<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19330

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMLTNVFKIGGLHQISWFQFLPHESDWTSLPDNSVKVEQKDATTTLVLSSHLQLQKEGFLSTWTNSFVGPWDPSQGLHNPGEIGVHDEKIKLWLFLPGHHSSVVESAQAAVSRLRVVKFGIWLAPGDSEEVATALSQALRNCIERALYGLSYMRFGDVFSKFRPSQSEETFGRGQHTVEFIFAATEEGIFVHAIISSKHICALSSGDLERVAKQSSSNSSYKLPVIVSPHGIRGRLTGCCSDDLVKQLYFSSSKFKASNGFIGLPNHVSQGSGCQLGGQQCYVEVTLGCHRSGGDGQLHSNSNSNKNLPKHHVAGSPAFGIADQKGALDNISVYEKTFLYPPEAILAAELDRTLIAWFSFLCALGSKRPRAGMTESFGQMGAAANFTMQDSYKSNLGSVEVSNSVITGVANEQIGSYWDWDDDDGDVGTDIRALLHEFGDFGDFFENDALPFGEPPGTAESQALMFSAPDCGDILSSPVGIMDVSDPLLSTEGFTSFDSFNPPPPAANDEIVSKNQGVINTSSSSGLVHHSLASSTTTSEFDHLIKAEALMTFAPEFGAVEVPASELSSSIFRSPYFPKSRKVESSSSSSNNYVYGATPPSSPCFDGTDEKTGMLTNSKSCTIKQSSSGTVQSKNCYTLVESVKDQHDKRSSNNSVVTCDGMAASLSNVSSVNATNSALRKLPDSTFDSDSLLLSMKTVLATEIECIMFQASMCRIRHTLLSSSSPISAGMGRLPSTILNQLPSDPSIMTDNLSGKFEVKKKESIPVRIAGDIDGRMLDGHLNAPVGVWRSVGAPRISKPTNSPNMEVSQSLPHNAFNEEGILSYGQRQPLQELLDGMALLVQQATSFVDLALDTECGDGPYGLLALQEQWRKGFSCGPSMVHAGCGGTLASCHSLDIAGVELIDPLSADVYASSVISLLQADIKTALKSAFDALDGPLSVTDWCKGRNQSGEAGNTGDGYSAESTLSESSSAAVSTGEPMSPSQTSGGSSGLKDGVKMDETCQKRSNQENCSSEADLQMGSRLRPTLFVVPLPSILVGYQDDWLKTSANSLQFWEKAPFEPYALQKPITYSVVCPDIDPLTSAASDFFQQLGTVYETCKLGTHLPQSFGNQMEVDSGKCSTAGFVFLDCPQAMRIESGNASLVGSISDYFLSLSNGWDLTSYLKSLSKALKALKLGPCLSTNAKEGSSTSCMVIYVVCPFPEPTAVLQTVVESSVALGSVIFQSDRERRSILHSQVAKALSCSTAVDEASISNVLVLSGFSIPKLILQIVTVDAIFRVTSPSLSELVTLKEIAFTVYNKARRMSRGSSNDGVQSSSLSTRSQSVLTQMSPHNPGMWKDCIGPRIAGHSLPREGEIDSSLRPGAWDNSWQTRGGSLACDPNRMGDYFLYNEIRYMFEPLFILAEAGSLENGYTPFASGNIASESLKSLLDDSSGGYMQSASSAGSGDSVSNSHIDGSDMDKASPSLHCCYGWTEDWRWLVCIWTDARGELLDSQIFPFGGISSRQDTKGLECLFVQVLQQGCQILQACSSDTGVARPRDFVITRIGSFYELEYQEWQKAINSVGGSEVKKWSLQLRRSVSDGIPANSNGTSLQQQEMSLIQDRNLPSSPSPLYGSLHSKTSGFMKGGLGQPAARKHIMSGHTVIDSSKGLLQWVQSITFAAISIDHSLHLVSQADSSSPGGTQGSLYTGPSGYLEGFTPVKSLGSTSASYILIPSPSMRFLPPTPLQLPTCLTAESPPLAHLLHSKGSAIPLSTGFVISKAVPSMRKDSRNNLKEEWPSALSVSLIDHYGGNNFSQEKIVRGLIKQGRKSSSSEPREFEIESHLILESVAAELQALSWMTVSPAYLERRTALPFHCDMVLRLRRLLHFADKELSRHLDKSQTVG
Length1883
PositionKinase
OrganismParasponia andersonii (Sponia andersonii)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Rosales> Cannabaceae> Parasponia.
Aromaticity0.08
Grand average of hydropathy-0.196
Instability index52.36
Isoelectric point5.46
Molecular weight202961.89
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP19330
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     615.54|     200|     341|      41|     381|       1
---------------------------------------------------------------------------
   71-  325 (302.80/324.33)	DPSQGLHNPGEIGVHDEKIklwlflpGHHSSVVESAQAAVSrlrvvkfgiwlapgdseevatalsqalrncieralyglsymrFG....DVFSKFRPSQSEETFGRGQHTVEfifAATEEGIFVHAIISS......KHIC...ALSSGDLERVAKQSSSnSSYKLPVIVSPHGIRGRLTGCCSDDLVKQLYFSS.....SKFKASNGFIGLPNHVSQGSGCQLGGQQ..CYVEVTLgcHRSGGDGQLHSNSNSNKNLPKHHVAGSPAFGIADQKG
  491-  660 (224.21/97.47)	...................................................................................EGftsfDSFNPPPPAANDEIVSKNQGVIN...TSSSSGLVHHSLASStttsefDHLIkaeALMTFAPEFGAVEVPA.SELSSSIFRSPYFPKSRKVESSSSSSNNYVYGAT.....P..PSSPCFDG....TDEKTGMLTNSKS..CTIK.....QSSSGTVQSKNCYTLVESVKDQHDKRSSNNSVVTCDG
  942- 1017 (88.53/21.38)	DWCKGRNQSGEAGNTGDGY.......SAESTLSESSSAAVS.........................................................................................................................................................tgepmSPSQTSGGSSGLKDGVKMDETCQKRSNQenCSSEADL.......................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.50|      17|     125|    1603|    1620|       2
---------------------------------------------------------------------------
  719-  735 (27.23/ 7.82)	LLSSSSPISAGMGRLPS
 1604- 1620 (31.27/14.79)	LPSSPSPLYGSLHSKTS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     176.02|      55|     345|    1397|    1460|       3
---------------------------------------------------------------------------
 1400- 1460 (81.40/44.71)	ILAEAGSlengYTPFASGNIASESLKSLLDDSSGGYMQSASSAGSGDSVsnSHIDGSDMDK
 1741- 1795 (94.62/35.52)	LLHSKGS....AIPLSTGFVISKAVPSMRKDSRNNLKEEWPSALSVSLI..DHYGGNNFSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     117.75|      35|     341|     424|     475|       4
---------------------------------------------------------------------------
  434-  470 (60.94/64.15)	LHEFGDfgDFFENDALPFGEPPGTA.ESQALMFSAPDC
  678-  713 (56.80/23.48)	LRKLPD..STFDSDSLLLSMKTVLAtEIECIMFQASMC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     139.17|      41|     123|    1038|    1079|       5
---------------------------------------------------------------------------
 1038- 1079 (73.98/49.26)	GYQ.DDWLKTSANSLQFWEKAPF......EPYALQKPITYsVVCPDIDP
 1156- 1203 (65.18/38.67)	GWDlTSYLKSLSKALKALKLGPClstnakEGSSTSCMVIY.VVCPFPEP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.30|      24|     132|    1353|    1377|       8
---------------------------------------------------------------------------
 1353- 1377 (43.50/29.76)	GE.IDSSLRPGAWDNSWQTRGGsLAC
 1487- 1511 (40.80/23.04)	GElLDSQIFPFGGISSRQDTKG.LEC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.44|      24|     345|    1320|    1348|       9
---------------------------------------------------------------------------
  773-  796 (42.71/18.01)	DGRMLDGHLNAPVGVWRSVGAPRI
 1321- 1344 (46.73/37.38)	SQSVLTQMSPHNPGMWKDCIGPRI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19330 with Med13 domain of Kingdom Viridiplantae
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