<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19305

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAAELGQQTVEFSTLVSRAADESFLLLKELVEKSRASDQSDTEKKINILKYLVKTQQRMLRLNVLAKWCQQVPIIQHCQQLASTLSSHDTCFTQSADSLFFMHEGLQQARAPVYDVPSAIEVLLTGNYQRLPKCVEDVGMQSTLNEDQQKPALKKLDSLVRSKLLEVSLPREISKVKISNGTALVRVNGEFKVLVTLGYRGHLSMWRILHLELLVGERGGLIKLEESRRHALGDDLERRMAAAENPFITLYSVLHELCVALVMDTVIRQVQALRQGRWRDAIRFELISDGSMGHGGSTGSSQLNQDGEAESSGLRTPGLKIMYWLDFEKNSGMPDSGSCPFIKIEPGPDLQIKCLHSTFAIDPLTGREAEFLLDQSCIDVEKLLLRAICCNRYTRLLEIQKDLGKMVQISRSVGDIVLHSFVDEADIESKKKDYKANAREHEEGQEVLRVRAYGSSFFTLGINIRTGRYLLRSSQNIIESSALSECEDALNQGSMNAAEVFISLRSKSILHLFASIGRFLGLEVYEHGFPAVKVPKNILNGSATLVMGFPDCGSSHFLLMQLDKDFKPLFKLIETQSDSPGKAHSFNELNQVMRIKKIDIGQMQMLEDEMTLSLLEWEKAHSFLPSAGAANQTSENSLLSDISLEGSMQIAGGPPSSFSSIVDEVFELERGSSIQNVSSPFSASPISRFGSIPVNLHAIKTGTPSPKWEGSLQTSQISNFAKVSSVTTTYAGSLHSSSHLKGPTHSNSLGHLSSVPGRSSAGKKLSASKSEQDLASLRSPQSAEFGSSTSMDEDQLRLLNDTSKEMYGRSSQFLSPPRPIGPRGSVSSLKALGHRISPSQPLTGSFKVAGSSSCATPVSHAQALDSAVYHSPCDVVSRHDKNPRKRTVSDMLNLIPSLKGVEANSGICKKRKISEVAGAQKSSPQLLMPMEMVSKSDGYSYGNLIAEANKGNAPSSIYVSALLHVVRHCSLCIKHARLTSQMEALDIPYVEEVGLRSASSSIWFRLPFARGDTWQHICLRLGRPGSMYWDVKINDQHFRDLWELQKGSNCTPWGSGVRIANTSDIDSHIRYDPEGVVLSYQSVESDSIKKLVADIQRLSNARMFALGMRRLLGVRADEKAEESSPSSDVKSPVGAKTSLEGVDRLSEQMRRAFRIEAVGLMSLWFSFGSGVVARFVVEWESGKEGCTMHVSPDQLWPHTKFLEDFINGAEVASLLDCIRLTAGPLHALTAATRPARAGPIPGVPGVAAALSSLPKQAGYLASQGLLPSSSATNVSQGPSGAVGNPVATTAASPLANHSLHGAAMLAAASRGGPGIVPSSLLPIDVSVVLRGPYWIRIIYRKHFAVDMRCFAGDQVWLQPATPPKEGPSVGGSLPCPQFRPFIMEHVAQELNVLEPNFAGSQQAGGLATNQNQSSGSQLSSANGNRINLPGSASMARTGNQVAALNRLGNVPPGSSNLAVMASGVPLRRSPGTGVPAHVRGELNTAIIGLGDDGGYGGGWVPLVALKKVLRGILKYLGVLWLFAQLPDLLKEILGSILKDNEGSLLNLDQEQPALRFFVGGYVFAVSVHRVQLLLQVLSVKRFHHQQQQQQQQNSTTAQEELTQSEIGEICDYFSRRVASEPYDASRVASFITLLTLPISVLREFLKLIAWKKGLAQAQGGDVAPAQKPRIELCLENHAGLSMDESSENSSIAKSNIRYDRPHNSVDFALTVVLDPAHIPHVNAAGGAAWLPYCVSVRLRYSFGENPNVSFLGMDGSHGGRACWFRVDDWEKCKQRVARTVEIHSPGDTSLGRLRGVADNVQRTLNVCLQGLRDGSGVTASSGST
Length1824
PositionTail
OrganismParasponia andersonii (Sponia andersonii)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Rosales> Cannabaceae> Parasponia.
Aromaticity0.06
Grand average of hydropathy-0.186
Instability index45.24
Isoelectric point8.25
Molecular weight198333.63
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP19305
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.47|      26|      29|     684|     710|       1
---------------------------------------------------------------------------
  654-  679 (41.67/21.25)	PPSSFSSIVDEVFELERGSSIQNVSS
  685-  710 (46.80/30.17)	PISRFGSIPVNLHAIKTGTPSPKWEG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     324.01|     107|     303|     471|     599|       2
---------------------------------------------------------------------------
  471-  599 (155.69/116.15)	LRSSQNIIESSALSECEDALNQGSMNAAEVFisLRSKSilhlFASIGRFLG...levyehgfpavkvPKNILNGSATlVMGFPDCGS..SHflLMQLDKD.FKPLFKLIETQSDSPGKAHSFNELNQVMRIKKID
  777-  902 (168.32/85.14)	LRSPQSAEFGSSTSMDEDQLRLLNDTSKEMY..GRSSQ....FLSPPRPIGprgsvsslkalghrisPSQPLTGSFK.VAGSSSCATpvSH..AQALDSAvYHSPCDVVSRHDKNPRKRTVSDMLNLIPSLKGVE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     116.34|      37|     300|    1320|    1364|       3
---------------------------------------------------------------------------
 1320- 1364 (51.66/48.23)	LLPIDVSvVLRgPYWIRIIYRKHFAvdmRCFAGDqvwLQPATPPK
 1633- 1669 (64.69/33.95)	LLTLPIS.VLR.EFLKLIAWKKGLA...QAQGGD...VAPAQKPR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     199.33|      65|     150|    1241|    1313|       6
---------------------------------------------------------------------------
 1246- 1313 (106.37/63.50)	VAAALSSL......PKQAGYLA.....SQGLLPSSSATNVSQGPSGA....VGNPVAttAASPLANHSlHGAAMLAAASRGGP
 1386- 1465 (92.97/46.18)	VAQELNVLepnfagSQQAGGLAtnqnqSSGSQLSSANGNRINLPGSAsmarTGNQVA..ALNRLGNVP.PGSSNLAVMASGVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     181.13|      60|     703|     955|    1035|       7
---------------------------------------------------------------------------
  955- 1023 (89.39/95.21)	SSIYVSALLHVVRHCSlcIKHArLTSQMEALDIPYVEEVG............LR..................SASSSiWFRLpfargDTWQHICLRLGR
 1689- 1778 (91.74/47.83)	SSIAKSNIRYDRPHNS..VDFA.LTVVLDPAHIPHVNAAGgaawlpycvsvrLRysfgenpnvsflgmdgshGGRAC.WFRV.....DDWEKCKQRVAR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.41|      19|      23|    1495|    1514|      12
---------------------------------------------------------------------------
 1495- 1514 (31.93/23.90)	Y.GGGWV....PLVaLKKVLRGILK
 1515- 1538 (25.47/13.55)	YlGVLWLfaqlPDL.LKEILGSILK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19305 with Med14 domain of Kingdom Viridiplantae
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