<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19270

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMPLMMDDDMEVDIDDLFGDGAGGLLPPSRPPPKELFQRVDELRGSGCCQSIAWSRWGSIASITSNGLGLEFRNLRIHPKDGSWDLSDPTIIPQIAPIADGGQLKHLCWSPNGADLAAIDSAGRIAILNLAQSLNKPTFTRNSNVGPIEDLRAVVGAYWLNLSPSNVRQPGIQSVAVKTSTDYRYEISQAIAFGPCFPNAHKSALITVSTGGSLSLLWPQADGKWHELSSDIESISSSDDLITHASICADKNNTLLLAFATTAKKLSIARIAIKWGSPTANPPDRPVNPALNTVTPTIIIRLLSDTNWMDGSATDASDPFHLSPSMAALSHLSILSPSPDGPGGRPTSPTVITIRSHLPNSMSQYNQDTHSLINRWELSEASPSVHPAFEQLSARRNSVGSKPGPSPSLKKQEGFTSNKVVIWIEAIYFERIICFGYSDGSVEYRDRTSLAELFTLGGLDKFSHISQIGFTYNGYEPSLVGALSPTHLSVVQKGCDGKIKWNPLVYNMGEIGTSLEDTQYAAVIAGFSMACSTAIMNSSNHDDLMAAASKFKHLSSFAFDLVSEVSKTLKFNVDYSEESHHDSLIRNPSIQISLSIQNALGYNGDAHKRTFESKIAWISLQLRNCVVLITMAMNIRVPIPDQQKKVLGLEDSEVIRLLAGSVRWCLDLMSWLIDCLLHPEDPEVFESVTKGEDGSIPLLSAHLLATNNIALHVLLSSATRGFLTGICRRLAHLDYTARKAMSAAQSVSAPPGQSAPLISNSLRSSYTAIATLTASSIVPISRFEAFVARIADVVKEAYTAAKFPSQQQAQGAPGDSKRNNVEQGILFGAPLPEVMAPAISRIFSEELPKLRAEIDPSRLFFHDFGILGLPESNASAGKGAAEGSATTSSAQYRVNHTIDIFSRVPIQLGMEPEEAQGIDARGSRPGRRWRRCVRCAAAMEDIHSLTPPVQFLIMQQRRCYCGGNWDILAGARVVA
Length974
PositionTail
OrganismPseudogymnoascus verrucosus
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Leotiomycetes incertae sedis> Pseudeurotiaceae> Pseudogymnoascus.
Aromaticity0.07
Grand average of hydropathy-0.111
Instability index47.98
Isoelectric point6.14
Molecular weight105562.69
Publications
PubMed=29295979

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP19270
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     263.69|      82|     219|     115|     332|       1
---------------------------------------------------------------------------
  181-  266 (131.47/281.48)	DYRYEISQaIAFgpcFPNAHKSALITVSTGGSLSLLWPQADG..KWHELSSDIESISSSDDLITHASICA............DKNNTLLLAFATTAKKLS
  459-  554 (132.22/43.79)	DKFSHISQ.IGF...TYNGYEPSLVGALSPTHLSVVQKGCDGkiKWNPLVYNMGEIGTSLEDTQYAAVIAgfsmacstaimnSSNHDDLMAAASKFKHLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.58|      22|     217|     587|     614|       2
---------------------------------------------------------------------------
  587-  614 (30.60/39.29)	PSiQislsiQNALGYNGDAHKRTFESKI
  803-  824 (40.99/30.10)	PS.Q.....QQAQGAPGDSKRNNVEQGI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     179.95|      50|     217|      85|     164|       3
---------------------------------------------------------------------------
   85-  135 (82.77/40.88)	LSDPTIIPQIAPIADGG.QL..KHLCWSPNGA..................DLAAIDSAGRIAiLNLAQSLNK
  302-  331 (42.96/13.63)	LSDTNWMDGSA..TDAS.DP..FHL..SPSMA..................ALSHL.................
  680-  748 (54.22/10.16)	..DPEVFESVTKGEDGSiPLlsAHLLATNNIAlhvllssatrgfltgicrRLAHLDYTARKA.MSAAQSVSA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.79|      10|     314|      19|      30|       6
---------------------------------------------------------------------------
   19-   30 (17.34/14.06)	DGAGGllPPSRP
  339-  348 (22.44/11.66)	DGPGG..RPTSP
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19270 with Med16 domain of Kingdom Fungi
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