<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19398

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMLTNVFKIGGLHQISWFQFLPHESDWTSLPDNSVKVEQKDAATTLVLSSHLQLQKEGFLSTWTNSFVGPWDPSQGLHNPGGIGVHDEKIKLWLFLPGHHSSVVESAQATVSRLRVVKFGLWLAPGDSEEVATALSQALRNCIERALYELSYMRFGDVFSKFRPSQSEETFRRGQHTVEFIFAATEEGIFVHAIISSKHIRALSCGDLERVAKQSSSNSSYKLPVIVSPHGIRGRLTGCCSDDLVKQLYFSSSKFKASNGFIGLPNHVSQGSGCQLGGQQCYVEVTLGCHRSGSDEQLHSNSNSNKNLPKHHVGESPALGIADQKGALDNMSILAAELDRTLIAWFSFLCALGSKRPRAGMTESFGQMGAATNFTVQDSYKSDLGSVEVSNSVITGVANEQIGSFWDWDDDDRDVGTDIRALLHEFGDFGDFFENDALPFGEPPGTAESQALMFSAPDCGDILSSPVGIMDVSDPLLSAEGFTSFDSFNPPPPAANDEIVSKNQGVINTSSSSGLVNHSLASSTTTSEFDHIIKAEALMTFAPEFGAVEAPSSELSSSIFRSPYFPKSRKVESSSSSSNNYVYGATPPSSPCFDGTDEKSGMLTNSKSCTIKQSSSGTVQSKNCYTLVENVKDQHDKRSSNNSVVTCDGMAASLSNVISVNATNSAQRKLPDSTFDSDSLFLSMKTVLATEIECIMYQASMCRIRHTLLSSSSPTSAGMGRLPSTILNQLPSDPSIMTDNLSGKFEVKKKESIPVRIAGDIDGRMLDGHLNAPVGVWRSVGAPRISKPTNSPNMEVSQSLPHNAFNEEGILSYGQRQPLQELLDGMALLVQQATSFVDLALDTECGDGPYGLLALQEQWRKGFSCGPSMAHAGCGGTLASCHSLDIAGVELIDPLSADVYASSVISLLQADIKTALKSAFDALDGPLSVTDWCRGRNQSGEAGNTGDGYSAESTLSESSSAAVSTGEPMSPSQTSGGPSGLKDGVKMDDTCQKRSNQENCSSEADLQMGSRLRPTLFVVPLPSILVGYQDDWLKTSANSLQFWEKAPFEPYALQKPITYGVVCPDIDPLTSAASDFFQQLGTVYETCKLGTHLPQSFGNQMEVDSGKCSTAGFVLFDCPQAMRIESGNASLVGSISDYFLSLSNGWDLTSYLKSLSKALKALKLGPCLSTNAKEGSSSSCMVIYVVCPFPEPTAVLQTVVESSVALGSVIFQSDRERRSILHSQVAKALSCSTAVDEASISNVSVLSGFSIPKLVLQIVTVDAIFRVTSPSLSELVTLKEIAFTVYNKARRMSRGSSNDVVQSSSLSTRSQLVLTQMSSHNPGMWKDCIGPRITGHSLPREGEIDSSLRPGAWDNSWQTRAGSLACDPNRMGDYFLHDEIRYMFEPLFILAEAGSLENGYTPFASGNIASESSKSLLDDSSGGYMQNASSAGSGDSASNSHIDGSDMDKASPSLHCCYGWTEDWRWLVCIWTDARGELLDSQIFPFGGISSRQDTKGLECLFVQVLQQGCQILQACSSDTGVARPRDFVIARIGSFYELEYQEWQKAINSVGGSEVKKWSLQLRRSVSDGIPANSNGTSLQQQEMSLIQDRNLPSSPSPLYSSPHSKTSGFMKGGLGQPAARKHIMSGHTVIDSSKGLLQWVQSITFAAISVDHSLHLVSQADSSSPGGTQGSLYTGPSGYLEGFTPVKSLGSTSASYILIPSPSMRFLPPTPLQLPTCLTAESPPLAHLLHSKGSAIPLSTGFVISKAVPSMRKDSRNNLKEEWPSALSISLIDHYGGNNFSQEKIVRGLIKQGRRSSSSEPREFEIETHLILESVAAELQALSWMTVSPAYLERRTALPFHCDMVLRLRRLLHFADKELSRHPEKSQTMG
Length1871
PositionKinase
OrganismTrema orientale (Charcoal tree) (Celtis orientalis)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Rosales> Cannabaceae> Trema.
Aromaticity0.07
Grand average of hydropathy-0.225
Instability index53.48
Isoelectric point5.46
Molecular weight201962.51
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP19398
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     198.05|      59|      72|    1594|    1665|       1
---------------------------------------------------------------------------
 1594- 1656 (98.46/73.44)	SSPSPLYSSPhsktSGFMKG.....GLGQPAARKHIMSGHTVIDSSKGLLQWVQSITFAAISVDHSLH
 1668- 1731 (99.58/51.15)	GTQGSLYTGP....SGYLEGftpvkSLGSTSASYILIPSPSMRFLPPTPLQLPTCLTAESPPLAHLLH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     199.37|      48|      75|     846|     912|       2
---------------------------------------------------------------------------
  846-  897 (78.90/42.77)	DGPyglLALQEqWRKGFSCGPSMAHAGCG....GTLASCHSLDIAGVELIDPLSAD
  923-  971 (73.28/43.85)	DGP...LSVTD.WCRGRNQSGEAGNTGDGysaeSTLSESSS...AAVSTGEPMSPS
 1419- 1452 (47.18/15.10)	.................SSGGYMQNASSA....GSGDSASNSHIDGSDM.DKASPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.45|      14|      31|      88|     102|       3
---------------------------------------------------------------------------
   88-  102 (23.21/17.06)	KIKLWLfLPGHHSSV
  117-  130 (27.24/14.80)	KFGLWL.APGDSEEV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     130.32|      30|      31|     427|     456|       4
---------------------------------------------------------------------------
  402-  428 (46.30/27.00)	GSFWDW..DD...DDRDVGTDIRALL..HEFGDF
  429-  458 (53.56/32.60)	GDFFEN..DALPFGEPPGTAESQALM..FSAPDC
  459-  490 (30.47/14.80)	GDILSSpvGIMDVSDPLLSAEGFTSFdsFNPP..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     196.65|      49|      73|     273|     321|       6
---------------------------------------------------------------------------
  202-  231 (30.53/12.20)	.............LSC...GDLERVakQSSSNSSYKLP...VIVSPH.GI.
  273-  321 (88.74/50.23)	CQLGGQQCYVEVTLGCHRSGSDEQL..HSNSNSNKNLPKHHVGESPALGIA
  349-  397 (77.38/42.81)	CALGSKRPRAGMTESFGQMGAATNF..TVQDSYKSDLGSVEVSNSVITGVA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     161.18|      49|     316|    1013|    1068|       9
---------------------------------------------------------------------------
 1013- 1068 (75.89/65.81)	PTLFVVPLP.......SILVGYQDD.WlKTSANSLQFwEKAPFEPYALQKPITYGvvcpdIDPL
 1330- 1386 (85.29/50.95)	PRITGHSLPregeidsSLRPGAWDNsW.QTRAGSLAC.DPNRMGDYFLHDEIRYM.....FEPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.02|      27|      30|     566|     592|      13
---------------------------------------------------------------------------
  559-  591 (41.61/23.98)	FrspyfpKSRKVESSSSSSNNYVYGATPPSSPC
  592-  623 (40.41/23.03)	F.dgtdeKSGMLTNSKSCTIKQSSSGTVQSKNC
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19398 with Med13 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GEAGNTGDGYSAESTLSESSSAAVSTGEPMSPSQTSGGPSGLKDGVKMDDTCQKRSNQENCSSEAD
939
1004










Molecular Recognition Features






MoRF SequenceStartStop




NANANA