<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19511
Description |
Mediator of RNA polymerase II transcription subunit 14 |
Sequence | MELNMDANGFQPQYISFGAIINGVVQQTYQHFGLLINSSGNLDDLSKKERLRAFLLQTRVLMSKLYTILQWIKARPDHTKQGEKRGVGMGATLLSKVNQEIMSILEVQNRCFQMAADTLCNVHLHLRWVQEPSYDLNTAVDVLLNGSYLRLPTSLQGPLAIKPPSTDGDTKKYIVQKLGQLIDAKLSATEVPPVFSSIRIENGCAVLEAAHEFEVHLGIEVERDMWTVIKVDIKVSSDRAVEGAVGLNYENWKHQNNAIRTLAASRMEASTEPLLELYHVVHTFCIDLQLYVLYSQSYHLKKTKPNLNFYPEYSPNKLTIRYWTHTPSQGQQRILEISAETNELTIRHHPEIIDLTTKQSRQWKMQHPDALNLEAVLEEIILSSSQTQFHQLQDALQKENGRYNLIGRTKLVSEGYLKDMEDKLNQDITQITEIVRKIFHIKLMEFYEQAAHSARLIPTRYLPTKAVAEGLDVTEEAIHMRFSPPFHDFFLVVDINPSLSRHLYLLKTKPNTTYPAFVDVEKYQTIERTAVEDVLEPRPLPVSACYQILERACI |
Length | 554 |
Position | Tail |
Organism | Planoprotostelium fungivorum |
Kingdom | Amoebozoa |
Lineage | Eukaryota> Amoebozoa> Evosea> Variosea> Cavosteliida> Cavosteliaceae>
Planoprotostelium.
|
Aromaticity | 0.08 |
Grand average of hydropathy | -0.289 |
Instability index | 39.17 |
Isoelectric point | 6.30 |
Molecular weight | 63437.00 |
Publications | PubMed=29378020
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU365082
|
GO - Cellular Component | mediator complex GO:0016592 IEA:UniProtKB-UniRule
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:UniProtKB-UniRule
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP19511
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 32.91| 9| 24| 316| 327| 1
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316- 327 (13.43/17.52) NKLTIRywtHTP
342- 350 (19.48/11.00) NELTIR...HHP
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 70.70| 22| 24| 351| 374| 2
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351- 374 (33.73/32.22) EIIDLTTKQSRQWKMQhpDALNLE
378- 399 (36.97/26.15) EEIILSSSQTQFHQLQ..DALQKE
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 56.28| 17| 20| 515| 531| 3
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515- 531 (29.23/19.12) PAFVDVEK.YQTIERTAV
537- 554 (27.05/17.20) PRPLPVSAcYQILERACI
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 58.58| 18| 23| 184| 201| 5
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184- 201 (29.37/24.72) AKLSATEVPPVFSSIRIE
205- 222 (29.21/24.53) AVLEAAHEFEVHLGIEVE
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 33.28| 10| 24| 448| 458| 6
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448- 458 (13.72/12.95) EQAAHsARLIP
475- 484 (19.55/12.75) EEAIH.MRFSP
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 39.31| 13| 23| 409| 421| 7
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409- 421 (22.13/13.62) TKLVSEGY.LKDME
432- 445 (17.18/ 9.25) TEIVRKIFhIKLME
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 91.55| 25| 202| 282| 306| 8
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282- 306 (46.51/33.94) HTFCIDLQLYVLYSQSYHLKKTKPN
487- 511 (45.03/32.63) HDFFLVVDINPSLSRHLYLLKTKPN
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