<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19276
Description |
Mediator of RNA polymerase II transcription subunit 18 |
Sequence | MYELFLTALVEDSDINTALAVLSGFCSMQPWESVSRVLYFQGPPRPSGFANQRSFEKPMRKDAALLWKELHQNLSRQSFVLQARYEILKDRDLGPQAESVDLNLVPGILRWTDFPDPPRGQPILAQRKKVELWEQRKLPSILQENNYQFKTETVEETYRFFRDEVEFCLTRHYFVGPIDDYVPLANMPAAPKGPKSSLPAWDSLTRVDMQSRWILQVKAHVVQDNKPDEIKKAQDQLLKFRADLDGVFDFKVIDRKVHDTRVAMQQQGVQALPQKVLLGKS |
Length | 281 |
Position | Head |
Organism | Trichoderma gamsii |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes>
Hypocreomycetidae> Hypocreales> Hypocreaceae> Trichoderma.
|
Aromaticity | 0.10 |
Grand average of hydropathy | -0.482 |
Instability index | 46.67 |
Isoelectric point | 7.73 |
Molecular weight | 32503.87 |
Publications | PubMed=26893428
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364150
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP19276
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 166.99| 47| 79| 94| 145| 2
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55- 83 (36.09/13.75) ....................FEKPMRKD.AALLWK...EL...HQNLSRQSFVLQA
94- 145 (77.25/48.22) GPQAESVDLNLVPGIlrwtdFPDPPRGQ.PILAQRKKVEL...WEQRKLPSILQEN
176- 216 (53.64/24.98) GPIDDYVPLANMPAA......PKGPKSSlPAWDSLTRVDMqsrW.......ILQ..
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