<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19605
Description |
Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MNSNMPQHQIVQSPARLGLANPTSPSLQNPNPPKPPSQQSNASSTLISLLPPLPRAQSLLVQMASLASKLFEVSPNRSLWLNAFRGSLPTFLPSQNQSVPITPLDSNPSSTKDILSQFTVLQTQLFQAVAELQEILDLQDSKLKIAQEIRSKDAALLAFSKKLKDAEQILDNLVDDYSDYRRPKRPKLEEDDAEDEESSCATTVTSKLKLSDILSYAHRISYTTFAPPDFGAGQAPLRGALPPAPQDEQMRASQLYHFANLDVGLPKTVESEEKTIETIIEPPPPQPTEYNQHAGMVPFQGILPPNFTIPSGWKPGMPVELPTDLPVPPPGWKPGDPVPLPPLDNLPIPLPPQTRTNAPQGIHKPPETIQVQHVQLDILDQDDDSSDYSSDEGSSEDDD |
Length | 399 |
Position | Middle |
Organism | Rosa chinensis (China rose) |
Kingdom | Viridiplantae |
Lineage | Eukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta>
Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae>
rosids> fabids> Rosales> Rosaceae> Rosoideae> Rosoideae incertae sedis>
Rosa.
|
Aromaticity | 0.05 |
Grand average of hydropathy | -0.550 |
Instability index | 73.01 |
Isoelectric point | 4.62 |
Molecular weight | 43729.61 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP19605
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 93.52| 18| 18| 309| 326| 1
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299- 315 (34.87/14.95) FQGI.LP..PNFTI.PSG.WKP
316- 334 (32.83/13.64) GMPVELP..TDLPVpPPG.WKP
345- 365 (25.82/ 9.14) NLPIPLPpqTRTNA.PQGiHKP
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 54.97| 15| 18| 24| 38| 2
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24- 38 (29.11/10.93) SPSLQNPNPPKPPSQ
43- 57 (25.86/ 8.83) SSTLISLLPPLPRAQ
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