<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19350

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMNEKLQISLDKLQLKRLEAIEENGAERFPTDVGYDEKRLSLIRRIDFAWAVERDDKKKQKKSAKESSTPWPWQSMVENLQLAQQELSVILDLINTVEANDAVTVASMTRPKPLPNEVLSDLAVSAATKLQCFRSLGKYFKQSAKALEQQVAREARFYGALIRLQQNWKVKRQRVAAPSSGNEGFTIDLFNNLLYDPASVYRPSSLSMVCVDHDPAGMLAINLPPSSCRSLQFGFFGTHPCDSTETSNIKVRSSDQHNSRESEKDAGSDDECIIKETHLLLRQVNQTIFDEQVFDLVNREAFNQSFGVNVTGIRENYLQLSIGQGNSVFISLVSSSQDDQAVDSAGNQDLENAILPLDTLDGVKLPEENSDSSTKELGIPDRTSCEIYLQQIFHENVFSRAKDKPVSTVPCISSQTAKEGSSLLGHFCMSLAHRIFSKKVLRVLENLVSGVPYLQLLSHPTWHSRTWSWTLLMKIPQSILYAGTQTPTSDLHYVKTTTKSQFRTKVVVTDDFITVEGEGAPSVVGLFKGNSQESSSMKRYECNLQDLPVIILQQVAGQIIRWLHEEALMVGIKVNRDFLSLSFELEQGETLSLTAHVDPEDSQGCISWWLIMEDGFAEEGKLHLDLSYGVSEYRKFVGHLSLDVLYSTLMDLILQSPINNTRAESSTKLLKYPSQVSYNRVLLLPYEDFWLGVVDWSREKPSESSHLGIEIQVFILDWLSKRRRIGLCKWVLLLKKSEILACFFGFRWYSNFQPICPVEHRLPVD
Length764
PositionHead
OrganismParasponia andersonii (Sponia andersonii)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Rosales> Cannabaceae> Parasponia.
Aromaticity0.09
Grand average of hydropathy-0.278
Instability index50.00
Isoelectric point5.66
Molecular weight86381.20
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP19350
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     133.51|      26|      41|     384|     409|       1
---------------------------------------------------------------------------
  285-  305 (23.71/11.31)	.....Q.......TIFDEQVFDLVNREAFNQSF
  313-  345 (28.99/15.34)	RENYLQlsigqgnSVFISLVSSSQDDQAVDSAG
  384-  409 (45.51/27.95)	CEIYLQ.......QIFHENVFSRAKDKPVSTVP
  427-  451 (35.30/20.16)	CMSLAH.......RIFSKKVL.RVLENLVSGVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.87|      24|      45|     556|     582|       4
---------------------------------------------------------------------------
  556-  582 (37.24/28.74)	GQIIRWL.HEEALMVGIKVNrdfLSLSF
  603-  627 (42.64/24.38)	GCISWWLiMEDGFAEEGKLH...LDLSY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.38|      12|      27|     713|     724|       5
---------------------------------------------------------------------------
  713-  724 (22.05/12.44)	FILDWLSKRRRI
  743-  754 (25.33/15.33)	FGFRWYSNFQPI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19350 with Med17 domain of Kingdom Viridiplantae
Unable to open file!