<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19603

Description "Putative mediator complex, subunit Med12"
SequenceMQRYQPTGLTGAVSNNTIGGASGRDSVRAESATLPAHLPLNSRRPSQIAPYKLKCDKDPLNARLGPPDFHPQTPNCPEETLTREYVQSGYRETVEGIEEAREISLSQAQHFTNPLVFRCREAIKKRLRAINESRAQKRKAGQVYGVPLADSLLTKPGVFPEQRHCGDDLRKKWIEGLSQQHKRLRSLADHVPHGYRKRSLFEVLTRNNVPLLRATWFVKVTYLNQIRPGSSSISSGIPDKTQLSRTEHWTKDIIEYLQYLLDEFFSRNSSLPGSHNRERSQQMLYAGSVSQRSDPASSVLGGDEPSLHFKWWYVVRLLQWHHAEGLLLPTLVIEWVLRQLQEKELLEIVQLLLPIIYGVLETVVLSQTYVRNLVGTAVRFIREPSQGGSDLVDNSRRAYTVSALVEMLRYLILSVPDSFVALDCFPLPPCVVSYAVNDGSLQKMSEDVRKIKIGSAEVASVFRSKAFDAQYQSLAFDHVVSSIQKRADNLEKAASPSYPGHSIAKAVQALDRSLAQGDVLGVYRFLFEDPCEGIINESWVAEVSPCLRTSLKWIGTVNLSFVCSVFFLCEWATCDFRDFRTAPPCELKFTGRKDFSQVHIATRLLMLKIRDLQSSPQHKNDNPAKGSIQQINIPVRSSMGSSYESKNKSRSVHQRSTKSSNIFESPGPLHDVIVCWIDQHDAGKGEGLKRLQFLVIELIRSGIFYPHVYVRQLIVSGIMDINGPVTESDRRKRHYQILKLLPGVFVHDALEEAVVAEGPKLLEAMSSYSNERRLILNGFLGDQNKNLSMKSALKQKNNAIPGKDCGLPVSADQWKTVELSSSILSGKSGKRGKIDADVEELKEAISLLLQLPYSSTPPTDTGLEESQGSVKRPFGSISNKMDLGEGTPGCEECRRAKRQKVSDERSSYIQGNSPIPSDDEDTWWMRKRSKSSEPLKVDPPVKLTKQVSRSRQKIVRKTQSLAQLAAARIEGSQGASTSHVCNNKISCPHHRSGLEGEPPKPTDTTKTNHAGDIVSIGKALKRLRFAEKRTITVWLMTNIRQLVEETEKTIAKVGQFGRNFTAVDDRSSIRWKLGEDELSAALYLMDVSDDLVSAVKFLLWLLPKVITSPSSTIHSGRNILLLPRNVEGQVCEVGEAFLISSLRRYENILLATDLIPEVLSATMLRASAVVASNGRVSGSAALVYSRYLLKRYGNVASVIEWEKSFKVTCDKRLYSELESGQTVDGELGFALGVPSGVEDLDDYFRQKISGVRLSRVGLNMREIVQKNVNVDDAFHYFSGKERKLFAGSTPKAPAIEKWDDGYQIAHKIITELMDCIRQTGGAAQEGDPTLVSSAVSAIVGNVGSILAKVSDFRPGGYPSATDSLNFARRILRIHISCLCLLKEALGERQTRVFEVALATEACSALAGVFSPGKGSRNQYQLSPESHDSNTKVAAAVSALIIGAVINGITSLERLVTVFRFKEKLDIIQFVRNSRSNSNGNARTAGALKGDNSLEVYVHWFRLLVGNCRTVSDGMVVELLGEPSIIALSRMQRMLPLRLVFPPAYSIFAFVIWWPFLLNTCLAVREDFNQSYQSLATAIGDVIKHLPFRDVCLRDSQGFYDLVAADSSDAEFAAMLDLNGSDIHIKSMAFVPLRARLFLNAILDCKLPNSLFPQAEGNQVSGQGETKVHYSERETKLVHILDTLQPAKFHWQWVELRLLLNEQALIEKLETQDMSLVDAIRSSSPSPEKAAASENEKYFIEIILTRLLVRPDAATLFSDVVHLFGRSLADSMLLQVKWFLGGSDVLFGRKTIRQRLMNIAESKGLSTKTHFWKPWGWFTSESDLLTNRGDKKKFEVTSLEEGEMVEEGTESKRHGKGSSQLFDNEGQSVSQQHVTERALIELLLPCIDQSSDDSRNTFANDLIKQLSNIEQQINAVTRGTSKQAGQTPSGIEGPTSKGNNRKGIRGGSPGLARRAAAAAAADSAPPSPAALRASMSLRLQLLLRLLPIIYADREPSARNMRHGLATVILRLLGNRVVHEDADPSFTPSQSSLSKRESDSSMDATSAAFADLSSESLFDELLLVLHGLLSSCQPSWLRSTKPTKESGKGFVAFDRELAENLQNDLDRMQLPDTVRWRIQTTMPVIIPSIRCVVSCQPPPVPNMALAVLQSSTSNSGIYSGNSNPLQKNQVPLARTVSSVTGKSKPLPSQDYDMEIDPWTLLEDGAGSGPSSGNSALIGSADHGNLRASSWLKGAVRVRRKDLTYIGAVDDDS
Length2250
PositionKinase
OrganismRosa chinensis (China rose)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Rosales> Rosaceae> Rosoideae> Rosoideae incertae sedis> Rosa.
Aromaticity0.07
Grand average of hydropathy-0.283
Instability index50.59
Isoelectric point8.82
Molecular weight249180.02
Publications









Function






Annotated function


GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of development, heterochronic	GO:0040034	IEA:EnsemblPlants
regulation of radial pattern formation	GO:0090213	IEA:EnsemblPlants
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP19603
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.59|      20|     611|     272|     312|       1
---------------------------------------------------------------------------
  288-  308 (31.94/48.61)	SVSQRSDPASSVLGGDEPsLH
  651-  670 (37.65/ 7.35)	SVHQRSTKSSNIFESPGP.LH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     266.52|      91|    1266|     728|     934|       2
---------------------------------------------------------------------------
  744-  849 (125.42/242.87)	VFVHdaLEEAVVAEGPKLLEAMSSYSnerRLILNGFLGDQNKNLSMKSalkqkNNAI..PGKDCGL....PVSADQWKTVELSSSILSGKSGKRGKIdADveelKEAISLLL
  939- 1035 (141.10/53.81)	PPVK..LTKQVSRSRQKIVRKTQSLA...QLAAARIEGSQGASTSHVC.....NNKIscPHHRSGLegepPKPTDTTKTNHAGDIVSIGKALKRLRF.AE....KRTITVWL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.37|      20|    1208|     507|     526|       3
---------------------------------------------------------------------------
  507-  526 (34.62/20.66)	VQALDRSLAQGDVLGVYRFL
 1760- 1779 (36.75/22.41)	VHLFGRSLADSMLLQVKWFL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.42|      22|    1208|     716|     743|       4
---------------------------------------------------------------------------
  716-  743 (29.52/40.66)	SGimdINGPVTESDRRKrhyQILKLLPG
 1928- 1949 (41.90/30.31)	SG...IEGPTSKGNNRK...GIRGGSPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.13|      28|     422|    1636|    1691|       6
---------------------------------------------------------------------------
 1645- 1680 (35.50/82.11)	KLPNSLFpQAEGNQVSGQgetkvHYSERetKLVHIL
 1855- 1882 (48.63/19.05)	KGSSQLF.DNEGQSVSQQ.....HVTER..ALIELL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     225.17|      72|    1117|     403|     482|      10
---------------------------------------------------------------------------
  403-  482 (114.13/82.75)	ALVEMLRYLILSV..PD.....SFVALDCFPLPPCVVSYAVNDGSLQKMSEdvrkiKIGSAEVASVFRSKAF.DAQ..YQSLAFDhvvSS
 1526- 1607 (111.04/64.39)	ALSRMQRMLPLRLvfPPaysifAFVIWWPFLLNTCLAVREDFNQSYQSLAT.....AIGDVIKHLPFRDVCLrDSQgfYDLVAAD...SS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.01|      19|    1117|     171|     189|      11
---------------------------------------------------------------------------
  171-  189 (33.67/22.13)	KKWIEGLSQQHKRLRSLAD
 1296- 1314 (35.34/23.61)	EKWDDGYQIAHKIITELMD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19603 with Med12 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) INAVTRGTSKQAGQTPSGIEGPTSKGNNRKGIRGGSPGLARRAAAAAAADSAPPS
2) KVSDERSSYIQGNSPIPSDDEDTWWMRKRSKSSEPLKVDPPVKLTKQVSRSRQKIVRKTQSLAQ
3) MQRYQPTGLTGAVSNNTIGGASGRDSVRAESATLPAHLPLNSR
4) TSHVCNNKISCPHHRSGLEGEPPKPTDTTKTNHAG
5) VTSLEEGEMVEEGTESKRHGKGSSQLFDNEGQS
1912
900
1
977
1835
1966
963
43
1011
1867










Molecular Recognition Features






MoRF SequenceStartStop




1) RRAAAAA
2) YDMEIDPWTLLE
3) YIGAVDD
1952
2189
2242
1958
2200
2248