<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19256

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMDSQPSAARAALQEAVKYWSDFVARCIVQRLDSNRFQDFVHLVHARHPLPPVLVADLFLRPQPSNRVSLDPRIPPYVRILAQLRYVDAPSILRVLYKYSALHAHDRPPLPLPSSLPENGGDGEMMKKEEDEEKGAVGAGGVMRQDKMVRWQESAWAEEVLFYHVIKTMFEGTAFTDAKTGLELVDITCKWMDLFVHASSELATDMLANKHDRQARDEMETVRAALVPLLLRLVDNHELLRIISKPFAKGEENWQAMAAYLGNFLQTVQPPPLYIERLEIFRTQTLAQLDPIDEKKKAANAAMEELLDSTVGSDNFVIPEILISNSRAALYVYLNAALVARPVLDDSMLYAFLSNKYQENQQASAVDLIVASFDVLANAVFRNEGPRDAHLLRSFVVNKLPLLLCQLCHPEFSAASAEFCITEALSRVDTGIFPTASLMFDESRNNNPYMDSVREEFCAACALHGLIERDHVDRILGETSMSYDPSLERANRDRLVSDCLSDSGRIQNIISQLDRVDGNVGAVAHAIVEPQSLDIILLFDKVTSVLEPVCTLLDNWNYEEDQGEYQPVYEEYGAILLLVFAFTYRYNLSPLDIGIQSADSHVAKIIAKSHILRPLEDLNEQEAEHVAGWITGLFDNETGGLGDDLMSSCPPHEFYLLVAPIFQSIITAYTYGYINDESLKGGVEYLVDTFLLPSLVPAIRFLSDYIWIDEKEQKSIVKALQLLLTPSSISGEASTVLSAVKNLIAQPLEHALRTYQRQDPRNQDIEPLLRSLKENLPLSRRTGGPEHHEMVSWANNSNSGLSGAIRHTIQGLVQWSLQPGVNVMPTSYTHRQLITGLRIIGPSRLLRLIMEEIRQQSELGNASIVYDVAAALIAATDPTNEAPPGPNLLDTAGTMQATPPPQRPQGLREALKTAAEGCKRLQKHEQFLAEATVRLHRRVEMLLVVPQTQAILQTTDMPLDLGGDAMAAAAAAAAAVGADPMSVDGLDTTGLDTTGLDLGLGADMGLSGGGSDGDLFGGLDTSLDMFDGWDSMDMGVN
Length1036
PositionTail
OrganismBeauveria bassiana (White muscardine disease fungus) (Tritirachium shiotae)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Cordycipitaceae> Beauveria.
Aromaticity0.07
Grand average of hydropathy-0.114
Instability index44.67
Isoelectric point4.82
Molecular weight114456.89
Publications
PubMed=27470140

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP19256
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.29|      29|      36|     956|     991|       1
---------------------------------------------------------------------------
  956-  991 (39.14/39.16)	MPLDLGGDaMAAAAAaaaavGADPMSVDGLDTTgLD
  995- 1023 (53.14/30.77)	LDLGLGAD.MGLSGG.....GSDGDLFGGLDTS.LD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.74|      28|      37|     417|     453|       2
---------------------------------------------------------------------------
  417-  445 (47.40/44.92)	EFCITEAL......SRVDTgIFPTASLMFDES..RNN
  455-  490 (42.34/18.84)	EFCAACALhglierDHVDR.ILGETSMSYDPSleRAN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.17|      10|      15|     120|     129|       3
---------------------------------------------------------------------------
  120-  129 (18.18/11.90)	GDGEMMKKEE
  137-  146 (17.99/11.70)	GAGGVMRQDK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.90|      28|      40|      35|      74|       4
---------------------------------------------------------------------------
   38-   71 (37.83/44.72)	DFVHLVharHPlPPVLVADL.FLRPQpsNRVSLDP
  262-  290 (47.07/17.91)	NFLQTV...QP.PPLYIERLeIFRTQ..TLAQLDP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.45|      19|     154|      77|      97|       5
---------------------------------------------------------------------------
   77-   97 (28.06/18.16)	VRILaqLRYVDAPSILRVLYK
  226-  244 (32.39/15.65)	VPLL..LRLVDNHELLRIISK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.36|      15|      15|     745|     759|       7
---------------------------------------------------------------------------
  745-  759 (27.56/18.76)	QPLEHALRTYQRQDP
  762-  776 (23.81/15.12)	QDIEPLLRSLKENLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.89|      29|      40|     327|     355|       9
---------------------------------------------------------------------------
  327-  355 (47.90/29.06)	AALYVYLNAALVARPVLDDSMLYAFLSNK
  370-  398 (48.98/29.87)	ASFDVLANAVFRNEGPRDAHLLRSFVVNK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19256 with Med5 domain of Kingdom Fungi
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