<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19311

Description Mitogen-activated protein kinase kinase kinase
SequenceMDRREVVEEDDKFSLPTPSGRLTVGIAINGHRRSKNIVLWALDKFVPEGNISVKLIHVHPRIVAVPTAMGNLLPLSQVREDVAAVYRKEMEWQKNELLLPYRKICLQRKVEVDIVMIESDDVPSAIASQVAKLAISKLVIGAPSRGMFTRKPKGLSTKISARTPNFCTVYAVSKGKLSSIRPPNLETVRSVSDDNCDASSIITNSSYASSSQTDIGSATSSSNYRSSSLTMQRFQALTTMNQTLIRTKKDSFDSYSSRYQFSNLEEGKDDMGSCSITSDAEHALSYISSSASMENDNHSCTSDQASTSDVVTDCSSSESQVNINFEIEKLRIELRHVKGMYAMAQSETNDASQKKSIRPGLLRKINKLISFDQLKYLNKNLSDNAKKLEETIVGEEKAKELARKEKEKHEAAKREVQYVRQCAEREASLKKDAEMKATHDSKEREKLETALVGPVQQYQKFTWEEIELATCSFSEDLKIGMGGYGTVYKCSFHQTTAAVKVLCSNESHKSRQFQQELDILSKIRHPHLLLLIGVCVDHGCLIYEYMENGSLEDRLMQKNGTPPILWFERFRIAWEVASALAFLHKSKPKPIIHRDLKPANILLDHNLVSKIGDVGLAALFQSDRSSMSTMYRDTEPVGTLCYIDPEYQRTGLISPKSDVYAFGMVMLQLLTAKPAMALAHVVETAVSEGHLEDILDRKAGNWPIEETKELAELGLCCVELLRKDRPDLQAQVLPALHRLKEVADKSRDSASKVHLPPPPNHFICPILKNVMNDPCVAADGYTYDRKAIETWLESKGTSPMTNLPLSNKNLIPNYTLLSAIMEWKSHNHDFSLF
Length833
PositionTail
OrganismParasponia andersonii (Sponia andersonii)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Rosales> Cannabaceae> Parasponia.
Aromaticity0.06
Grand average of hydropathy-0.394
Instability index40.49
Isoelectric point7.30
Molecular weight93359.63
Publications









Function






Annotated function

Functions as an E3 ubiquitin ligase.



ECO:0000256	ARBA:ARBA00003861

GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-UniRule
protein serine/threonine kinase activity	GO:0004674	IEA:UniProtKB-KW
ubiquitin-protein transferase activity	GO:0004842	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP19311
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      83.50|      24|      78|     184|     211|       1
---------------------------------------------------------------------------
  184-  210 (36.93/29.44)	NLETVRsvsDD..NCDASSIITNS.SYASS
  213-  227 (16.49/11.30)	..............TDIGSATSSS.NYRSS
  263-  289 (30.08/14.74)	NLEEGK...DDmgSCSITSDAEHAlSYISS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     135.31|      39|     137|     548|     588|       2
---------------------------------------------------------------------------
  548-  588 (65.11/52.97)	NGSLEDRLMQKNGTPPIlwFERFRIAWEVASALAFLHKSKP
  688-  726 (70.21/48.96)	EGHLEDILDRKAGNWPI..EETKELAELGLCCVELLRKDRP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.39|      14|      16|     413|     426|       5
---------------------------------------------------------------------------
  413-  426 (24.61/17.43)	KR..EVQYVRQCAERE
  430-  445 (18.78/11.57)	KKdaEMKATHDSKERE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.88|      26|      35|     313|     341|       8
---------------------------------------------------------------------------
  313-  341 (35.46/33.81)	DCSSSES.QVNINFEIEKLrIELRHVKgmY
  350-  376 (39.42/24.54)	DASQKKSiRPGLLRKINKL.ISFDQLK..Y
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19311 with Med32 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




NANANA









Molecular Recognition Features






MoRF SequenceStartStop




NANANA