<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19279

Description Uncharacterized protein
SequenceMTSRTPIGVHPRPPQRTISSSTLPPVQRPPPQRALSQQLFPSSPVRKDSALSDASSDSIDHFQAQTHGQSTTQAQSHARLVTTPRRAGSRLRLELSNVDPPHGTSALLSATASATASAPTSAASSPQSHTTSRVPSMADGGDVGDSSPTPTRASAADLDNDNIPLPMPKRRLPASQTYSKLSKRVEAPPRPAPALKKDGRPKPWTVEVPKDAPRYPPAEKRPPPTSDDRFARSGDPFSRGLYSGYADFFPWHGTKDVKHHEDDWSQEAIQKGTWDRGSQNETGTARMTISPAIKQKPGLGALSTIFMGILNQRRLRGHVTAPSTFKPPPRVTLTDTKREVWMRDLANPAISLRRLSRTIPHGIRGRTLLDQCLNKSVPTERAVWLAKCVGANEIRAFKRKGAPGGGAFAIAGEFKWIRDWTVFVEQFIESTTFSFGEPDWKAKVTYAIRLATSFYAEQLLDRDHYLDWITSGLEHSPQSKLPMWILIAQICWADILRSRKYGRRLVYALLGHLHTIYIHPDKDILIQLSSQLSTLLASLVRDKSDSFIDPSLWAKHRDALDASLPRDDKASRDAYSHINTRNGQVSITSNTSPLAGRPQLVRLLDATLLSQINRDLPQKCWATGDDKTDIVKTTVDWATSFYRPGLARVYIAANLIRVWASLRIDVTGAILEHMDTIPADDEGRKQMAYHLVVELVRTGQFSVTQYIKWLMARGGCSHPSEVNSDEAPCTTRLLVHLPVHYLTEDQKDDRSNLLRRAANYSVIEEADDIHNALMCVSHTLGLPMQDNDMSGRKPIPLRKLLPMIVNSSRALRCAVGVHLRDSVMRLNKSVQAMSQRLFSAIRTILEATQDFYALCEILKFCSRTTNIEVLASCVETLNLNLQVFYAQGTAERLFTVFFERLKAINQEQGLVSRPLLASLCSLSRRMPNRQEISKILAHELFLNDRNNATDACSPVSDNNMANPLSGADGEVSEQIEKLLASGNSIDHPTMNRLFAYIIRRLELGWAKMDDNRRIHASLLTRLRLFDAQHFDKLMSDWVGRVRLMKKREKLHAVFPLLIITDALPVSFLFGPTSLTPAPAPQGDAESAGAAPPDLSSPGAATFHQELLHLTLSKLPDDTDLSQEEVYRFGICQQSIHFSHHKGLLSLIRHAIIEYAELRAGDGNVKLPLDDVAYRNRILDALQLLVVMHTADVTEAFSVQKVHPGAFRLIHEIISNLFKQRGAKDRSSLTAPYDEILRQTNELTMPFCQIKLNMDLSVTPPRQTESENAPQSVSQYDLFAQAMDRAIGAQNVMWTTMLPCLSKDISRHLQSQARQRFLALVPASSQLKDPENTQSALSSNNNLYLAEKLLGVIEAIVVGQQPPPTAQLTMALANKLSDLVDLVVAPRAAGDKKGGMLSSVVEHWIPMLLKFVLLHSVSQEPLSASVMTTSVQGKLQMPPHHEARAHTVLTLCRLLLGLETLPSQVAGGGLLQHLFDVAAVLADGLPDDLRLHCAKSVLVVPGMMPSLHTSSDFRLYYIFSIPPPTAMDGMMLAHRDKAAVPHSSASRGMGAMYGIRPLPHERLSPYVIRRWELLSEPTPNVGVNDTSLNLSLFEAIRIH
Length1598
PositionKinase
OrganismTrichoderma gamsii
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Hypocreaceae> Trichoderma.
Aromaticity0.06
Grand average of hydropathy-0.270
Instability index48.71
Isoelectric point9.08
Molecular weight177221.85
Publications
PubMed=26893428

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP19279
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     210.47|      68|     295|     251|     417|       1
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  180-  249 (114.36/35.34)	KLSKRVEAPP..RPAPALK.KDGRPKPWTVEVPKDAPRYPPAEKRPPPTSDDR..............................FARSGDPfSRGLYSgYADFF
  314-  414 (96.11/158.27)	RLRGHVTAPStfKPPPRVTlTDTKREVWMRDLANPAISLRRLSRTIPHGIRGRtlldqclnksvpteravwlakcvganeiraFKRKGAP.GGGAFA.IAGEF
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     418.83|     142|     299|    1056|    1280|       2
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  712-  883 (206.04/108.73)	ARGGCSHPSEVNSDEAPCTTRLLVHLPVHYLTED...............QKDDRSN......LLRRAanysVIEEADdihnaLMCVSHTLGLPMqdNDMSGRKPIpLRkllpmivnssrALRCAVGVHLRDsvmrlnkSVQAMSQRLFSAIRTIL......EATQDFYALCEILKFCSRTTNIEVLASCVETLNLNLQV
 1084- 1257 (212.79/252.80)	AESAGAAPPDLSSPGAATFHQELLHLTLSKLPDDtdlsqeevyrfgicqQSIHFSHhkgllsLIRHA....IIEYAE.....LRAGDGNVKLPL..DDVAYRNRI.LD...........ALQLLVVMHTAD..vteafSVQKVHPGAFRLIHEIIsnlfkqRGAKDRSSLTAPYDEILRQTNELTMPFCQIKLNMDLSV
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.95|      14|      15|      10|      24|       3
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   10-   24 (24.35/14.17)	HPrPPQRTISSSTLP
   28-   41 (27.59/12.08)	RP.PPQRALSQQLFP
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     148.65|      43|     158|    1361|    1434|       4
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 1361- 1403 (76.81/66.53)	PPPTAQLTMALANKLSDLVDLVVAPRAAGDKKG......GMLSS.VVEHW
 1521- 1570 (71.84/24.20)	PPPTAMDGMMLAHRDKAAVPHSSASRGMGAMYGirplphERLSPyVIRRW
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     137.38|      43|     299|     251|     299|       5
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  251-  299 (70.55/57.97)	WhgtkdVKHHED.DWSQEAIQKGTWDRGSQNETGTARMTI....SPaIKQKPGL
  553-  600 (66.83/39.74)	W.....AKHRDAlDASLPRDDKASRDAYSHINTRNGQVSItsntSP.LAGRPQL
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     130.88|      45|      97|     886|     936|       6
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  886-  936 (66.95/72.31)	AQG......TAERLFTVFFERLK...AINQEQglvsRPLLASLcsLSR.RMPNRQEISKIL
  980- 1034 (63.93/49.20)	ASGnsidhpTMNRLFAYIIRRLElgwAKMDDN....RRIHASL..LTRlRLFDAQHFDKLM
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.52|      16|     185|     435|     459|       8
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  444-  459 (27.80/38.28)	VTYAIRLATSFYAEQL
  631-  646 (30.72/14.12)	VKTTVDWATSFYRPGL
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.55|      28|     777|     522|     550|      17
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  522-  550 (41.47/30.63)	KDILIQLSSQLSTLLASLVRDKSDsFIDP
 1302- 1329 (48.08/31.11)	KDISRHLQSQARQRFLALVPASSQ.LKDP
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19279 with Med12 domain of Kingdom Fungi
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