<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19368

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAAELGQQTVEFSTLVSRAAEESFLTLKELVEKSRASDQSDTEKKINILKYLVKTQQRMLRLNVLAKWCQQVPIIQHCQQLASTLSSHDTCFTQAADSLFFMHEGLQQARAPVYDVPSAIEVLLTGNYQRLPKCIEDVGMKSTLNEDQQKPALKKLDTLVRSKLLEVSLPREISEVKISNGTALVRVNGEFKVLVTLGYRGHLSMWRILHLELLVGERGGLIKLEESRRHALGDDLERRMAAAENPFITLYSVLHELCVALVMDTVIRQVQALRQGRWRDAIRFELISDGSMGHGGSTGSSQLNQDGEAESSGLRTPGLKIIYWLDFEKNTGMPDSGSCPFIKIEPGPDLQIKCLHNTFVIDPLTGREAEFLLDQSCIDVEKLLLRAICCNRYTRLLEIQKDLGKNVQISRSVGDIVLQSSVDEADIESKMKDYKASAREHEEGQEVLRVRAYGSSFFTLGINIRTGRYLLRSSQNIIESSALSECEDALNQGSMNAAEVFISLRSKSILHLFASIGRFLGLEVYEHGFPAVKVPKNILNGSATLVMGFPDCGSSHFLLMQLDKDFKPLFKLIETQSDSPGKAHSFNDLNQVMRIKKIDVGQMQMLEDEMTLSLLEWEKAHSFLPSAGAANQTSENSLLSDLSLEGSMQIAGGRPSSFSSIIDEVFELERGSSIQNVSSPFSASPISRFGSIPVNLHAIKTGTPSPKWEGSLQTSQISNFAKVSSVTTAYAGSLHSSSHLKGSTHSNSLGHLSSVPGRSSAGKKLSASKSEQDLASLRSPQSAEFGSSTSMDEDQLRLLNDTSKEMYGRSSQLLSPPRPIGPRGSVSSVKANGPRISPSQPLTGSFRVAGSSSCATPMSHAQALDSAVYHSPCDVVSRHDKNPRKRTVSDMLNLIPSLKGVEANSGICKRRKISEVTGAQKSSPQLLMPMEMVSKSDGYSYGNLIAEANKGNAPSSIYVSALLHVVRHCSLCIKHARLTSQMEALDIPYVEEVGLRSASSSIWFRLPLARGDTWQHICLRLGRPGSMYWDVKINDQHFRDLWELQKGSNCTPWGSGVRIANTSDIDSHIRYDPEGVVLSYQSVESDSIKKLVADIQRLSNARIFALGMRRLLGVRADEKAEESSPSSDVKSPVGAKASLEVVDRLSEQMRRAFRIEAVGLMSLWFSFGSGVVARFVVEWESGKEGCTMHVSPDQLWPHTKFLEDFINGAEVASLLDCIRLTAGPLHALTAATRPARAGPIPGVPGVAAALSSLPKQAGYLASQGLLPSSSATNGSQGPSGAVGNPVAATSASPLANHSLHGAAMLAAASRGGPGIVPSSLLPIDVSVVLRGPYWIRIIYRKHFAVDMRCFAGDQVWLQPATPPKGGPSVGGSLPCPQFRPFIMEHVAQELNVLEPNFAGSQQAGGLATNQNQSSGSQLSSANGNRINLPGSASMARTGNQVAALNRLGNVPPGSSNLAVMASGVPLRRSPGTGVPAHVRGELNTAIIGLGDDGGYGGGWVPLVALKKVLRGILKYLGVLWLFAQLPDLLKEILGSILKDNEGSLLNLDQEQPALRFFVGGYVFAVSVHRVQLLLQVLSVKRFHHQQQQQQQQNSTTAQEELAQSEIGEICDYFSRRVASEPYDASRVASFITLLTLPISVLREFLKLIAWKKGLAQAQGGDVAPAQKPRIELCLENHAGLSMDESSENSSIAKSNIHYDRPHNSVDFALTVVLDPAHIPYVNAAGGAAWLPYCVSVRLRYSFGENPNVSFLGMDGSHGGRACWFRVDDWEKCKQRVARTVEIHSPGDTSQGRLRGVADNVQRTLNVCLQGLRDGSGVTASSGST
Length1824
PositionTail
OrganismTrema orientale (Charcoal tree) (Celtis orientalis)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Rosales> Cannabaceae> Trema.
Aromaticity0.06
Grand average of hydropathy-0.188
Instability index46.46
Isoelectric point8.17
Molecular weight198149.25
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP19368
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     388.51|     123|     302|     471|     599|       2
---------------------------------------------------------------------------
  471-  599 (188.55/121.91)	LRSSQNIIESSALSECEDALNQGSMNAAEVFisLRSKSILHLFASIG.RFLGLEVYEHGfPAVKvPKNILNGSATlVMGFPDCGSSHFLLMQLDKD.FKPLFKLIETQSDSPGKaHSFND.LNQVMRIKKID
  777-  902 (199.96/109.52)	LRSPQSAEFGSSTSMDEDQLRLLNDTSKEMY..GRSSQLLSPPRPIGpRGSVSSVKANG.PRIS.PSQPLTGSFR.VAGSSSCATPMSHAQALDSAvYHSPCDVVSRHDKNPRK.RTVSDmLNLIPSLKGVE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     337.49|      97|     319|    1321|    1494|       3
---------------------------------------------------------------------------
  646-  710 (80.17/18.17)	................................GSMQiAGG........RPSS.FSSIIDEVFELERGSSIQ....NVSSPFSAspISRFGSIP......VNLHAIKTGTPSPKWEG
 1234- 1319 (104.45/109.61)	PARAG..PIPGV.P....GVAAALSSL.PKQAGYLA.SQGLLPSSSATNGSQgPSGAVGNPVAATSASPLAnhslHGAAMLAA..ASRGG...PGivpSS................
 1367- 1471 (152.86/112.00)	PSVGGslPCPQFrPfimeHVAQELNVLePNFAGSQQ.AGGLATNQNQSSGSQ.LSSANGNRINLPGSASMA....RTGNQVAA..LNRLGNVPPG...SSNLAVMASGVPLRRSPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.98|      17|     261|    1474|    1499|       4
---------------------------------------------------------------------------
 1480- 1497 (28.54/18.87)	GElNTAIIGLGDDGGYGG
 1743- 1759 (32.44/ 8.98)	GE.NPNVSFLGMDGSHGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     108.06|      34|     303|    1321|    1364|       5
---------------------------------------------------------------------------
 1321- 1364 (47.14/66.30)	LPIDVsvvLRgPYWIRIIYRKHFAvdmRCFAGDqvwLQPATPPK
 1636- 1669 (60.92/43.87)	LPISV...LR.EFLKLIAWKKGLA...QAQGGD...VAPAQKPR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     112.52|      36|     704|     955|     994|       6
---------------------------------------------------------------------------
  955-  994 (51.41/53.57)	SSIYVSALlHVVR.HCSlcIKHArLTSQMEALDIPYVEEVG
 1689- 1725 (61.11/43.41)	SSIAKSNI.HYDRpHNS..VDFA.LTVVLDPAHIPYVNAAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.54|      23|     704|     439|     461|       7
---------------------------------------------------------------------------
  439-  461 (40.60/25.90)	REHEEGQEVLRVRAYG..SSFFTLG
 1144- 1168 (36.93/22.85)	RLSEQMRRAFRIEAVGlmSLWFSFG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.12|      15|      23|    1499|    1514|      13
---------------------------------------------------------------------------
 1499- 1514 (23.02/18.25)	W....VPLVaLKKVLRGILK
 1520- 1538 (22.09/12.13)	WlfaqLPDL.LKEILGSILK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.57|      16|     758|    1003|    1023|      14
---------------------------------------------------------------------------
 1003- 1023 (28.22/30.79)	WFRLplargDTWQHICLRLGR
 1763- 1778 (33.35/21.42)	WFRV.....DDWEKCKQRVAR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.85|      19|     354|     713|     738|      16
---------------------------------------------------------------------------
  715-  733 (31.85/30.08)	SQISNFAKVSSVTTAYAGS
  905-  923 (33.00/11.08)	SGICKRRKISEVTGAQKSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.93|      27|    1399|     142|     171|      17
---------------------------------------------------------------------------
  142-  171 (40.45/38.71)	STLNEDQQKPALKkldTLVRSKLLEVSLPR
 1543- 1569 (48.48/36.56)	SLLNLDQEQPALR...FFVGGYVFAVSVHR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19368 with Med14 domain of Kingdom Viridiplantae
Unable to open file!