<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19303

Description Mitogen-activated protein kinase kinase kinase
SequenceMGSVAVAAEEERVFDVEETIFVAVGNRVDQSERALLWAVHRFSGKKICLLHVHKPSLVSSMTQGNTPAKRLKQRKKLRELLDNYLLILSRGGVKAYEVWIETDNVEKGIVELIAQHDVRCLVMGAAADKYYNERLADLKSKKAVFVCQQAARSCHIWFTCKGHLIYTRGDSRDRSEREVPPLLIMNSPTKINQSGEIESDSPHRLSNLDLEEDANKMDEISRWLFDHCSVDSILSSRVVNTSKFTPLHTDEEQKAQVQAVEESYFSLEQAIEDTKESKWKEFEEAVKRWKDEEDIVEAKCKANLLYGKAFQSLCVKEISQRKEIEEMLARVKQETEMMKDECDEFIKELQMVQKENLVLESQVAKSQDEIKELEEKIISAVQLLISFREKRDKLRVEHGSAVREVEWLKRLMKGETSSFCRSKLPIFSFLEINEATNEFDPSWKIAEGRYGTVYKGNIRQMHVAIKMLPSYGSKSQLDFQREVEIISRVRHPNVVTLIGMCPESRSIVYEYLKNGSLEDRLSCKENTIPWQIRTCIATEICSALIFLHTNKPSIVHGNVKPSNILLDANYVSKLGDLGVLFLIQQNKESKKSDETSFYTDPEYLETGELKPESDIYSFGVLLLRLLTARPPDVLVKDVQCALEDNNINAVLDSSAGDWPLVEAKQLAQLALRCCQRNRLDRPDLASVGWGVLEPMRTSCIASASYLVSKKCQRIPSHFVCPILQEIMEEPQIAADGFTYEAEAIRGWLHSGHDTSPMTNLKLEHLNLVPNYALQNAIQEWQLQE
Length784
PositionTail
OrganismTrema orientale (Charcoal tree) (Celtis orientalis)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Rosales> Cannabaceae> Trema.
Aromaticity0.07
Grand average of hydropathy-0.384
Instability index47.20
Isoelectric point5.65
Molecular weight89539.40
Publications









Function






Annotated function

Functions as an E3 ubiquitin ligase.



ECO:0000256	ARBA:ARBA00003861

GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:InterPro
protein kinase activity	GO:0004672	IEA:InterPro
ubiquitin-protein transferase activity	GO:0004842	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP19303
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     149.17|      48|     156|     281|     333|       1
---------------------------------------------------------------------------
  220-  269 (71.55/43.36)	ISRWLFDHCSVDSILSSRVVNTSKFTPLHTDEeqKAQVQAVEESYFSLEQ
  286-  333 (77.62/59.75)	VKRWKDEEDIVEAKCKANLLYGKAFQSLCVKE..ISQRKEIEEMLARVKQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      99.67|      29|     156|     519|     551|       4
---------------------------------------------------------------------------
   26-   54 (51.22/38.54)	NRVDQSERALLWAVHRFSGKKIC....LLHVHK
  519-  551 (48.45/46.82)	DRLSCKENTIPWQIRTCIATEICsaliFLHTNK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     173.49|      58|     496|      55|     118|       6
---------------------------------------------------------------------------
   55-  118 (88.48/68.91)	PSLVssmtQGNT.PAKRLKQRKKLRELLDNYLLIL...SRGGVKAYEVWIETDN..VEKGivELIAQHDV
  552-  615 (85.01/52.11)	PSIV....HGNVkPSNILLDANYVSKLGDLGVLFLiqqNKESKKSDETSFYTDPeyLETG..ELKPESDI
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19303 with Med32 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




NANANA









Molecular Recognition Features






MoRF SequenceStartStop




NANANA