<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19562

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMWTNVFKLPGFKQLSWYQYLPHESELIKLPDKSSVKDAATQMVLSSHLQLQKEGLLSTWTNSFVGPWDPSQGMHNPDEKIKLWLFLPGRYSTVPDSAQVAVSKLRVVSSGVWISPGDSEEVATALSQALRNRIERVLSGFAYMRFGDVFSKFHPSQSEEHLRRGQPTIEFIFAATEEGIFVHALVSAKHVRALSSGDLERVLKHSSKNSGYRLPVIASPHGICGRLTGCCPSDLVKQVYFSSSKSKTSNGFIGLPNHVSQGSGCQLRGQSCYVEVTLGCPRPGSDRALQSNSHSFRNVVKHQLAESPALGRGDQKGSLDNSTVYEKTFVYPAEAVLVPALQFARSSLKRFWLQNWIGPSMPGSSFFMLCSDSIDPMEEWNETNGIRTQRGYNSSSNSNCSSISSISSSSSETDYKMATGASELEADADSLSCRQSGLSFHDRAENDMLKLGSKRPRPGMTESFAQVGTSTSASLQDTYKSDYGSVEVNNSAITGFANEQIGSHWDWDGDDSDNGTDIHALLDEFGGFGDFFENDALPFGEPPGTAESQTLMFSAPDSGDVVDNPAGAMDVSDQLLLSEGFASFESLIPPPPAPMEETLGKNQGVGNGALASGPVNCSSASSVSEFDHIIKAEALMTFAPEYGAVETPTSEVSSSIFRSPYLPKSRRVESSSSSANNYTYGATPPSPCFDVCDEKTGKPMNSKACLGKKDANNILWSKNYYIHVGSGKEQQDGRLFTSSKDTVLTRDGVAPSSFSTLNSTNAVKASQRKMIEGTFDSENFFLSMSTIPATEIECLIFQASMCRIRHTLLSSSSLSSIGRLPGEPCMMPDNVSGKYELKRKDSIPIRIAGDNDGGIIDGHLNAPVGVWRSVGAPRVSKPSSSSSMEISTSLPHTSFGDEGMLSYGQRQPLQELLDGITLIVQQATAFVDLALDSDCGDGPYGWLALQEQWRKGFSCGPSMVHAGCGGTLASCHSLDIAGVELTDPLSADVHASSVISLLQSDIKTALKSAFGMLDGPLSVTDWCKGRNQSGETTVDGFSAESTISDCRDSSSTVALSMGEPLSPSPSVGSTGLKDVAKVDETSQRRSNQENSSSESDLQISSRLRPTLLVAPLPAILVGYQDDWLKTSASSLHLWEKAPLEPYALQKPITYCVICPDIDPLTSAAADFFQQLGSVYETCKLGTHLPQSFGNQMEVDSGKLSSAGFVLLDCPQAMKIESSNASLVGSISDYFLSLSNGWDLTSYLKSLSKALKALKLGQCLSTNAKEGSSSPSMVIYVVCPFPEPIAVLQTVIESSVAIGSVVFQSDRERRSTLHSQVSKALSYSAAVDEASISNVLVLSGFSVPKLVLQIVTVDAIFKVTSPSLNELVILKETAFTVYNKARRISRGSSNDTVQSSSLSGRPHSVLTQMSSPSPGMWKDCVGPRITGHSLPREGEIDASLRTGAWDGSWPRTAAVSCDASRMGDIFLQDETRYMFEPFFILAEPGSVDRGISPLASGNYPSESSKPLSDESGGVFMPTASGDTGSGSQADISELDKTPSLHCCYGWTEDWRWLICIWTDSRGELLDSHIFPFGGISSRQDTKGLECLFVQVLQQGCQILQVCSSDTGLTKPRDFVIARIGSFYELEYQEWQKAINSVGGSEVKKWNLQLRRSVSDGMSASSNGPSLQQQEMSLIQERNLPSSPGPLYGSPHSKMSGYMKGGLGQPSARKQLMGAHTLIDSSRSLLQWVQSISFVTIAIDHSLQLVFQADIPSPGAQGGFGVGSSGYLEGFTPVKSLGSTPASYILIPSPSMRFLPPTPLQLPTCLTAESPPLAHLLHSKGSAIPLSTCFVVSKAVPTMRKDYRSNLKEEWPSTLLVSLIDHYGGNNFSQEKIMRGNAKQLGRSPPSSEAREFEIEAHAILESVAAELHALSWMTLSPAYLERRTALPFHCDMVLRLRRLLHFADKELSKHPEKAQTVA
Length1956
PositionKinase
OrganismRosa chinensis (China rose)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Rosales> Rosaceae> Rosoideae> Rosoideae incertae sedis> Rosa.
Aromaticity0.08
Grand average of hydropathy-0.247
Instability index52.82
Isoelectric point5.52
Molecular weight211404.38
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP19562
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     361.54|     121|     177|    1383|    1557|       1
---------------------------------------------------------------------------
 1383- 1526 (183.36/161.34)	SRGSSNDT..VQSSSLSGRPHS.....VLTQMSSPSPGMWKDCVGPriTGHSLPREGEIdasLRTGAW....DGSWPRtAAVSCDASRMGDIFLQdETRymfepffilaepgSVDRGISplASGNYPSE...............SSKPL..SDES..GGvFMPTASGDTGSGSQ
 1558- 1708 (178.18/73.79)	SRGELLDShiFPFGGISSRQDTkglecLFVQVLQQGCQILQVCSSD..TGLTKPRDFVI...ARIGSFyeleYQEWQK.AINSVGGSEVKKWNLQ.LRR.............SVSDGMS..ASSNGPSLqqqemsliqernlpsSPGPLygSPHSkmSG.YMKGGLGQPSARKQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     177.45|      49|     174|     241|     300|       2
---------------------------------------------------------------------------
  204-  237 (40.02/10.14)	..................HSSKNSGYRLpviaSPHGIC..GR...LTGCC..P...SDLVKQ
  241-  289 (91.68/54.01)	SSSKS..KTSNGFIGLPNHVSQGSGCQL....RGQSCY..VE...VTLGC..PRPGSDRALQ
  408-  458 (45.76/15.47)	SSSETdyKMATGASELEADADSLS.CRQ....SGLSFHdrAEndmLKLGSkrPRPG......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     415.62|     136|     175|     920|    1094|       3
---------------------------------------------------------------------------
  927- 1068 (222.32/180.26)	DLALDSD......CGDGPYGWLALQEQWRKgfsCGPSMVHAGCGGTLAScHSLD..IAGVEL...TDPLS...ADVHaSSVISLLQS.DIKTALKSAFG................MLDGPLSVTDWCKGRNQSGETTvDGFSAESTISDCRD.....SSSTVALSMGEPLSPSPSVGS
 1095- 1266 (193.29/97.02)	DLQISSRlrptllVAPLPAILVGYQDDWLK...TSASSLHLWEKAPLEP.YALQkpITYCVIcpdIDPLTsaaADFF.QQLGSVYETcKLGTHLPQSFGnqmevdsgklssagfvLLDCPQAMKIESSNASLVGSIS.DYFLSLSNGWDLTSylkslSKALKALKLGQCLSTNAKEGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.29|      29|     175|     459|     514|       4
---------------------------------------------------------------------------
  484-  513 (46.45/39.01)	SVEVNNSAITGFANEQIGSHWDwDGDDSDN
  535-  563 (50.83/11.26)	ALPFGEPPGTAESQTLMFSAPD.SGDVVDN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.01|      24|     176|     459|     482|       5
---------------------------------------------------------------------------
  459-  482 (41.48/25.54)	MT..ESFAQVGTSTSASLQDTYKSDY
  635-  660 (38.53/23.11)	MTfaPEYGAVETPTSEVSSSIFRSPY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     135.80|      45|      54|       2|      54|       6
---------------------------------------------------------------------------
    2-   54 (66.85/59.91)	WTNVFKLPgfkqlsW..YQYLPHESELIK....LPDK.SSVKDAAtQmVLSSHLQLQKEG
   59-  110 (68.96/40.43)	WTNSFVGP......WdpSQGMHNPDEKIKlwlfLPGRySTVPDSA.Q.VAVSKLRVVSSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     133.62|      39|     216|     364|     406|       9
---------------------------------------------------------------------------
  364-  406 (65.10/51.95)	SFFMLCSDSIDPMEEwneTNGiRTQ...RGYNSSSNSNCSSISSIS
  582-  623 (68.52/40.99)	SFESLIPPPPAPMEE...TLG.KNQgvgNGALASGPVNCSSASSVS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.35|      17|     136|     670|     688|      10
---------------------------------------------------------------------------
  670-  688 (29.49/23.53)	SSSSANnyTYGATPPSPCF
  809-  825 (32.86/18.52)	SSSSLS..SIGRLPGEPCM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     196.89|      59|     905|     848|     926|      12
---------------------------------------------------------------------------
  862-  926 (89.74/78.16)	PVGVWRSVGAPRVSKPssSSSMEIstsLPHTSFGDEGMLSyGQRQPLQELLDGITLIVQQATAFV
 1770- 1828 (107.15/50.88)	PVKSLGSTPASYILIP..SPSMRF...LPPTPLQLPTCLT.AESPPLAHLLHSKGSAIPLSTCFV
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19562 with Med13 domain of Kingdom Viridiplantae
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