<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19578

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMASELGQQTVDLSTVVNRAAEESFLSLKELMEKSKAAAPELSDTDKKIGLLKYLVKTQQRMLRLNVLAKWCQQVPLIQYCQQLTSTLSSHDTCFTQAADSLFFMHEGLQQACAPVYDVPSAVEILLSGSYQRLPKCIEDVGLQSSLSEDEQKPALKKLDMLVRRQLLEVSIPKEISEVKVSDGTALLRVNGEFKVLITLGYRGHLSMWRILHLDLLVGERSGLIKLEVSQRYTLGDDLERRMAAAENPFKTLYSFLHEMCVKLVIDTVLRQVQALRQGRWKDAIRFEVLSDGSTSHAGTSGSAQLNQDGETETSGLRTPGLKIVYWLDFDKNSGISDSSLCPSIKIDPGPDLLIKCVHSTFVIDPLTGKEAEFFLDQSCIDVEKLLLRAICCNRYTRLLEIQKELEKNVQICRGSGDVAFQSCVEEADSDHKKKDFKSDVREYEGHEVLRVRAYGSSFFTLGINIRNGRFRLQSSRNILASSAFLSECEDALNQGTMTAAEVFISLRSKSILHLFASIGRFLGLEVYENGLPAVKLPKNILNGSTMLLMGFPDCGSSYFLLMQLDKDFKPLFKLLETQPDSSGKADSLNDQNHVIRIKKIDVNQMQMHEDDMNLSLLDWGKLQSILSSAGRSNQSSENGLLTDISLEGSMPIAGCPPSSFSSVVDEVFELEKGLSAPSFSLQNGTSSFNTSSASHFGSAPMNLHSIKAGSPASKWEGGMQMSQLNSAANGSGMAAHYNGSLYSSSNLKGTIQSSSLSSLSSATGRSVSVKKMSVSKSDQDLASLRSPQLVDYGSTSMDEDHLRFMSDTSKGATYGFRSSRLLSPPGPSGPRISGPGMRPVTGSFRVAGSNSCVTTPATHAPDSGVCDGPNHDDSNHDRKLRKRTLSEMLNLIPSLQGVEANLGSCKRRKVSEVDQAQHSSSQVLMSTDMTSKTGLYSYGDLISEANKGYAPSSIYVSALLHVVRHCSLGIKHARLTSQMGALDIPYVEEVGLRSTSSNIWFRLPFARGDSWQHLCLRLGRAGSIYWDVKINDQHFRDLWELQKGSNTTPWGSGVRIANTSDIDSHIRYDPEGVVLSYQSVEADSIKKLVADIQRLSNARMFSLGMRKLLGVRPDEKPEESVNSDSKAPGGKGSFEGADRLSEQMRRAFRIEAVGLMSLWFSFGSGVLARFVVEWESGKEGCTMHVSPDQLWPHTKFLEDFINGAEVASLLDCIRLTAGPLHALAAATRPARAGPIPGVSGMTILSSVPKQAGYIPSQGLMQTSSTTNVSQSPVPVGNSVSSAATGPLTNHGLHGAAMLAAAAGRGGPGIVPSSLLPIDVSVVLRGPYWIRIIYRKHFAVDMRCFAGDQVWLQPATPPKGGPSVGGSLPCPQFRPFIMEHVAQELNGLDTNFNGVQQTGLANLHTQNLSAGPQLSAVNGNRVNLPSSAALSRTGNQVASLNRTGNASPVSSNLAVMSSGMPLRRSPGAGVPAHVRGELNTAIIGLGDDGGYGGGWVPLVALKKVLRGILKYLGVLWLFAQLPDLLKEILGSILKDNEGALLNLDQEQPALRFFVGGYVFAVSVHRVQLLLQVLSVKRFHHQQQQQQQNPTTAQEELTPTEIGEICDYFSRRVASEPYDASRVASFITLLTLPISVLREFLKLIAWKKGLAQQVQGGDVAPAQKPRIELCLEYHAGSNIDENSDNSSVAKSNIHYDRPHNSVDFALTLVLDSAHIPHINAAGGAAWLPYCVSVKLRYSFGENPNVSFLGMEGSHGGRACWLRVDDWEKCKQKVARTVESCSGLDNSHGRLRLVADYVQRTLHVWLQGLRDGGVVSSTPGGT
Length1819
PositionTail
OrganismRosa chinensis (China rose)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Rosales> Rosaceae> Rosoideae> Rosoideae incertae sedis> Rosa.
Aromaticity0.07
Grand average of hydropathy-0.200
Instability index43.62
Isoelectric point7.41
Molecular weight198037.92
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP19578
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.32|      21|     300|     336|     364|       1
---------------------------------------------------------------------------
  337-  357 (39.75/32.52)	DSSLCPSIKIDPGPDLLIKCV
 1709- 1729 (41.56/14.74)	DSAHIPHINAAGGAAWLPYCV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     136.06|      41|     299|     615|     684|       3
---------------------------------------------------------------------------
  617-  658 (68.38/33.21)	LDWGKLQSiLSSAGRSNQSSENGLLTDISLEGSMP.IAGCPPS
 1215- 1256 (67.68/21.62)	LTAGPLHA.LAAATRPARAGPIPGVSGMTILSSVPkQAGYIPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.85|      22|      23|    1407|    1428|       5
---------------------------------------------------------------------------
 1407- 1428 (37.82/21.41)	LS.AGPQLSAVN..GNRVNLPSSAA
 1429- 1453 (28.03/13.87)	LSrTGNQVASLNrtGNASPVSSNLA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     275.45|      89|     134|     728|     822|       7
---------------------------------------------------------------------------
  729-  822 (138.92/69.26)	NGSGMAahyNGSLYSSSNLKGTIQSSSLS.......SLSSATGRSVSVKKMSVSKSDQdlASLRSPQLV...DYGSTSMDEDHLRFMSDTSKG.ATYGFRSSRLL
  861-  960 (136.53/63.90)	PDSGVC...DGPNHDDSNHDRKLRKRTLSemlnlipSLQGVEANLGSCKRRKVSEVDQ..AQHSSSQVLmstDMTSKTGLYSYGDLISEANKGyAPSSIYVSALL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     138.29|      43|     597|    1035|    1105|       9
---------------------------------------------------------------------------
  666-  710 (70.03/25.84)	EVFELEKGLSAPSFSlqNGTSSFNTSSA.SHFGSAP....MNLHSIKAGS
 1037- 1084 (68.26/61.90)	DLWELQKGSNTTPWG..SGVRIANTSDIdSHIRYDPegvvLSYQSVEADS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.10|      14|      23|    1491|    1512|      10
---------------------------------------------------------------------------
 1466- 1479 (24.88/ 6.77)	GAG.VP.....AHVRGELNT
 1491- 1510 (16.22/17.70)	GGGwVPlvalkKVLRGILKY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.26|      16|     531|     824|     839|      12
---------------------------------------------------------------------------
  824-  839 (36.30/18.56)	PP..GPS.GPRISGPGMRP
 1356- 1374 (27.96/12.43)	PPkgGPSvGGSLPCPQFRP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19578 with Med14 domain of Kingdom Viridiplantae
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