<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19335

Description GPCR kinase
SequenceMTVVSPVPALTQRVGLIRYPDISAVMASGDGEIAEEPIIEDIIYVAVGKDVKESKSVLLWALQNSGGKKICVLHVHMPAQMIPLMGTKFPASSLKDREVRAYREIERQKMHKILDEYLVFCHRMGVQAEKFYTEMDCIEKGITELITKYKIRKLVMGAAADKYYSRKLTDLKSKKAIFVCQQAPSSCHIHFTCKGYLIRTRRSNLGGADVELRSLVGTPIPSTNPGQPNHLRSQSVNLGQNNRATVTSPLQDPFRRVRSANIEKSRGMMTDVSSLDGTEGLSTPGTRRDAEGSCDEWDVEPRRSASPGSGYSTCSSTPVVHVALVPFVSNGGSETGSDITALTRSKEALTHSSPPSVLDGGIDETLYDHLEQAFAEAENAKREAFHEAVRRGKAEKDAIDAIRRAKATESLYAEELKHRKEIEEALAKENGELEKMKNQRNEVCEELRAAMDQKSLLESQIAESDEMVKQLEQKILSAVELLQNYKKERDELQVERDNALSEAEELRRKQGEGTSTHIPQFFSEFSFSEIEESTNKFDQSLKIGEGGYGSIYKGLLRHTLVAIKMLHAHSMQGPSEFQQEVDVLSKLRHPNLVTLIGACPEAWALVYEYLPNGSLDDRLCCKDNTSPLSWQTRIRIATELCSVLIFLHSSKPHSIVHGDLKPANILLDANFVSKLSDFGICRLLSHGESSSNNTTLCCRTDPKGTFAYMDPEFLSTGELTSKSDVYSFGIILLRLLTGRPALGIAKEVQYALDNGNLKTLLDPLAGDWPFVQAEQLARLALRCCEMNRKSRADLGSDVWRVLEPMRASCGGSSSFRLGSGEHFQPPPYFICPIFQEVMQDPHVAADGFTYEAEALRGWLDSGHDTSPMTNHKLEHCNLVPNHALRSAIQEWLQQH
Length895
PositionTail
OrganismParasponia andersonii (Sponia andersonii)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Rosales> Cannabaceae> Parasponia.
Aromaticity0.06
Grand average of hydropathy-0.399
Instability index50.28
Isoelectric point6.05
Molecular weight99613.04
Publications









Function






Annotated function

Functions as an E3 ubiquitin ligase.



ECO:0000256	ARBA:ARBA00003861

GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-UniRule
protein kinase activity	GO:0004672	IEA:InterPro
ubiquitin-protein transferase activity	GO:0004842	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP19335
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.20|      24|      27|     308|     334|       1
---------------------------------------------------------------------------
  308-  332 (40.40/40.74)	GSGYS..TCSSTPVVHVAlVPFVSNGG
  336-  361 (37.80/24.08)	GSDITalTRSKEALTHSS.PPSVLDGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     174.60|      53|     650|     126|     233|       2
---------------------------------------------------------------------------
  178-  233 (89.02/130.39)	FVC...QQAPSSCHIHFTCKGYLIRTRRSNL.GGADVelRSLVGTPIPSTNpGQPNH.LRS
  829-  886 (85.58/34.92)	FICpifQEVMQDPHVAADGFTYEAEALRGWLdSGHDT..SPMTNHKLEHCN.LVPNHaLRS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.94|      18|      19|     409|     426|       3
---------------------------------------------------------------------------
  409-  426 (29.07/23.26)	ESLYAEELK.HRKEIEEAL
  429-  447 (26.86/20.83)	ENGELEKMKnQRNEVCEEL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.06|      20|      22|     456|     477|       4
---------------------------------------------------------------------------
  456-  477 (27.92/24.65)	LLESQIAESDEMvkQLEQ.KILS
  481-  501 (29.14/18.73)	LLQNYKKERDEL..QVERdNALS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     284.90|      69|     162|     582|     650|       5
---------------------------------------------------------------------------
  582-  650 (119.99/69.39)	DVLSKLRHPNLVTLIGACPEAWALVY.EYLPNGSLDDRLCCKDN..............TSPLSWQTRIRIATELCSVLIFLHSS
  670-  735 (66.88/35.65)	NFVSKLSDFGICRL.........LSH.G..ESSSNNTTLCCRTDpkgtfaymdpeflsTGELTSKSDV...YSFGIILLRL...
  747-  808 (98.03/55.44)	EVQYALDNGNLKTLLDPLAGDWPFVQaEQLARLAL..R.CCEMN..............R.....KSRADLGSDVWRVLEPMRAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.84|      30|      30|     102|     131|       6
---------------------------------------------------------------------------
  102-  131 (53.23/34.06)	YREIE..RQKMHKILDEYLVFCHRMGVQAEKF
  132-  163 (44.61/27.49)	YTEMDciEKGITELITKYKIRKLVMGAAADKY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19335 with Med32 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) SETGSDITALTRSKEALTHSSPPSVLDGGIDE
2) SLVGTPIPSTNPGQPNHLRSQSVNLGQNNRATVTSPLQDPFRRVRSANIE
3) SRGMMTDVSSLDGTEGLSTPGTRRDAEGSCDEWDVEPRRSASPGSGYSTCS
333
214
265
364
263
315










Molecular Recognition Features






MoRF SequenceStartStop




NANANA