<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19622

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMEAAPTAISGLHLVPFRDVLENVVVDAQAELQALAERLPALGDEERKRQLLLHLQATRQRLQRLHVCAQWAHKAKAVNTCREVLKAAQDHGAAFVHTADELFRLHEELRFSRAPLFDVSTALHISQTGTYRLLPRVIEDELQQPGQRLERPVEVDEAARSARSRDALRRLDFLLRSKLLTSDLPAGLRVLRVRGGQAAVAAAGGQYTAALTLVPAPRDDVTLTKYRPPGEAEAAAAVKEEVTQPVAAAEQPSTSAAAAPPAASPAAGYAAAQQRQGADAWRWQLLSFELLPAAAAHDPPPLLPAQRTWLQQHIEQRMWAAADVEQLARLGKQAWVTVPEPPGVGKQAVGTAGKASSAPAPSASLAPSHLAAAAGTAAAAQAAAAAAADAKGKAPVKEEPEEHAAGAAVGEAAAATAAAAEGPRLPAHAVNPLAAMHAILCQTAGRLALFSLLLGDARQLEGGSWKGRLKLSRASSGTGLRFAYWQQVPCVSYAELQCLREGRPYQAETATAAGAAAAGPGPGSAAGASAQQQQQQQQQQAAAPQEQQAPAVDVELQGDGGLAASSSPQLRHALTGKEVQLALPLDSAASLDADRLLLTAAAHSAAAQLAAVQAEAQRGGRLAAAGNHAELSVPAVAASGAGPLPASPQLLLWSGGSLQLSLSVQLRAGRLLLLAGPALLESEQSGEAAAAVAAAQQQLDAAQRDATTQPLPAGCTRGMLAARLAGDVLTRLSVQLSMRRRMDAAAAAAAACGLRRTALPPQLLDQHFREAPPLLAPLSRNTLTLALPAFPPPHDMQRWARQQQQRQRQGVPVGSGAVRCFLLVDYGEPGAAAAAAAAGREGGGAAGSDAAAAELGGAAEQEAARMLLAVCACTSRGTVTRVLQLAPVPLQVAAAVQPPRGAAAASRKRRASDAAAEGALREQQAVGGSDGEHVALEAAAAWCRRQAGWEALRAQLLLLPVQHAEELPLATLPQQQQQVIRLPSAPVLARLEAWAAGQLAAAGGDGATVGAPKPRPAAVLQLEGGGGGAWRVDLASAYFARLPALLAQQGVLLAAPAPDAQHMAAHAAGLSLRYSLAAGHSVLAAISDLVRLGMLHLCLTRLAGCMAANPLAAGGTAKAGGGGGGANGSLVVGAPACNGPTNGSLANGGPQLDGVNGSAGGASLVWPLPGCGSVRLVEAGLTHFVLAVAPPQQPESAAKAGQPAPARLTVSWDNTLLSDGSGGGGAASAAAKESPAAQQPRGDGGGPAATAPPPAAQAGGLLRHIRCSVASEPPLPEPVAAALAQQLEAGRADLFLDSLCLAAHAAAAAQRQLAPEAQRAAGLLPGALRVAGAGGSAGGSADVASAGSSALRLRAQLQQGGRAASLCLGFHAGGYTLVQLAPGLGGTAAAGAHAWLPALWDRLSQSVPTFAAVTPDPPKPSPGQPGEQQQQQQQVVLRQAWVHHSGLGAALAGIAQAVAAPAAA
Length1463
PositionTail
OrganismMicractinium conductrix
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Chlorophyta> core chlorophytes> Trebouxiophyceae> Chlorellales> Chlorellaceae> Chlorella clade> Micractinium.
Aromaticity0.03
Grand average of hydropathy0.000
Instability index51.05
Isoelectric point8.48
Molecular weight148131.15
Publications
PubMed=29178410

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP19622
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            10|     978.99|     111|     112|    1113|    1223|       1
---------------------------------------------------------------------------
  268-  409 (108.65/21.71)	YAAA..QQRQG....A............DAWR...WQL....LsfelLPAAAA...........................................HDPP..P.LL.P......A..qrtwlqqhieqrmwaaadveqlarlgkqawvtvPEP.PGVGkqavGT.AGKASSA.PAP...SA...S...L...APS...HLAA........AAGT.AAA...A.QAAA.....AAA....AD...........AK..GKAPVKEEPEEH.AAGAAV.G
  413-  522 (87.15/15.42)	AATA..AAAEGprlpA............HAVN...PLA....A....MHAILC...........................................Q..T..AGRL.AlfslllGDA.................................RQL.EG......GSwKGRLKLSRASSGTG......................L........RFAY.WQQ..vPcVSYAelqclREG....RP...........YQ..AETATAAGAA...AAGPGP.G
  526-  624 (70.39/10.51)	GASAqqQQQQQ....Q............QQAA...APQ....E....QQAPAV...........................................DVELqgDGGLaA......SSS.................................PQLrHALT....GK.E..VQLALPLDSAASLdadR...L...LLTAAAHSAA........AQLA.AVQ...A.E.AQ.....RGG....RL...........AA..A....................
  625-  687 (74.62/11.75)	.............................GNH...AEL....S....VPAVAA...........................................SG....AGPL.P.......AS.................................PQL.................LLW..SG.GSL...Q...L...........SL........SV.....Q........L.....RAG......................RLLLLAGPALLeSEQSGE.A
  776-  845 (77.98/12.73)	............................PLSR...NTL....T....LALPAF...........................................PPPH..DMQR.W......ARQ.................................QQQ.RQRQ....GV.........PV.GSGAV...RcflL...VDYG.................E.PGA...A.AAAA.....AAG....R..............................EGGGA.A
  846- 1005 (87.85/15.62)	GSDA..AAAEL....G............GAAEqeaARM....L....LAVCACtsrgtvtrvlqlapvplqvaaavqpprgaaaasrkrrasdaaaEGAL..REQQ.A......VGG.................................SDG.EHVA....LE.AAAA...WCRRQAG.............WEALRAQLLL..........LP.VQH...A.EELP.....LAT....LPqqqqqvirlpsAPvlARLE.AWAAGQL.AAAGGD.G
 1017- 1105 (87.91/15.64)	AVLQ..LEGGG....G............GAWR...VDLasayF....ARLPAL...........................................LAQQ..GVLL.A......APA.................................PDA.QHMA....AH.AAGLSLRYSLAAGHSV...L.........AAISDLV...............................RLG..mlHL...........CL..TRL.............AGC.M
 1113- 1223 (189.06/45.26)	GGTA..KAGGG....G............GGAN...GSL....V....VGAPAC...........................................NGPT..NGSL.A......NGG.................................PQL.DGVN....GS.AGGASLVWPLPGCGSV...R...L...VEAGLTHFVL........AVAP.PQQ...P.ESAA.....KAG....QP...........AP..ARLTVSWDNTLL.SDGSGG.G
 1233- 1336 (103.82/20.30)	SPAA..QQPRG....D............GGG...................PAA...........................................TAPP..PA...A......QAG.................................GLL.RHIR....CS.V..ASE.PPLPEPVAA...A...LaqqLEAGRADLFLdslclaahAAAA.AQRqlaP.E.AQ.....RAA....GL...........LP..GALRV........A.GAGGsA
 1337- 1440 (91.57/16.71)	GGSA..DVASA....GssalrlraqlqqGGRA...ASL....C....LGFHA............................................GGYT..LVQL.A..........................................PGL.GGT......A.AAGAH.AW.LPALWD....R...L....SQSVPTFA.........AVTPdPPK...P..SPG.....QPGeqqqQQ...........QQ..VVLRQAW..............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.66|      25|      38|      11|      35|       2
---------------------------------------------------------------------------
   11-   35 (41.16/27.05)	LHLVPFRDVLENVVVDAQAELQALA
   52-   76 (45.50/30.83)	LHLQATRQRLQRLHVCAQWAHKAKA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.09|      16|      31|     213|     228|       4
---------------------------------------------------------------------------
  213-  228 (29.65/14.97)	VPAPRDDVTLTKYRPP
  245-  260 (26.44/12.45)	VAAAEQPSTSAAAAPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.98|      12|     453|     233|     244|       5
---------------------------------------------------------------------------
  233-  244 (19.56/ 8.89)	AAAAVKEEVTQP
  698-  709 (20.42/ 9.70)	LDAAQRDATTQP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19622 with Med14 domain of Kingdom Viridiplantae
Unable to open file!