<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19286

Description Mediator of RNA polymerase II transcription subunit
SequenceMNQVAVPKDPEEDESAAQSIELSKGSDKADSAGGGGGGGGGGGGGAAAVEEEDAVEKPHDPMEEDAVSPATVFCIRLKQPRSNLLHKMSVPELCRNFSAVAWCGKLNAIACASETCARIPSSNANPPFWIPIHIVIPERPTECAVFNVVADSPRDSVQFIEWSPTSCPRALLIANFHGRITIWTQPSQGSANVVRDATCWQREHEWRQDIAVVTKWLSGVSPYRWLSSKSSSGSNSKSTFEEKFLSRQSQNSARWPNFLCICSVFSSGSVQLHWSQWPPNQNSALAKWFCTSKGLLGAGPSGIMAADAIITDSGAMHVAGVPIVNPSTVVVWEVTPGPGNGFQTTPKTSTSNGVPPSINPPSWAGFSPLAAYLFSWQEYLISEAKSGKKQTDLEFGDTVQLHCSPVSNFSAYVSPDAAAQSATTTWGSGVTAVAFDPTRGGSVIAVVIVEGQYMSPYDPDEGPSITGWRVQRWESSVQPVVLHQIFGNPTSSFGGQAPMQTVWVSKVDTSIQPTNDFKSHQTTATGVTGPTSDVRKTSDSIVEKAKRVNFDPFDLPSDVRTLARIVYSAHGGEIAVAFLRGGVHIFSGPNFAPVDNYQINVGSAIAAPAFSSTSCCSASVWHDTSKDRTILKIIRVLPPAVPGSQDKANSSAWERAIAERFWWSLMVGVDWWDAVGCTQSAAEDGIVLLNSVIAVLDADFHSLPSTQHRQQYGPSLDRIKCRLLEGTNAQEVRAMVLDMQARLLLDMLGKGIESALINPSALVPEPWQASAETLSGIDPEAIAIEPSLVPSIQAYVDAVLDLASHFITRLRRYASFCRTLASHAVTAGAGSNRNMVASPSQSSSSPATNQGGQSGTTNSTGSTQMQAWVQGAIAKISSTTDGVSSSAPNPISGPSSFMPISINTGTFPGTPAVRLIGDCHFLHRLCQLLLFCFFFRRTQLPRFTGPSQRNTDTSVQKPQSGPPGKVEEMGSAPTKPLSVVRTDENQVARAGQVMPGAKAVEEGSSGRSRLGSGNAGQGYTFEEVRVLFLILIELCRRTSGLAHPLPVSQVGSSNIQVRLHYIDGNYTVLPEVVEASLGPYMQNMPRPRGADAAGLLLRELELHPPAEEWHRRNMYGGPWSDPDDIGSLDDTPKLSNSVDPLDFSSLESCNVYYGTQGLWPRKRRMSERDAAFGLNTSVGLGAYLGIMGSRRDVVTAVWKTGLDGVWYKCIRCLRQTSALATPSATNPLNQNDREVWWISRWAYGCPMCGGTWVRVV
Length1256
PositionTail
OrganismParasponia andersonii (Sponia andersonii)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Rosales> Cannabaceae> Parasponia.
Aromaticity0.08
Grand average of hydropathy-0.203
Instability index45.33
Isoelectric point6.13
Molecular weight135090.51
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process
regulation of transcription, DNA-templated	GO:0006355	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP19286
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     281.59|      70|      95|     395|     464|       1
---------------------------------------------------------------------------
  395-  464 (123.73/71.10)	FGDTVQLHC..SPVSNFSAYVSPD.AAAQSATTTWGSGVTAVAFDPTR..GGSVIAVVIVEGQYMSPYDPDEGPS
  493-  557 (109.86/62.26)	FGGQAPMQT..VWVSKVDTSIQPT.NDFKSHQTT.ATGVTG....PTS..DVRKTSDSIVEKAKRVNFDPFDLPS
  570-  620 (48.00/22.84)	HGGEIAVAFlrGGVHIFS...GPNfAPVDNYQINVGSAIAAPAFSSTSccSASV.....................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     358.13|     105|     113|     805|     916|       4
---------------------------------------------------------------------------
  107-  145 (37.87/13.07)	........................................................................NAIACASETCARIPSSNANP...P.FWIPIHIVIP...ERPTECAV......
  805-  916 (173.59/115.35)	HFITRLRRYASFCRTLASHAVTAGAG.SNRNmVASPSQsssSPatnQGGQSGTTNSTGS..TQMQAWV...QGAIAKISSTTDGVSSSAPNPISGPSSFMPISINTG...TFPGTPAVR...LI
  920- 1030 (146.68/82.00)	HFLHRLCQLLLFCFFFRRTQLPRFTGpSQRN.TDTSVQ...KP...QSGPPGKVEEMGSapTKPLSVVrtdENQVARAGQVMPG.AKAVEEGSSGRSRLG..SGNAGqgyTFEE...VRvlfLI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.72|      26|     455|     630|     664|       5
---------------------------------------------------------------------------
  632-  663 (38.44/39.48)	KIIRVLPP....AVPGSQDKANSSawERAIaerfWW
 1208- 1237 (46.28/18.67)	KCIRCLRQtsalATPSATNPLNQN..DREV....WW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.11|      10|     940|      92|     101|       6
---------------------------------------------------------------------------
   92-  101 (19.05/13.24)	ELCRNFSAVA
 1033- 1042 (19.06/13.25)	ELCRRTSGLA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19286 with Med16 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FTGPSQRNTDTSVQKPQSGPPGKVEEMGSAPTKPLSVVRTDENQ
2) MNQVAVPKDPEEDESAAQSIELSKGSDKADSAGGGGGGGGGGGGGAAAVEEEDAVEKPHDPME
3) SNRNMVASPSQSSSSPATNQGGQSGTTNSTGSTQ
943
1
831
986
63
864










Molecular Recognition Features






MoRF SequenceStartStop




1) MNQVAVPKDPEEDESAAQSIELSKGSDKADSAGGG
1
35