<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19278

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMETGEYETNTLSINSVSSITYRLYEASPNLSQTFASVALEIENSLRDRGYIVLYDAARRGLWHFLFLTKEEEENLDKVGDSLGLPLDVLEQGLVVKEEGVIEPPIMPKPRSQALQSGNTPAGLLSANPTLEQAHRPALSSPLQTTTPSSQDHEFKAEHNIKTTPQSLLYEKLITAVSLTVSTAFCRRTGAIPLNYRTILISPTTYSAQPHGVAIGRPQILGTFRVYLTTTGALVIGISLTKCKGILSLDDTAASSLAPAGYSILAAPFGIMTATQNFVPGDGGLSSLAQTPMTHFFSFRNGLDGQESLWKQACQRFLDFRGIAASTLGGCLWVNLLVPKSKSADSKGDYRPSGANSSFTLPWPRRLCFRKKNVDASSTSRVIDTVLSGHEESHDPLGNAKGWHSSITEREEKIKRAAERAAAIPKDSHPQTADSKTPKPSGLSPVALQRPNTATAGIMYPTPPDGVQQPNGVTPSMDGTFSSPGNPLSAQIIPEADITMQNEQAGGMGLDQSPTVAESKRRRSDNLLGDTDNVLGGDVSGDIFDDNDITEADFNFFDEKPDDIDIDMAMGDLPSSEMALSQAAEESVRPVETIQQPLAPTPASLPPSAPSLPPSTPTPVPAVSPTSAPASALQAVISLPPPPPPPPPPPPPPQKETAVFAKPELKHARSQNEDAARRNRGDIRVTPAKRESSPFDPHAVFKRVKASLKRPKYDASVPAQPHWRKEKVFESLDFDPAIPMISKKYEQGGFFDLSALTKVERMEKANGDVPAVPETDYLKRHGKHNRKPRDRSTARHTIGKQYFAMEPQILTTTSPMKLDGSISDREDGDMESDQDDSSYTSDEPGSPHKASIRLMIGDDDIMSQITSLRDCDIEEPDHQLAMELPRLSRSDISGVSLSQLFLDPEPLLLDMGLSDEDVIQVAQLVADQAATGSLDIFNASDFEPATLSASEKRSDLSIHARDAFYTLEGIITHFFEDAMPVRLKGLLDIQDLPILSQFIPRQITGREGNSETMRPSNLYQIPSPHLEVQRADTKLSVLPSAVAFWESLGLSPSSGSKNINAICVFPGWSGMGDNVKAFMDRVKSIYELLKLGTFEVMPLGEDVEAGLLPYEVDRITTSPDATVTRHGSAMVECMEALRGVFSNLAITETNFVIYFVYSPENPGTIIESCTAFQRFYELYQKILASRKEPPQNELVLQLVSTDVLSSPSALVITQTSDLVRLCIETYDRCTLFGGPMPAPAIRLEQLLPRIIDFKLTTTPSASLIRENSCIHVAYSQSVDERWVTAAWTDDRGNQQATAAYCMGRKGKSPSRNMTEIANEIWETTLELMSSWRVLWRVIITKCGPMPQHEVDFWVDLARTEIHAKVTLVLLSVDSSPSLQLLPPAIKLPAPIAALHTPVSTPQPSMQSPEPVATPATPAANAAAATPSNDGTGTAEAESDEILIDVTDQTWGAIAGHRLSNSSSILEVQLSLMSGYLIKRTGLRLEDPPVVMEVNLIYTETIPRVHEPLLREMLGYFRALGTLARARGVVDKEGDVRPWHVAAAEKAVRALYLLM
Length1553
PositionKinase
OrganismTrichoderma gamsii
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Hypocreaceae> Trichoderma.
Aromaticity0.06
Grand average of hydropathy-0.290
Instability index52.78
Isoelectric point5.14
Molecular weight169331.75
Publications
PubMed=26893428

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP19278
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.38|      17|      22|     251|     272|       1
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  253-  272 (25.37/26.07)	ASSLAPA..GYSILA.APfgiMT
  274-  293 (23.01/ 7.23)	TQNFVPGdgGLSSLAqTP...MT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     207.12|      55|     221|    1010|    1076|       2
---------------------------------------------------------------------------
  436-  475 (43.32/15.55)	.TPKPSGL....SP.VALQRPNTATAgiMYPTPPdGVQQPN.....GVTPS..............
  585-  639 (70.93/30.03)	ESVRPVETIQQP.......LAPTPAS..LPPSAP.SLPPSTptpvpAVSPTSApASALQAVISLP
 1010- 1065 (92.87/66.88)	ETMRPSNLYQIPSPhLEVQRADTKLS..VLPSAV.AFWESL.....GLSPSSG.SKNINAICVFP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.59|      25|      32|     659|     690|       3
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  659-  688 (31.40/39.96)	FaKPelkHARSQNEDAA.RRNRGDIRVtPAK
  694-  719 (41.18/22.69)	F.DP...HAVFKRVKASlKRPKYDASV.PAQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.70|      16|     206|     727|     743|       4
---------------------------------------------------------------------------
  727-  742 (30.28/15.19)	VFESLDFDPAIPMISK
  935-  950 (27.42/ 8.91)	IFNASDFEPATLSASE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.55|      32|     468|     875|     907|       5
---------------------------------------------------------------------------
  875-  907 (51.37/41.04)	PDHQLAMELPrLSRSDI.SGVSLSQLFLDPEPLL
 1345- 1377 (50.18/34.61)	PQHEVDFWVD.LARTEIhAKVTLVLLSVDSSPSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.05|      17|      18|     132|     149|       6
---------------------------------------------------------------------------
  131-  148 (26.18/21.11)	EQAHRPALSSPLQtTTPS
  149-  165 (28.87/18.11)	SQDHEFKAEHNIK.TTPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.32|      21|     615|     478|     498|       7
---------------------------------------------------------------------------
  478-  498 (40.05/24.78)	GTFS.SP.GNPLSAQIIP.EAD.IT
 1091- 1115 (22.27/10.12)	GTFEvMPlGEDVEAGLLPyEVDrIT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.67|      13|      20|     294|     309|       8
---------------------------------------------------------------------------
  294-  309 (19.48/19.71)	HFFSFRnG.....LDGqeSLW
  315-  332 (23.20/11.22)	RFLDFR.GiaastLGG..CLW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.88|      19|     221|     540|     560|       9
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  524-  542 (31.97/21.17)	DNLLGDTDNVLGGDVSGDI
  545-  563 (33.90/15.53)	DNDITEADFNFFDEKPDDI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19278 with Med13 domain of Kingdom Fungi
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