<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19383

Description GPCR kinase
SequenceMAVVSPVPAVTQRVGRIRYPDISAVMASGDGEIVEEPIIEDIIYVAVGKDVKENKSVLLWALQNSGGKKICVLHVHVPAQMIPLMGTKFPASSLKDQEVRAYREIERQKMHKILDEYLVFCHRMGVQAEKLYTEMDCIEKGITELITKYKIRKLVMGAAADKYYSRKLTDLKSKKAIFVCQQAPSSCHIHFTCKGYLIHTRRSNLGVADVEVRSLVGTPIPSTNPGQPNHLRSQSVNLGQNNRATVTSPLQDPFRRVRSANIEKSRGMMTDVSSLDGTEGLSTPKTRRDADGRCDEWDVERSASPGSGYSTCSSTPMVHVALVPFVSNGGSDTGSDITALTHSKEALTHSSPPSVLDGGIDETLYDHLEQAFAEAENAKREAFHEAVRRGKAEKDAIDAIRRAKATESLYAEELKHRKEIEEALAKERGELDKMKNQRNEVWEELRAAMDQKSLLESQIAESDEMVKQLEQKILSAVELLQNYKKEQDELQVERDNALSEAEELRRKQGEGTSTHIPQFFSEFSFSEIEESTNKFDQSLKIGEGGYGSIYKGLLRHTLVAIKMLHAHSMQGPSEFQQEVDVLSKLRHPNLVTLIGACPEAWALVYEYLPNGSLDDRLCCKDNTSPLSWQTRIRIATELCSVLIFLHSSKPHSIVHGDLKPANILLDANFVSKLSDFGICRLLSHGESSSNNTTLCCRTDPKGTFAYMDPEFLSTGELTSKSDVYSFGIILLRLLTGKPALGITKEVQYALDNGNLKTLLDPLAGDWPFVQAEQLARLALRCCEMNRKSRADLVSDVWRVLEPMRASCGGSSSFRLGSGEHFQPPSYFICPIFQEVMQDPHVAADGFTYEAEALRGWLDSGHDTSPMTNHKLEHCNLVPNHALRSAIQEWLQQH
Length893
PositionTail
OrganismTrema orientale (Charcoal tree) (Celtis orientalis)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Rosales> Cannabaceae> Trema.
Aromaticity0.06
Grand average of hydropathy-0.397
Instability index47.45
Isoelectric point6.05
Molecular weight99570.98
Publications









Function






Annotated function

Functions as an E3 ubiquitin ligase.



GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-UniRule
protein kinase activity	GO:0004672	IEA:InterPro
ubiquitin-protein transferase activity	GO:0004842	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP19383
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.34|      19|      24|     461|     484|       1
---------------------------------------------------------------------------
  461-  481 (26.46/26.26)	ESDEMvkQLEQ.KILSAVELLQ
  486-  505 (26.87/11.00)	EQDEL..QVERdNALSEAEELR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.95|      26|      28|     306|     332|       2
---------------------------------------------------------------------------
  306-  332 (44.88/28.61)	GSGYS..TCSSTPMVHVAlVPFVSNGGSD
  334-  361 (42.08/22.62)	GSDITalTHSKEALTHSS.PPSVLDGGID
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      80.11|      22|      29|     128|     151|       3
---------------------------------------------------------------------------
  102-  119 (22.08/11.47)	....YREIE..RQKMHKILDEYLV
  128-  151 (30.15/25.92)	AEKLYTEMDciEKGITELITKYKI
  160-  177 (27.88/16.21)	ADKYYS......RKLTDLKSKKAI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.96|      26|      30|     192|     220|       4
---------------------------------------------------------------------------
  192-  220 (41.76/37.11)	TCKGYLIHTRRS..NLGVADvevRSLVGTPI
  223-  250 (43.20/29.82)	TNPGQPNHLRSQsvNLGQNN...RATVTSPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     284.15|      69|     162|     580|     648|       5
---------------------------------------------------------------------------
  580-  648 (119.91/83.83)	DVLSKLRHPNLVTLIGACPEAWALVY.EYLPNGSLDDRLCCKDN..............TSPLSWQTRIRIATELCSVLIFLHSS
  668-  733 (66.88/43.24)	NFVSKLSDFGICRL.........LSH.G..ESSSNNTTLCCRTDpkgtfaymdpeflsTGELTSKSDV...YSFGIILLRL...
  745-  806 (97.37/66.58)	EVQYALDNGNLKTLLDPLAGDWPFVQaEQLARLAL..R.CCEMN..............R.....KSRADLVSDVWRVLEPMRAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      73.28|      18|      18|     415|     432|       7
---------------------------------------------------------------------------
  379-  395 (22.33/12.11)	..KREAFHEAVRRGKAEKD
  415-  432 (29.02/17.95)	K.HRKEIEEALAKERGELD
  435-  450 (21.93/11.77)	KnQRNEVWEEL...RAAMD
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19383 with Med32 domain of Kingdom Viridiplantae
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