<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19623

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMEAAPTAISGLHLVPFRDVLENVVVDAQAELQALAERLPALGDEERKRQLLLHLQATRQRLQRLHVCAQWAHKAKAVNTCREVLKAAQDHGAAFVHTADELFRLHEELRFSRAPLFDVSTALHISQTGTYRLLPRVIEDELQQPGQRLERPVEVDEAARSARSRDALRRLDFLLRSKLLTSDLPAGLRVLRVRGGQAAVAAAGGQYTAALTLVPAPRDDVTLTKYRPPGEAEAAAVKEEVTQPVAAAEQPSTSAAAAPPAASPAAGYAAAQQRQGADAWRWQLLSFELLPAAAAHDPPPLLPAQRTWLQQHIEQRMWAAADVEQLARLGKQAWVTVPEPPGVGKQAVGTAGKASSAPAPSASLAPSHLAAAAGTAAAAQAAAAAAADAKGKAPVKEEPEEHAAGAAVGEAAAATAAAAEGPRLPAHAVNPLAAMHAILCQTAGRLALFSLLLGDARQLEGGSWKGRLKLSRASSGTGLRFAYWQQVPCVSYAELQCLREGRPYQAETATAAGAAAAGPGPGSAAGASAQQQQQQQQQQAAAPQEQQAPAVDVELQGDGGLAASSSPQLRHALTGKEVQLALPLDSAASLDADRLLLTAAAHSAAAQLAAVQAEAQRGGRLAAAGNHAELSVPAVAASGAGPLPASPQLLLWSGGSLQLSLSVQLRAGRLLLLAGPALLESEQSGEAAAAVAAAQQQLDAAQRDATTQPLPAGCTRGMLAARLAGDVLTRLSVQLSMRRRMDAAAAAAAACGLRRTALPPQLLDQHFREAPPLLAPLSRNTLTLALPAFPPPHDMQRWARQQQQRQRQGVPVGSGAVRCFLLVDYGEPGAAAAAAAAGREGGGAAGSDAAAAELGGAAEQEAARMLLAVCACTSRGTVTRVLQLAPVPLQVAAAVQPPRGAAAASRKRRASDAAAEGALREQQAVGGSDGEHVALEAAAAWCRRQAGWEALRAQLLLLPVQHAEELPLATLPQQQQQVIRLPSAPVLARLEAWAAGQLAAAGGDGATVGAPKPRPAAVLQLEGGGGGAWRVDLASAYFARLPALLAQQGVLLAAPAPDAQHMAAHAAGLSLRYSLAAGHSVLAAISDLVRLGMLHLCLTRLAGCMAANPLAAGGTAKAGGGGGGANGSLVVGAPACNGPTNGSLANGGPQLDGVNGSAGGASLVWPLPGCGSVRLVEAGLTHFVLAVAPPQQPESAAKAGQPAPARLTVSWDNTLLSDGSGGGGAASAAAKESPAAQQPRGDGGGPAATAPPPAAQAGGLLRHIRCSVASEPPLPEPVAAALAQQLEAGRADLFLDSLCLAAHAAAAAQRQLAPEAQRAAGLLPGALRVAGAGGSAGGSADVASAGSSALRLRAQLQQGGRAASLCLGFHAGGYTLVQLAPGLGGTAAAGAHAWLPALWDRLSQSVPTFAAVTPDPPKPSPGQPGEQQQQQQQVVLRQAWVHHSGLGAALAGIAQAVAAPAAA
Length1462
PositionTail
OrganismMicractinium conductrix
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Chlorophyta> core chlorophytes> Trebouxiophyceae> Chlorellales> Chlorellaceae> Chlorella clade> Micractinium.
Aromaticity0.03
Grand average of hydropathy-0.001
Instability index51.08
Isoelectric point8.48
Molecular weight148060.07
Publications
PubMed=29178410

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP19623
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            11|     951.95|     111|     112|    1112|    1222|       1
---------------------------------------------------------------------------
  173-  265 (62.50/ 7.71)	LLRSKLLtSDlPAG..........lrvlrV.R...........G...G.....QAAVAAAG............GqyTAA...LTL.....VPAP................................................................................rddvtltkyrpP.GE..A..EA...A...A...VKEEVTQ............PVAA.AEQ...PS....TSAAAA....P..P...........AasP..A...A
  340-  431 (82.05/12.97)	...........................................P...G.....VGKQAVGT............A..GKA...SS........APA..............................................PS.ASLAPS...HL.AAAAGTAAAaqAAAAAAA...........D.AK..G..KA...P...V...KEEPEEHAAgA........AVGE.AAA...AT....AAAAEG....PrlP...........A..H..AVNPL
  432-  549 (85.79/13.98)	AAMHAIL.CQ.TAGrlalfslllgdarqlE.G...........GswkGrlklsRASSGTGL............R..FAY...WQQ....V...PCV...........................................SYAELQCLREGRPyQA.ET..ATAAG..AAAAGPG...........P.GS..A.................AG...............ASAQ.QQQ...QQqqqqAAAPQE....Q..Q...........A..P..A....
  550-  623 (56.60/ 6.12)	.VDVELQ.GD...................G.G...........................................lAAS...SS...................................................................P.QLrHALTGKE....VQLALPL...........D.SA..A..SLdadR...L...LLTAAAHSA.A........AQLA.AVQ...AE.....AQRGG....R..L...........A..A..A....
  672-  755 (71.29/10.07)	LAGPALLeSE.QSG...............E.A...............................................................................................................AAAVAAAQQ.QL.DAAQRDA......TTQPL...........PaGCtrGmlAA...R...L...AGDVLTRLS.V........QLSM.RRR...MD....AAAAAA....A..A...........C..G..LRRT.
  756-  838 (73.67/10.72)	ALPPQLL.DQ.....................................................hfreappllaP..LSR...NTL....TLALPAF...........................................PPPHDMQRWARQQ.QQ.RQRQGV..........PV.............GS..G..AV...RcflL...VDYG..................E.PGA...AA....AAAAAG....R.........................
  839-  990 (64.90/ 8.35)	.........E.GGG...............A.A...........G...S.....DAAAAELG............G..AAEqeaARM....LLAVCACtsrgtvtrvlqlapvplqvaaavqpprgaaaasrkrrasdaaaEGALREQQAVGGS.DG.EHVALEAAA..A...WCR...........R.QA..G...............WEALRAQLL.L..........LP.VQH...AE....ELPLAT....L..PqqqqqvirlpsA..PvlARLE.
  991- 1100 (85.58/13.92)	AWAAGQL.AA.AGG...............D.GatvgapkprpaA...V.....LQLEGGGG............G..AWR...VDLasayFARLPAL...........................................LAQQGVLLAAPAP.DA.QHMAAHAAG..LSLRYSL...........A.AG..H..SV...L.........AAISDLV..............................RLG..mlH..L...........C..L..TRL..
 1101- 1208 (161.57/34.39)	............AG...............C.M....aanplaaG...G.....TAKAGGGG............G..GAN...GSL....VVGAPAC...........................................NGPTNGSLANGGP.QL.DGVNGSAGG..ASLVWPL...........P.GC..G..SV...R...L...VEAGLTHFV.L........AVAP.PQQ...PE....SAAKAG....Q..P...........A..P..ARLTV
 1209- 1328 (110.28/20.58)	SWDNTLL.SD.GSG...............G.G..gaasaaakeS...P.....AAQQPRGD............G..GG...............PAA...........................................TAPPPA..AQAGG.LL.RHIRCSV....ASE.PPL...........P.EP..V..AA...A...LaqqLEAGRADLF.LdslclaahAAAA.AQRqlaPE.....AQRAA....G..L...........L..P..GALRV
 1329- 1437 (97.71/17.19)	........A..GAG...............GsA...........G...G.....SADVASAGssalrlraqlqqG..GRA...ASL....CLGFHA............................................GGYTLVQLA...P.GL.GGT..AAAG..AH.AW.L...........P.AL..W..D....R...L....SQSVPTFA..........AVTPdPPK...P.....SPGQPGeqqqQ..Q...........Q..Q..VVLRQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.77|      32|     112|       6|      44|       2
---------------------------------------------------------------------------
    6-   44 (40.65/45.85)	TAisgLHLV...PFRdVLENVVVDaqaELQALAERL..PALGDE
  120-  156 (48.13/29.86)	TA...LHISqtgTYR.LLPRVIED...ELQQPGQRLerPVEVDE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19623 with Med14 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AVAPPQQPESAAKAGQPAPARLTVSWDNTLLSDGSGGGGAASAAAKESPAAQQPRGDGGGPAATAPPPAAQ
2) LGKQAWVTVPEPPGVGKQAVGTAGKASSAPAPSASLAP
3) RDDVTLTKYRPPGEAEAAAVKEEVTQPVAAAEQPSTSAAAAPPAASPAAGYAA
4) TATAAGAAAAGPGPGSAAGASAQQQQQQQQQQAAAPQEQQAPAVDVELQGDGGLAASSSPQ
1185
328
217
507
1255
365
269
567










Molecular Recognition Features






MoRF SequenceStartStop




NANANA