<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19615

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMLGAVGRLFGFGSAAAGCGACDPEVLAKCSAPQPGDVKAHSHHVFVKLPAPSGSSGATDEGWWPESVDAEPTIKAVTTAIKEAGAAINGAVKVTAFDRLTSKALAPGSCDVLVLGAGAAGVGLQSVPLDRLPAVVLAALTGGDAAAAAGPDAQSSEDVADTVLVVCCHVARDERCGHIGPPLADKLAELAGTQAATGGVRVLKSSHIGGHKYAGNVIAYTRQDGAFQGNWFGGLNPGNANEFLTALFACKAPHGPAGDRVLRKYWRGCVGLSKEQQLERFEHGLKDIEDMGLPPAGQAAMEQPGAHQALDSLKLVPFRDVLENVCQEAHAGLQALADRLPALDDQQRKAELLQHLQTTQQRLQRLHVCAQWAHKAKAVNTCREVLKASQDHSAALVHAADEFFRLHEELRFVRAPLFDVGTALHILQSGNYRVLPSVIEEELVQPGQRLERPGEVPEVVAAEQQQAATRRIDFLLRSKLLTTELPPGLRVVRVRGGVATVAATGGQYTACLTLVPSPRDDVTLAKYRPPGEPEDAAAAAVKEEPEVTQPVAGPSAAAADGGQPSTSAAAAGPLAGGDADQRQGTDCWRWQLLSFELLPAAAGQDPPPLLAPQQQWLQQHVEQRMWVAADMEQLVRLGKQAWVTVPAAPKEQQEQGRASSAPAPTTSMAPSQLPAAADSKGKQPMAVDGEPEAPLGEQQGAAAAQLPAYAARPLAAMHAVLCQSAGRLALFSLLLSDARRLEGGSWKGGLKLSRAAAGAGIRLAYWLQLPSMGWQELQCLRDGTPFQPTPTGATAAATAGPQQQQQQQQQQQPEPPAVDVVVREDGNLAASSSPQLHHPLSGEAVQLPLPLDSAASFGADRLLLQAAACSAAVQLAAVQAVLQRRGHLAANGTHAELSLAAPLSPAAGAGVSEAPLPTSPSLLLWSSGSVQLSLGMQLRTGRLLLAAGPAVLESEQGSSAQAAVAAAQQQLDQLQRDALLQPLPPGTSRGMLAARLAADAVARLSLQLSVQRRMDAAAAAAAGFGMARAALPQRLLQQHMGTVSLLLAPLSGNTLTLALPAHQPPRDLARWASRQQAQQQQQGGGNGSGPGSVAESGATRCFMLLDFGDASTDAVKEEQPAVAAGAAAPQLRVLLATCACTSRGTATRVVQLAELPQQLLQAMRQAADGSVSASSRKRRASDAAEQQTLAAAAAAAGDGEMELGLAAAAAWCKRQAGESALRAQLQLLPTQHMEELSLTQPQRPAIRLPHMPVLAQLDAWAAKQLQVAGSSGAASSWGASNGGEQPGTPAGVDAAAQLGPPKPAATIQLEEGEAEAEAGQWRIQLSSLYFARLAQLLQRHGMALAPPADDVQHVTPTAAGLTLAYSLQKGRSVLTGISDIARLGMMQLCLIRLLGYMAANPLAAGAAAAVSATGGSNGTLLQPNGALTPAGKGAAGPVWPLPGCGSVRLAPVWAAQLWQRLQLEVPAFATVQPPAGANGEQRQAVLQAWVPWQGLPLALAHLMRAVAAAK
Length1509
PositionTail
OrganismChlorella sorokiniana (Freshwater green alga)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Chlorophyta> core chlorophytes> Trebouxiophyceae> Chlorellales> Chlorellaceae> Chlorella clade> Chlorella.
Aromaticity0.04
Grand average of hydropathy-0.071
Instability index50.07
Isoelectric point6.36
Molecular weight156393.95
Publications
PubMed=29178410

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP19615
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             8|    1022.28|     152|     152|     543|     694|       1
---------------------------------------------------------------------------
  431-  540 (66.07/15.09)	....................................................................................................................................YRVLPS.VIEEE.....L.......VQP..............GQR...LERPGEVPEVV....AAEQQQaatrridfLLR.S.K..LLTTELPPGLRVVRVRGGVATVA....ATggqytaclTLVPSPRDD..........VTLAKYRPP....GEPedaaA.AAV
  543-  694 (276.82/90.55)	EPEVTQP.........................VAGPSAAAA.........DGG.QPSTSAAAA..GP........LAG...................G........DADQRQGTDCWRWQL..L.......SFELLPA.AAGQDPP..PL.......LAP..............QQQW..LQQHVEQRMWV....AADMEQ........LVRLG.KQAWVTVPAAPKEQQEQGRASSAPAP....TT........SMAPSQLPA..........AADSKGKQPMAVDGEP....E.APL
  695-  813 (127.09/36.94)	..................................GEQQGAA.........AAQ.LP...AYAA..RP........LAAmhavlcqsagrlalfslllS........DARRLEG.GSWKG............GLKLSRA.AAGAGIR...........LA.................YW..LQ...........................LPSMG....WQELQCLRDGTPFQ......PTP....TG........ATAA....A..........TAGPQQQQQQQQQQQP....E....
  814-  933 (143.02/42.64)	PPAVDVV.........................V......RE.........DGNlAASSSPQLH..HP........LSG...................EavqlplplDSAASFGAD....RL.............LLQA.AACSAAV..Q........LAA..............VQAV..LQ....RRGHL....AAN...............G.THAELSL.AAPLSPAAGAGVSEAPLP....TS...........PSLL.....................LWSSGSV....Q.LSL
  934- 1085 (138.46/41.01)	GMQLRTG.....................rlllAAGPAVLES.........EQG.SSAQAAVAA.............AQ...................Q........QLDQLQ.....RDAL..LqplppgtSRGMLAA.RLAADAV..AR.......LS.....................LQLSVQRRMDA....AAAAAA........GFGMA.RAA...LPQRLL.QQHMGTVSLLLAPlsgnTL........TLA...LPAhqpprdlarwASRQQAQQQQQGGGN..........
 1086- 1204 (100.41/27.39)	...................................................GS.GPG.SVAES..GA..trcfmlLDF...................G........DA....STDAVK...............EEQPAvAAGAAAP..QL.....rvLLAtcactsrgtatrvvQLAE..LPQQLLQAMRQ....AADG.....................SVSASSRKR....RASDA.AE....QQ........TLAAA...A..........AA........AGDGEM....E.LGL
 1234- 1382 (104.48/28.85)	ELSLTQPqrpairlphmpvlaqldawaakqlqVAGSSGAASswgasnggeQPG.TPAGVDAAAqlGPpkpaatiqLEE...................G........EAEAEAGQ..WRIQLssL.......YFARL.A.QLLQRHG..MA.......LAP..............PADD..V.QHV......................................................TP....T...........AAGLTLA..........YSLQKGRSVLT..GIS....DiARL
 1396- 1495 (65.93/15.04)	MAANPLA.........................AGAAAAVSA.........TGG.SNGTLLQPN..GA........LT...........................................................PA.GKGAAGPvwPLpgcgsvrLAP...........vwaAQLWqrLQLEVPAFATVqppaGANGEQ..........RQAvLQAWVPWQGLP.........................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     481.17|     156|     207|      34|     200|       2
---------------------------------------------------------------------------
   34-  200 (238.07/141.45)	PGDVKAHSHHVFVkLPAPSGSSG.ATDEGWWPESV..DAEPTIKAVTTAIK...EAGAAINGAVKVT...AFDRLTSKALAPGScDVLVLGAGAAGVGLQSVPlDRLPavvlaALTGGDAAAAAGPDAQSSEDVADTvLVVC...CHVARD.ERCGHIGPPLADKLAELagTQAATGGVR
  236-  404 (243.10/119.19)	PGNANEFLTALFA.CKAPHGPAGdRVLRKYWRGCVglSKEQQLERFEHGLKdieDMGLPPAGQAAMEqpgAHQALDSLKLVPFR.DVLENVCQEAHAGLQALA.DRLP.....ALDDQQRKAELLQHLQTTQQRLQR.LHVCaqwAHKAKAvNTCREVLKASQDHSAAL..VHAADEFFR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19615 with Med14 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AHQPPRDLARWASRQQAQQQQQGGGNGSGPGS
2) DVTLAKYRPPGEPEDAAAAAVKEEPEVTQPVAGPSAAAADGGQPSTSAAAAGPLAGGDADQRQ
3) GAASSWGASNGGEQPGTPAGVDAAAQLGPPKPAATIQLEE
4) MRQAADGSVSASSRKRRASDAAEQQTLAAAA
5) QAWVTVPAAPKEQQEQGRASSAPAPTTSMAPSQLPAAADSKGKQPMAVDGEPEAPLGEQQGAA
6) QCLRDGTPFQPTPTGATAAATAGPQQQQQQQQQQQPEPPAVDVVVRED
1060
520
1271
1162
639
777
1091
582
1310
1192
701
824










Molecular Recognition Features






MoRF SequenceStartStop




NANANA