<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19511

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMELNMDANGFQPQYISFGAIINGVVQQTYQHFGLLINSSGNLDDLSKKERLRAFLLQTRVLMSKLYTILQWIKARPDHTKQGEKRGVGMGATLLSKVNQEIMSILEVQNRCFQMAADTLCNVHLHLRWVQEPSYDLNTAVDVLLNGSYLRLPTSLQGPLAIKPPSTDGDTKKYIVQKLGQLIDAKLSATEVPPVFSSIRIENGCAVLEAAHEFEVHLGIEVERDMWTVIKVDIKVSSDRAVEGAVGLNYENWKHQNNAIRTLAASRMEASTEPLLELYHVVHTFCIDLQLYVLYSQSYHLKKTKPNLNFYPEYSPNKLTIRYWTHTPSQGQQRILEISAETNELTIRHHPEIIDLTTKQSRQWKMQHPDALNLEAVLEEIILSSSQTQFHQLQDALQKENGRYNLIGRTKLVSEGYLKDMEDKLNQDITQITEIVRKIFHIKLMEFYEQAAHSARLIPTRYLPTKAVAEGLDVTEEAIHMRFSPPFHDFFLVVDINPSLSRHLYLLKTKPNTTYPAFVDVEKYQTIERTAVEDVLEPRPLPVSACYQILERACI
Length554
PositionTail
OrganismPlanoprotostelium fungivorum
KingdomAmoebozoa
LineageEukaryota> Amoebozoa> Evosea> Variosea> Cavosteliida> Cavosteliaceae> Planoprotostelium.
Aromaticity0.08
Grand average of hydropathy-0.289
Instability index39.17
Isoelectric point6.30
Molecular weight63437.00
Publications
PubMed=29378020

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP19511
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      32.91|       9|      24|     316|     327|       1
---------------------------------------------------------------------------
  316-  327 (13.43/17.52)	NKLTIRywtHTP
  342-  350 (19.48/11.00)	NELTIR...HHP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.70|      22|      24|     351|     374|       2
---------------------------------------------------------------------------
  351-  374 (33.73/32.22)	EIIDLTTKQSRQWKMQhpDALNLE
  378-  399 (36.97/26.15)	EEIILSSSQTQFHQLQ..DALQKE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.28|      17|      20|     515|     531|       3
---------------------------------------------------------------------------
  515-  531 (29.23/19.12)	PAFVDVEK.YQTIERTAV
  537-  554 (27.05/17.20)	PRPLPVSAcYQILERACI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.58|      18|      23|     184|     201|       5
---------------------------------------------------------------------------
  184-  201 (29.37/24.72)	AKLSATEVPPVFSSIRIE
  205-  222 (29.21/24.53)	AVLEAAHEFEVHLGIEVE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      33.28|      10|      24|     448|     458|       6
---------------------------------------------------------------------------
  448-  458 (13.72/12.95)	EQAAHsARLIP
  475-  484 (19.55/12.75)	EEAIH.MRFSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.31|      13|      23|     409|     421|       7
---------------------------------------------------------------------------
  409-  421 (22.13/13.62)	TKLVSEGY.LKDME
  432-  445 (17.18/ 9.25)	TEIVRKIFhIKLME
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.55|      25|     202|     282|     306|       8
---------------------------------------------------------------------------
  282-  306 (46.51/33.94)	HTFCIDLQLYVLYSQSYHLKKTKPN
  487-  511 (45.03/32.63)	HDFFLVVDINPSLSRHLYLLKTKPN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19511 with Med14 domain of Kingdom Amoebozoa
Unable to open file!