVNAASLAKP..SKGLSSQGTNKK.DSEPLDDQLAFVSLT..FFKAVKKmivfnlCQNSNNYLFGNyLASQIQGDSSRL
 1618- 1733 (159.33/95.29)	YNKCpnsrmRYSTQTTRGTAGLftRLLKE.........RPQSLNFKVSNRRLYNDDGATLAEDlfLHVAYERSIDRKwVSAAWSDPHGVVTYTksWYCASKR......GDNTNGQDIGQ.IISELWDTSSSL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19642 with Med13 domain of Kingdom Fungi
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