Description | Mediator of RNA polymerase II transcription subunit 8 |
Sequence | MASLAGALAGAVAPSAQADGQSQKGSLNLSPDEVRALEMTRLRLVQLCNGLERFKADIYRSNPLPNPQNLQNSARILKQNMTHLLEIIQQHSSTFQRVVVYPSTNYPGRTQEGVIMQLLRKKLEPDVETLVEAAREAALAAGVDPKTSFNSTEDAQQRKERNKRARLEAEMQGYGSNDGDDDEDDDNSDDSEEGDPEPHGIGDVWFDSRAWCKTRLAEFVRDDYQDAYTAEERAMGIENVRTGLRQNLEDEYEDEDEDEDEDDTEGDQAMTDASSTLPGSDPSSAQPGGAGSGQQANTSAPMLGEDPERMLWFATRGDRDLPPGIELESQRVEKPGQKRRFGDR |
Length | 344 |
Position | Head |
Organism | Diaporthe helianthi |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Diaporthales> Diaporthaceae> Diaporthe. |
Aromaticity | 0.05 |
Grand average of hydropathy | -0.963 |
Instability index | 43.32 |
Isoelectric point | 4.42 |
Molecular weight | 38079.99 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364144 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP19421 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 194.15| 62| 76| 124| 190| 1 --------------------------------------------------------------------------- 124- 190 (96.33/57.73) EP....DVETLVEAAREAALAAGVdpKTSFnstEDAQQRKER.....NKRARLEAEMQG.YGSNDGDDDEDDDNSDD 197- 268 (97.82/47.58) EPhgigDVWFDSRAWCKTRLAEFV..RDDY...QDAYTAEERamgieNVRTGLRQNLEDeYEDEDEDEDEDDTEGDQ --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) EAEMQG 2) PMLGEDPERMLWFATRGDRDLPPGIELESQRVEKPGQKRRFGDR | 168 301 | 173 344 |
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Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab