<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19285

Description Tyrosine-protein kinase
SequenceMKLLKPSHPPSHGPSTESLSGFSSPASFQLGFDRGASSQLPEIVEDDANKVVHVAVGKSVEKAISLLNWTFRRFEGKGVCILHVYRPSQLIPTHCESLLLGKLPASQANLEVVSTYRKYEREETTKLLQIYLSICSGAKVSASIITIEADQVQKGIVNLVNKHGIRKLVMGAVPENCMKVKKSSSKAYYAATNAPLFCEIWFINKGKHLWTRDSSEDPSSLPSCSQPQLATVGNSIFRSFQYGKNKSIQANWLRSNSARSAISAEISNRIQCEPVHVDLASSSTLSCSTSPCLHDLNDSFSPASTGSGYYSGERRVSSDSDEEKLYSHLIDARIEAKASRNEAFEDLLKLRKLESEAREAISKVKGFESALAREVKLREEADDALKTTVEEQEKLLEEREDITLELRRTMRNVALLDSRAQEANRRHDEAAGELKLVQESIATLRQEKQQIRKQKMEALHWLERWRNRGQGGAANCTGLIGFIDELPELAEFSLSDLQTATCNFSESFKIGKGGFGCVYKGEMLGRTVAIKKLHPYNMQGESEFQQEVKVLGKLQHPHLVTLLGVCPEAWSLVYEYLPNGSLQDHLFRKNNVLTWEIRARIIAEIASALCFLHSSKPEKIVHGDLTPRNILLDSALSCKICDFGICRLINEDNLHCPSLRWTNGPKGAFSYTDPEFQRIGILTPKSDAYSFGLIILQSLTRRSPVGLTGEVRKAVSSGKLASILDSSAGEWPTLVVRRLVELGLQCCELNGRDRPEITPSLVRELEQLHGSEERPVPSFFLCPILQEIMHDPQVAADGFTYEGEAMRGWLENGKETSPMTNLKLGHLHLTPNHAIRLAIQDWLCKA
Length846
PositionTail
OrganismParasponia andersonii (Sponia andersonii)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Rosales> Cannabaceae> Parasponia.
Aromaticity0.07
Grand average of hydropathy-0.332
Instability index47.08
Isoelectric point7.09
Molecular weight94222.38
Publications









Function






Annotated function

Functions as an E3 ubiquitin ligase.



GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-UniRule
protein kinase activity	GO:0004672	IEA:InterPro
ubiquitin-protein transferase activity	GO:0004842	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP19285
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.99|      11|      14|     278|     289|       1
---------------------------------------------------------------------------
  278-  289 (14.99/12.81)	DLASSSTlSCST
  295-  305 (20.00/11.91)	DLNDSFS.PAST
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.48|      20|     267|     223|     244|       2
---------------------------------------------------------------------------
  223-  244 (34.57/27.23)	SCSQPQLATVGNSifRSFQYGK
  493-  512 (36.91/22.66)	SLSDLQTATCNFS..ESFKIGK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.48|      22|     267|     538|     559|       3
---------------------------------------------------------------------------
  538-  559 (40.13/23.38)	MQGESEFQQEVKVLG..KLQHPHL
  806-  829 (37.35/21.32)	MRGWLENGKETSPMTnlKLGHLHL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     156.81|      47|     559|      50|     104|       7
---------------------------------------------------------------------------
   50-  104 (69.18/74.24)	KVVHvavGKSVEKAISLLNWTFRRFEGKGVCilHVYRPSQLiptHCESLLLGKLP
  619-  665 (87.63/65.50)	KIVH...GDLTPRNILLDSALSCKICDFGIC..RLINEDNL...HCPSLRWTNGP
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19285 with Med32 domain of Kingdom Viridiplantae
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