<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19620

Description Mediator of RNA polymerase II transcription subunit 4
SequenceMAAAADGRSVGRLPPNETALLVCDVQERFRPVISGFPAVVDTSWAAHAEVELAVLLQRLQGLLRDSAKPDSAGLDGLLEELAWLFSSLSGSKGADEAFRAIDNAQGKLQAAIVALQGAVDRYTPPPGYRPPAADAADAAFVRGLLSYAHRLSYSSAAPLGYQPGQPLYFFKPPAPQEAEMRVSQLHAFSREWEAQQQQLQAQRAAAARGAAAPTAAPAAVPAAMPAAPAAAPPGDLAGLAAQHGLDVQHLLASMPPGWKPGDPIPAAGAAGAAAAAAAGAAPAAAAPQPEAAEEAAPPAPRLAGIFLNTLDLGELEYGSFSQKFRDWAARWAAGGAHEYVVQCCDEAEWASYRQLLAFMHSMAKELPQGPDELLRLLVVAREHAVEAAVLGCVQRLQEQACNLPACTCMELLAALLDAPVSGEAAIQAAAAQLTGACCDRMGELLKAEDVLQDAGEQRALVQLLGPLQVMLNDERLCQLWRALPLRLLRDCVLDDNNVQADTEATVLAACLRWAEGRAGLRVEQLAELLCRVRFPQVPAATLFNYHRAYTELRRFDPDKELLLRATSDPRQWDRLRAAMLAADPPPHIAAIKAKCERWWQPHVPPLARCAAPGSFGFQCRKPGDGSHSTSSNSVYWNGFLWRVMLKKKRAEDRVVAFLLPTASQKPCKGNSETLFGLEVYYEIFLCRGAEEDRVTAAWGRFTPTSGSGHGRHALTNRSAPGRPPFCWDDFWSDSASPYCRDGVVRGRFTLSVSADGSGASDGEERAANEQGW
Length772
PositionMiddle
OrganismMicractinium conductrix
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Chlorophyta> core chlorophytes> Trebouxiophyceae> Chlorellales> Chlorellaceae> Chlorella clade> Micractinium.
Aromaticity0.08
Grand average of hydropathy-0.147
Instability index42.97
Isoelectric point5.60
Molecular weight82763.97
Publications
PubMed=29178410

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP19620
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     362.55|      66|      69|     174|     239|       1
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   97-  139 (46.87/10.11)	..................................A.F.RAIDNAQGKLQAA......IVALQGAV............dRYTPPPGYRPPAAD...AADAA
  161-  230 (110.22/31.59)	YQ..PGQplyfFKPP.....APQEAEM.RVSQLHA.FSREWEAQQQQLQAQ.....RAAAARGAA.............APTAAPAAVPAAMP...AAPAA
  231-  295 (89.14/24.44)	AP..PGD....LAGL.....AAQHG.L.DVQHLLAsMPPGWKPG.DPIPAA.....GAAGAAAAA.............AAGAAPAA...AAPqpeAAEEA
  296-  365 (55.94/13.18)	AP..PAP...rLAGIflntlDLGELEYgSFSQ..K.F.RDW..................AARWAAggaheyvvqccdeAEWASYRQLLAFMH...SMAKE
  366-  431 (60.38/14.69)	LPqgPDE....LLRL...lvVARE.........HA.VEAAVLGCVQRLQEQacnlpACTCMELLA.............ALLDAPVSGEAAIQ...AAAA.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.83|      23|      44|     620|     642|       2
---------------------------------------------------------------------------
  620-  642 (46.40/32.25)	RKPGDGSHST.SSNSVYWNGFLWR
  664-  687 (40.43/27.16)	QKPCKGNSETlFGLEVYYEIFLCR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     122.15|      41|      83|     473|     513|       3
---------------------------------------------------------------------------
  473-  492 (24.28/ 7.49)	....................................DERLCQ....................LWR.ALPLR..LLRDCV
  493-  567 (44.37/20.12)	LDDNNVQADTE...ATVLAACLRWaegraglrveqlAELLCRvrfpqvpaatlfnyhrayteLRR.FDPDKelLLRATS
  575-  619 (53.50/25.86)	LRAAMLAADPPphiAAIKAKCERW...........wQPHVPP....................LARcAAPGS..FGFQC.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.44|      21|      45|     699|     719|       4
---------------------------------------------------------------------------
  699-  719 (39.95/24.18)	GRFT.PTSGSGHGRHALTNRSA
  746-  767 (32.49/18.31)	GRFTlSVSADGSGASDGEERAA
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19620 with Med4 domain of Kingdom Viridiplantae
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