<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19311

Description Mitogen-activated protein kinase kinase kinase
SequenceMDRREVVEEDDKFSLPTPSGRLTVGIAINGHRRSKNIVLWALDKFVPEGNISVKLIHVHPRIVAVPTAMGNLLPLSQVREDVAAVYRKEMEWQKNELLLPYRKICLQRKVEVDIVMIESDDVPSAIASQVAKLAISKLVIGAPSRGMFTRKPKGLSTKISARTPNFCTVYAVSKGKLSSIRPPNLETVRSVSDDNCDASSIITNSSYASSSQTDIGSATSSSNYRSSSLTMQRFQALTTMNQTLIRTKKDSFDSYSSRYQFSNLEEGKDDMGSCSITSDAEHALSYISSSASMENDNHSCTSDQASTSDVVTDCSSSESQVNINFEIEKLRIELRHVKGMYAMAQSETNDASQKKSIRPGLLRKINKLISFDQLKYLNKNLSDNAKKLEETIVGEEKAKELARKEKEKHEAAKREVQYVRQCAEREASLKKDAEMKATHDSKEREKLETALVGPVQQYQKFTWEEIELATCSFSEDLKIGMGGYGTVYKCSFHQTTAAVKVLCSNESHKSRQFQQELDILSKIRHPHLLLLIGVCVDHGCLIYEYMENGSLEDRLMQKNGTPPILWFERFRIAWEVASALAFLHKSKPKPIIHRDLKPANILLDHNLVSKIGDVGLAALFQSDRSSMSTMYRDTEPVGTLCYIDPEYQRTGLISPKSDVYAFGMVMLQLLTAKPAMALAHVVETAVSEGHLEDILDRKAGNWPIEETKELAELGLCCVELLRKDRPDLQAQVLPALHRLKEVADKSRDSASKVHLPPPPNHFICPILKNVMNDPCVAADGYTYDRKAIETWLESKGTSPMTNLPLSNKNLIPNYTLLSAIMEWKSHNHDFSLF
Length833
PositionTail
OrganismParasponia andersonii (Sponia andersonii)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Rosales> Cannabaceae> Parasponia.
Aromaticity0.06
Grand average of hydropathy-0.394
Instability index40.49
Isoelectric point7.30
Molecular weight93359.63
Publications









Function






Annotated function

Functions as an E3 ubiquitin ligase.



GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-UniRule
protein serine/threonine kinase activity	GO:0004674	IEA:UniProtKB-KW
ubiquitin-protein transferase activity	GO:0004842	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP19311
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      83.50|      24|      78|     184|     211|       1
---------------------------------------------------------------------------
  184-  210 (36.93/29.44)	NLETVRsvsDD..NCDASSIITNS.SYASS
  213-  227 (16.49/11.30)	..............TDIGSATSSS.NYRSS
  263-  289 (30.08/14.74)	NLEEGK...DDmgSCSITSDAEHAlSYISS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     135.31|      39|     137|     548|     588|       2
---------------------------------------------------------------------------
  548-  588 (65.11/52.97)	NGSLEDRLMQKNGTPPIlwFERFRIAWEVASALAFLHKSKP
  688-  726 (70.21/48.96)	EGHLEDILDRKAGNWPI..EETKELAELGLCCVELLRKDRP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.39|      14|      16|     413|     426|       5
---------------------------------------------------------------------------
  413-  426 (24.61/17.43)	KR..EVQYVRQCAERE
  430-  445 (18.78/11.57)	KKdaEMKATHDSKERE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.88|      26|      35|     313|     341|       8
---------------------------------------------------------------------------
  313-  341 (35.46/33.81)	DCSSSES.QVNINFEIEKLrIELRHVKgmY
  350-  376 (39.42/24.54)	DASQKKSiRPGLLRKINKL.ISFDQLK..Y
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19311 with Med32 domain of Kingdom Viridiplantae
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