<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19628

Description Mediator of RNA polymerase II transcription subunit 7
SequenceMAAQAPPAAQQAPQQQALYPPPPPFYRLYRPGADGSVDAPLPPPPVEGAYQQFGIADSTEVVLPPLTGRQLFEAGPDGAIDFRGELLALHRELVAQVLELLAVLTDKPSMWARQVENTSAVLRNMQHLCNLLRPVQARQTLLHTLRGELEQRQAAAQELRDVAAAADAALAGSAEELAAAAAALQQAAEAAGGVAAANGAG
Length201
PositionMiddle
OrganismMicractinium conductrix
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Chlorophyta> core chlorophytes> Trebouxiophyceae> Chlorellales> Chlorellaceae> Chlorella clade> Micractinium.
Aromaticity0.04
Grand average of hydropathy-0.075
Instability index41.47
Isoelectric point4.81
Molecular weight21017.54
Publications
PubMed=29178410

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP19628
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      98.14|      19|      19|      20|      38|       1
---------------------------------------------------------------------------
   20-   38 (39.54/17.83)	P.PPPPFYRLYRP.GADGSVD
   40-   60 (26.14/ 9.78)	PlPPPPVEGAYQQfGIADSTE
   63-   81 (32.46/13.58)	L.PPLTGRQLFEA.GPDGAID
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.83|      22|      23|     145|     166|       2
---------------------------------------------------------------------------
  145-  166 (35.90/19.14)	LRGELEQRQAAAQELRDVAAAA
  170-  191 (33.93/17.66)	LAGSAEELAAAAAALQQAAEAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.72|      17|      23|      97|     114|       3
---------------------------------------------------------------------------
   97-  114 (26.32/19.21)	VLELLAVLTD........KPsMWARQ
  115-  139 (22.40/11.58)	VENTSAVLRNmqhlcnllRP.VQARQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19628 with Med7 domain of Kingdom Viridiplantae
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