<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19277

Description Mediator of RNA polymerase II transcription subunit 4
SequenceMREFEAGDSRARFWPEALTKPILNFDAQSYDPILTPHTSYDPVETSLVSLSRSPVRAYTSTKDYAVYPSSRAINKMDTYIDTRFERLEKALANLIDSVTKYHPSTVQAEELKTADDELCKGLEEVQTHQNNHLKIQQLRQLSTSLDSQIRETLTSLATTRKDIVTTQVTVYPSEPNYPIVYEELLSYARRISKTSMPPSAILNALASTTQESQTPLPDSQAQAGMTPSAQTPNPTQSPAPINGVLPDPSTQQTQTSQLTSLPENMSQFLNPLSGQLFFPWPLEDKIRSGALASNQILLEQGIDPKGYDPVAEEERKRKEEEERKEKEEKEKQERAERERERREELERLRKEDLLRREKEQAAFRRASTAAGISGDAAINAPPSARPEKKQFQFTNLDDLDDDDDED
Length406
PositionMiddle
OrganismTrichoderma gamsii
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Hypocreaceae> Trichoderma.
Aromaticity0.06
Grand average of hydropathy-0.892
Instability index57.02
Isoelectric point4.91
Molecular weight45974.42
Publications
PubMed=26893428

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364141
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP19277
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.62|      25|      28|     209|     236|       1
---------------------------------------------------------------------------
  209-  234 (44.36/39.63)	TQESQ....TPLPDSQAQAgMTP.SAQT..PNP
  250-  281 (34.26/17.69)	TQQTQtsqlTSLPENMSQF.LNPlSGQLffPWP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.77|      30|     102|      38|      69|       2
---------------------------------------------------------------------------
   38-   69 (47.73/42.57)	TSYD.PVETSLVSLSRSpvRAYTSTKDYAVYPS
  143-  173 (46.04/33.19)	TSLDsQIRETLTSLATT..RKDIVTTQVTVYPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.60|      23|      23|     311|     333|       3
---------------------------------------------------------------------------
  311-  333 (39.05/26.68)	AEEERKRKEEEERKEKEE...KEKQE
  335-  360 (34.55/22.73)	AERERERREELERLRKEDllrREKEQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19277 with Med4 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GALASNQILLEQGIDPKGYDPVAEEERKRKEEEERKEKEEKEKQERAERERERREELERLRKEDL
2) PSAILNALASTTQESQTPLPDSQAQAGMTPSAQTPNPTQSPAPINGVLPDPSTQQTQTSQLTSLPENMS
3) REKEQAAFRRASTAAGISGDAAINAPPSARPEKKQFQFTNLDDLDDDDDED
289
198
356
353
266
406










Molecular Recognition Features






MoRF SequenceStartStop




1) RASTAAGISGDAAINAPPSARPEKKQFQFTNLDDLDDDDDED
365
406