<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19512

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMTELIHQLTQQTYYQLNQLTNSLHDRSGLERRALIVLFLNQTRIKFAKLMVAVKWALNNSYAPANGREEESNKDGTAGNFIINKSWDILRVIEAQDSLLRNAADSLYNLHSEVSERSAPIYDLTNAVDVLTTGAYKRLPLVIHKTIESPTITTPRDDEKKRVIDRLSRIIHLKLFSASIPSQFTEAYVLNGHAVCGVSREFRAHITLKGDTETEPWVISHLDIFVRSDPELTEESPNLQHPSFSKQIKEVNHLAQSRMSASSNPLHDLYEVVHAFCISLQLYILSHQCQKLSKIQPSLQLVSDGSDHSKKIVIKYWTSSSVTASNTPATSSQSGETSKSPPTLEISSSPSGLTLKHTPSITDPSNHSVPLMKPRSDRLNLGEILNHVINAYVQSRLTRAYESLRPTSGGFDFHSRSRLLPSEEDAHQLCLKIDLVKNSSLNVRIDRRTGLYSLKVEPPSFEEDFIKLLEDRINSMDVGEIKTVVRVSLNRKMVEYYESLAHSARLTTTRRLPKRSLVANANFTENALYIRLAQPHQDYFLVVEITEIFQQKLFLIRTKPNDEVTGLVNIEQVEALPDRHNGSIELKPLPIAACYRILNRMRE
Length602
PositionTail
OrganismPlanoprotostelium fungivorum
KingdomAmoebozoa
LineageEukaryota> Amoebozoa> Evosea> Variosea> Cavosteliida> Cavosteliaceae> Planoprotostelium.
Aromaticity0.06
Grand average of hydropathy-0.368
Instability index52.09
Isoelectric point8.38
Molecular weight68187.74
Publications
PubMed=29378020

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP19512
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.04|      16|      25|     137|     154|       1
---------------------------------------------------------------------------
  137-  154 (24.38/20.48)	RLPLVIHKTIESPTIttP
  165-  180 (27.66/16.37)	RLSRIIHLKLFSASI..P
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     351.16|     101|     215|     181|     286|       2
---------------------------------------------------------------------------
  181-  286 (168.37/110.25)	SQFTEAY.....VLNGHAVCGVS.R....EFRAH.ITLKGDTETEPWVI....SHLDIFVRSDPELTEESPN...LQHPSFSK.Q.IKEV.NHL....AQSRMSAssnplHDLYEVVHAFCISL.....QLY.ILSH
  305-  395 (78.26/41.59)	SDHSKKI.....VIKYWTSSSVTaS....NTPAT.SSQSGETSKSPPTLeissSPSGLTLKHTPSITDPSNHsvpLMKPRSDRlN.LGEIlNHVinayVQSR...................................
  397-  501 (104.53/59.65)	...TRAYeslrpTSGGFDFHSRS.RllpsEEDAHqLCLKID......LV....KNSSLNVRIDRRTGLYSLK...VEPPSFEE.DfIK.....L....LEDRINS.....MDVGEIKTVVRVSLnrkmvEYYeSLAH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.03|      21|      23|     527|     547|       3
---------------------------------------------------------------------------
  527-  547 (34.73/26.14)	LYIRLAQPHQDYFLVVEITEI
  552-  572 (33.31/24.75)	LFLIRTKPNDEVTGLVNIEQV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19512 with Med14 domain of Kingdom Amoebozoa
Unable to open file!