<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19258

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMSSRNSMGVPQRAQQRALTGSALHAHQRSISSSHIQPHSPVRKEAFADHNQPTDPSDVATASSQATTASRHGATPRRAAGSKLRIELSNDDNVTPGPATDSPQATPSITSHSAAPDSSTDVSGHGSPALSRASHADSAIPRMPMPQRRGPLQRFVASSKTPAPPTAPLKRDSKPKQYSIEVPLDAPRFLSTNKQDAVHRDPFNKGLFSGNADFFPWTGRHHEDEWSTEAIQKGTWDRGSQNETSSARLAVYPSLKQKTGLNALSTIFMGVLNQRRNRGQITAPSTFKPPPRVTLTDTKREVWLKDLANPTISLRRLSRTIPHGIRGRTLLDQCLNKNVPTERAVWLAKCVGANEIRAFKRKGVAGALVLGNELKWIRDWTIFIEQFVDAVVSSVGEPDWKQRVTYSIRLATVLYSEHLLDRDHYLDWIISGLENSSQAKLPMWILIARICWTDILRSRKSGRRLVFALLNHLNTIYNDLDRDILMPLSNQLASLLKTLVVNNPESFIQPLQWLKYRESLSAFLPPDASVLQQAYRSINQRNSELLVSSTASPPIGGKEHLVKLLDATLHGKVDRDLSTKCWSISEDKTQVLKTVIEWVTSFHRPGLEKIYTATNLLRSWGSFRINTTGAILDALDSIEPDDIVRKQAVYRLVTELARTGHFSISQYIQWLIARGNCHSAADVEDTGPCASRLLVELPVHCIPEDRKLDRANLLRRAANYDVADEARDIEIAIKCVSQTLGLPGYNIKHDDPALPSKPLPLRKLVSRINSSSFALKSALGTHIRDAFQRLLPPRLDADISLNVFTSTRTILETTRDFSMLGEVIRSCSKISNIEVLAACVDTINVNLQILLAVGIADDLFTLFFERLKAASREHGLVARPLLAALSSLAQRMPNQGEMAKNLQQELTQTDRSNPIDACSPVSDNMVSQSTSPEGEVSEQIDRLLATGNSVDHPTMNRLFRHIVPRLEAGWNKLDASRRVYASLLARLRIFDTPHFDKLMSDWVSHIRSLKERPALLELLPLLVSLGCLTMATVLHTANAAPVAANVNAIESGPPRGSAIYLEELLQLILRKLPQKSPLTADESYRFVVYQQSAKIEHSKALLLLIRNAVQEYSILRCRFSTTAPPLDDRSSQDDVLEALRVLVVTEPTAAAEALSMKDLAPEASALIRAIAAKLLAPGDENTSSSFDKILGLANELTMPFCQLSLSMELSLPQDSRNGNEADSQFDVFARAMDSAIEARNIMWTSMLPCLSDDITQHLRSQAHGRFLDMIPSSKAPNLTELATSEDRIQLAKNLLGVIEAIISGQPPSKSAQLTSMLVDKLTDLWEIISSHETSAARDAVRKHWLPFLLRFITLHSIYSSSSADVSTPTAASASGASSTVVNKNVNNVGAPATTTTATNSITNTNNEARARIVFVLCGILFALEAQQTLPPDGKLAQQVFDIALLLVDALPDDLRLHCARGVLANPSAVPSGPMASTATSSRGGTSDSRIYYLFSAPRPTAADNLMLAHRDKSAIPLSAAARGLGAMYGIGPTLQERYSHFTFRRWEALSEPTPNVGENDTSLSLGLFEAIKIQ
Length1573
PositionKinase
OrganismBeauveria bassiana (White muscardine disease fungus) (Tritirachium shiotae)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Cordycipitaceae> Beauveria.
Aromaticity0.06
Grand average of hydropathy-0.220
Instability index45.23
Isoelectric point8.78
Molecular weight172944.00
Publications
PubMed=27470140

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP19258
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     249.94|      62|     159|     452|     513|       1
---------------------------------------------------------------------------
  452-  513 (105.40/70.59)	TDILRSRKSGR.RLVFALLNHLNTIYNDLDRDI...LMPLSNQLASLLKTLVVNNPESFIQPLQWL
  556-  604 (56.28/33.90)	.........GK.EHLVKLLD..ATLHGKVDRDLstkCWSISEDKTQVLKT.VIEWVTSFHRP....
  613-  670 (88.25/57.78)	TNLLRSWGSFRiNTTGAILDALDSIEPD...DI...VR..KQAVYRLVTELARTGHFSISQYIQWL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     247.52|      78|     550|     674|     997|       2
---------------------------------------------------------------------------
  912-  997 (121.14/392.31)	NPidACSPvSDNMVSQSTSPEGEVSE.QIDRLLatgnSVDHPTM..NRLFRH....IVPrLEAGWNKLDASRRVYASLLARLRIFDTPHFDKL
 1464- 1548 (126.37/ 9.37)	NP..SAVP.SGPMASTATSSRGGTSDsRIYYLF....SAPRPTAadNLMLAHrdksAIP.LSAAARGLGAMYGIGPTLQERYSHFTFRRWEAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     120.84|      37|     321|     693|     814|       4
---------------------------------------------------------------------------
  161-  199 (61.65/ 8.19)	PAPPTAPLK.RDSKPKQYSIEVPLDAPrfLSTNKQDAVHR
  751-  788 (59.20/45.81)	PALPSKPLPlRKLVSRINSSSFALKSA..LGTHIRDAFQR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     131.75|      45|     321|    1001|    1051|       5
---------------------------------------------------------------------------
 1003- 1051 (59.70/49.96)	SHIRSlKERPALLE.LLPLLVSLgcLTMATVlHTANAAPVAANVNAIESG
 1329- 1374 (72.05/36.99)	SHETS.AARDAVRKhWLPFLLRF..ITLHSI.YSSSSADVSTPTAASASG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.65|      14|      18|      95|     108|       7
---------------------------------------------------------------------------
   95-  108 (26.83/15.31)	PGPATD.SPQATPSI
  115-  129 (21.82/10.84)	PDSSTDvSGHGSPAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     100.82|      33|    1088|      53|      94|       8
---------------------------------------------------------------------------
    2-   52 (46.07/42.08)	SSRNSMGVPQRAQQRALTGSALhahqrsissshiqphspvRKEAFADHNQP
   62-   94 (54.75/29.72)	SSQATTASRHGATPRRAAGSKL..................RIELSNDDNVT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.56|      12|     896|     523|     534|       9
---------------------------------------------------------------------------
  523-  534 (22.57/13.75)	LPPDASVLQQAY
 1428- 1439 (22.99/14.17)	LPPDGKLAQQVF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19258 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MSSRNSMGVPQRAQQRALTGSALHAHQRSISSSHIQPHSPVRKEAFADHNQPTDPSDVATASSQATTASRHGATPRRAAGSKLRIELSNDDNVTPGPATDSPQATPSITSHSAAPDSSTDVSGHGSPALSRASHADSAIPRMPMPQRRGPLQRFVASSKTPAPPTAPLKRDSKPKQYSIEVPLDAPRFLSTNKQDAVHRDPF
1
202










Molecular Recognition Features






MoRF SequenceStartStop




1) KLRIEL
2) RAQQRALTGSALHAHQ
3) RIYYLF
82
12
1488
87
27
1493