<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19381

Description Mediator of RNA polymerase II transcription subunit 4
SequenceMLQHQIVHSPARLGLTNPNSPSLPNPNPNPNPNPTPPKIPPPSQQPQQQQQQPLSNPSPATATATATSSTLLSLLPPLPRAQSLLIQMASLASRLFEVSPNRSLWLTAFRGTLPTFLSSQTQPSSSSTSLDSLPSSTKEILALFTSLQTQLFEAVAQLQEILDLQDSRSKVAREIKSKDTALLAFAHKLKEAERVLDILVDDYSDYRRPKRSKLEDNTAEDDDDDDDDDDDSHATTTVASRLNLSDILFYAHRISYTTFAPPEFGAGQAPLRGALPPAPQEEQMRASQLYNFASLDVGLPKLVESEEKAVEPMIEPPAPPPAEPNPLSNLAAIQGLLHPNITVPSGWKPGMPVKLPSELPLPPPGWKPGDPVPLPPLASLPIPRVGEQQLRSKQPEPIQVRHVQLDIIDQDDDSSDYSSDDGSSEDDD
Length428
PositionMiddle
OrganismTrema orientale (Charcoal tree) (Celtis orientalis)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Rosales> Cannabaceae> Trema.
Aromaticity0.04
Grand average of hydropathy-0.554
Instability index72.95
Isoelectric point4.63
Molecular weight46586.54
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364141

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP19381
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     132.68|      18|      18|     344|     361|       1
---------------------------------------------------------------------------
   25-   41 (34.43/11.94)	NPNPNP.NPNPTP..PKIPP
  316-  343 (28.53/ 8.62)	PPAPPPAEPNPLH..PNITV
  344-  361 (35.76/12.69)	PSGWKPGMPVKLP..SELPL
  363-  382 (33.96/11.68)	PPGWKPGDPVPLPplASLPI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     111.87|      38|      40|      58|      97|       2
---------------------------------------------------------------------------
   58-   97 (58.08/34.27)	SP.................ATATATATSSTLLSLLPplPRAQSLLIQMASLASRLFE
   99-  153 (53.78/26.01)	SPnrslwltafrgtlptflSSQTQPSSSSTSLDSLP..SSTKEILALFTSLQTQLFE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.46|      18|      36|     161|     178|       3
---------------------------------------------------------------------------
  161-  178 (29.49/18.89)	ILD.LQDSRSKVAREIKSK
  195-  213 (27.97/17.58)	VLDiLVDDYSDYRRPKRSK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19381 with Med4 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MLQHQIVHSPARLGLTNPNSPSLPNPNPNPNPNPTPPKIPPPSQQPQQQQQQPLSNPSPATATATATSSTLLS
2) PSGWKPGMPVKLPSELPLPPPGWKPGDPVPLPPLASLPIPRVGEQQLRSKQPEPIQVRHVQLDIIDQDDDSSDYSSDDGSSEDDD
1
344
73
428










Molecular Recognition Features






MoRF SequenceStartStop




1) QLRSKQPEPIQVRHVQLDIIDQ
389
410