<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19301

Description "Mediator complex, subunit Med"
SequenceMQRYHATGCTSAVNNSSIGGASGRDTARADSASLPANYPLNSRRPSLLSPYKLKCDKEPLNSRLGPPDFQPQTPNCPEETLTKEYVQSGYRETVEGLEEAREIALTQVQTFSKPVVIKCKESIRKCLRAINESRAQKRKAGQVYGVPLADSLLTKPGVFPEQRPCSEDFRKKWIEGLSQQHKRLRSLADHVPHGYRKRYLFDVLIRNNVPLLRATWFIKVTYLNQIRPSSGSVSGASDKAQLSRSELWTRDVIDYLQTLLDEFFSKNNSHSTSHNRDRSPQMLYAGSVHQRGDLVSAASDIEDSSLHFRWWYMVRLLQWHHAEGLILPSSVIDWVLRQLQDKELLEILQLLLPIIYGVLETVVLSQTYVRSLVGIAVQFIREPSPGGSDLVDNSRKAYTTSALVEMLRYLIVAVPDTFVALDCFPLPSCVVSHVVTDGSLSKSSSEDVRKIKIGSSEVSSLFRSKGLDAQYQSLAFNYVVSSIQKRADNLAKAARPGYPGHSVAKVAEALDRSRVQGDVRGAYKLLFEDLCEGVVSEHWISEVSACLRSLLKWIGTVSLSFVCSVFLLCEWATCDFRVFRTSPPVELKFTGRKDFSEVYVAIRLLKLKIGGLQNVPRTKSDNPFGVNILKKCSSQQNSFSVNTTMRGLHEFKSNSKFLDQSMKVSSIFESPGPLHDIIVCWIDQHEACKGEGFQRLQLLIVELIRAGIFYPQAYVRQLMVSGIMEMNGSVIEAERRKRHYRILKHLPGLFVRDALEEAGFAEGPELLEAMQVYSNERRLVLSGLLCNLSKQVNKTRISARKQKFYTVSGKDGASSASVDQWKPIQTSNVISGRNVKNDVDIEELKEAISVLLQLPSTSLKSTDAGLDEMQVGMKRSSVSLFNKVDMGEGTPGCEECKRVKRQKLGEERSSCLQGHSPTLSDEEDTWWVKKGSKSSDSLKVDLPLKSNKQVSRNRQKVPRKTQSLAQLAASRIEGSLGASTSHVCDNKVSCPHHRTGMEGEIPKSAEGVKTNNCTDVVSIGKALKQLRFVEKRTVSVWLVNVIRQVVEESEKTIAKVGQPGRPFTSVDDRNGVRWKLGEDELSTIMYLMDVSNDLVLAVKFVLWLLPKVLGSPNSTIHGGRSSLLLPRNVESQVCEVGEAFLISSIRRYENILIAQDLIPEALSAAMHRAATVLASNGRVSGSSVLVYARYLLRRYGNVASVVEWEKTFKATSDKRLVSELESGWSTDGELNFPLGVPAGVEDLDDFFRQKMSGGRLSRVGANMRDIVQRNLNAEDVLQHFFGKERKVFAAGTPKGPAAEKLDDGYQVAQRIISDLMDCIRQTGGAAQEGDPSLVSSAVSAIVGNVGPTIANLPDFRLGSGYPNGPSATDSLNVARRILRIHISCLCLLKEALGERQNRVFEVALATEASLALAVVFNPGKASRNQFQSSPESHDSNSSMSNENLNNSTKVVLSRTTKFAAAVSALIIGAVVHGVTNLERMVTVLRLKDGLDIVQFIRSTRSSSNGSVRSMGAFKMDNFMEVYVHWFRLLVGNCRTVSDGLTVELLGEPTIVALSRMQSMLPVVLVFPPAYSIFAFVIWRPFILSSSLSVREDINQLYQSLTLAINDAIKHLPFREACLRDGQGFYDLVAADGSDAEFAAMLELGGSDLHLKSKAFVPLRARLFLNAIIDCKMPEDGNRVSGHGESKTQLAETETKLLDKIVHVLDTLQPAKFHWQWIELRLLLNEQTLVEKLQTHDISLTDAIRSSSPSPGKAAASENENNFIQIILTRLLVRPDAASLFADVVHRFGRSLEDSMLLQAKWFLGGSDVLLGRKTIRQRLINIAENEGLSTKGQFWKSWGWCNSDSHPVTTGERKKFEAISLEEGEVAEEGTDSKRYKKRSIQTLDSEGLNVSQQLVTERALIDLLLPCIDQSSDDSRKAFANDLIKQLSNIEQQINAVTRGTDKQAGSAPSGIEGPTSKGNNRKVIKGGSPGLSRRPATSSADSALPSPAALRASMLLRLQLLLRLLPVICADGEPSGRNLRHTLASVILRLLGNRVVHEDVELSYSPIQTSLSKREVESLTEAASSVSTDLSGESLFDRLLLVLHGLLSSCHPSWLKSKPAPKSTNDYSKDVSIIDRELAETLQCDLDRMQLPDMIRWRIQTTMPVLLPSVRCFVSCQPPTIPNAALASLQSSISIPGSYSGNLITAQRNQFHLARPVANIAGKSKSLPLQDYDTEIDPWTLLEDGAGSGPSSSNSGLIGSGDHANLRASSWLKGAVRVRRKDLTYIGAVDDDS
Length2275
PositionKinase
OrganismParasponia andersonii (Sponia andersonii)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Rosales> Cannabaceae> Parasponia.
Aromaticity0.06
Grand average of hydropathy-0.228
Instability index48.08
Isoelectric point8.82
Molecular weight251254.93
Publications









Function






Annotated function


GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP19301
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     139.82|      49|     419|    1315|    1371|       1
---------------------------------------------------------------------------
 1315- 1371 (73.09/76.87)	LMDCIRQTG.....GAAQEGDPSLVSSAVSAIVgnVGPTIANL.PD..FRLGSgypngpSATDSL
 1739- 1795 (66.73/46.62)	LTDAIRSSSpspgkAAASENENNFIQIILTRLL..VRPDAASLfADvvHRFGR......SLEDSM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.37|      17|      18|      39|      55|       2
---------------------------------------------------------------------------
   39-   55 (33.09/19.37)	PLNSR.RPSLLSPYKLKC
   59-   76 (32.28/18.69)	PLNSRlGPPDFQPQTPNC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     133.68|      32|     419|     426|     462|       3
---------------------------------------------------------------------------
  426-  462 (48.53/44.78)	LPSCVVSHvvtdgSLSKSSSEDVRKIKIGSSEVS.SLF
  854-  881 (41.35/25.93)	LPST.........SL.KSTDAGLDEMQVGMKRSSvSLF
  910-  938 (43.80/28.01)	..SCLQGH.....SPTLSDEEDTWWVKKGSKSSD.SL.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     211.25|     100|     473|    1056|    1166|       5
---------------------------------------------------------------------------
 1056- 1115 (48.76/49.48)	..............................................................................................................................................................................................................................................................................................................................................................................................................................VGQpgrpFTSVDDRNGVRWkLGED...ELSTIMYLMDVSndLVL.....AVKFVLWlLPKVLGSPNST
 1116- 1166 (47.35/32.51)	IHGGRSSLLLPRNVESQVCEVGEAFLISSIRRYEniLIAQDlIPEALSAAM...............................................................................................................................................................................................................................................................................................................................................................................................................................................
 1530- 1589 (56.55/30.36)	...................................................hraatvlasngrvsgssvlvyaryllrrygnvasvvewektfkatsdkrlvselesgwstdgelnfplgvpagvedlddffrqkmsggrlsrvganmrdivqrnlnaedvlqhffgkerkvfaagtpkgpaaeklddgyqvaqriisdlmdcirqtggaaqegdpslvssavsaivgnvgptianlpdfrlgsgypngpsatdslnvarrilrihisclcllkealgerqnrvfevalateaslalavvfnpgkasrnqfqsspeshdsnssmsnenlnnstkvvlsrttkfaaavsaliigavvhgvtnlermvtvlrlkdgldivqfirstrsssngsvrsmgafkmdnfmevyvhwfrllVGN....CRTVSDGLTVEL.LGEPtivALSRMQSMLPVV..LVFppaysIFAFVIW.RPFILSSSLSV
 1593- 1640 (58.58/30.38)	INQLYQSLTLAINDAIKHLPFREACLRDGQGFYD..LVAAD.GSDAEFAAM...............................................................................................................................................................................................................................................................................................................................................................................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     106.39|      34|     157|    1643|    1700|       6
---------------------------------------------------------------------------
  212-  246 (54.17/24.20)	LRATWFIKVTYLNQIrPSSGS.VSGASD.KAQLSRSE
 1658- 1693 (52.22/44.03)	LRARLFLNAIIDCKM.PEDGNrVSGHGEsKTQLAETE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.94|      11|     157|    1643|    1653|       9
---------------------------------------------------------------------------
 1643- 1653 (20.65/10.67)	LGGSDLHLKSK
 1803- 1813 (20.28/10.33)	LGGSDVLLGRK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.94|      29|     162|     790|     818|      14
---------------------------------------------------------------------------
  790-  818 (47.97/25.64)	KQV..NKTRISARKQKF.....YTVSGKDGASSASV
  948-  983 (37.97/18.89)	KQVsrNRQKVPRKTQSLaqlaaSRIEGSLGASTSHV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     130.42|      42|      78|    1970|    2011|      15
---------------------------------------------------------------------------
 1970- 2011 (71.19/39.44)	SP...GLSRRPATSSADSALPSPAALRA.SMLLRLQLLLRLLPVIC
 2047- 2092 (59.23/31.55)	SPiqtSLSKREVESLTEAASSVSTDLSGeSLFDRLLLVLHGLLSSC
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19301 with Med12 domain of Kingdom Viridiplantae
Unable to open file!