<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19254

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDTVDSETNVLLVSNIASVAYRFYEPSADSKQTFFPNALGIETSLREQGRIVSFDATRRGLWYFHIRRSVGAESQGPAELGATAVVNDQFLMSTKHGSMEPSQWHKSLAPEPPTHRPNQTSSGHAAQLQLTGSQQDHEATAITEQTELRQSNGFTPKVLYESFIGALLLTICSSFCSKSEAVPLNFRTVLLPALKASETATDRWIGEQAQALGTLKCYMISTGSLILSFSVTVCPGLASLEDILSSNSNPIGNNILAAPFGVMTNEEQSPSSHSTGAPLAHTPTIQTLAQRSPSNVNSSLWKQACLAIFQLRGVPGAALRECSWVNLLVSKPKLQDTKPENGRAAHCTISIPWPGSLCFRKKAVELSATNRISDTIVVGHDETHDPLGDARGWLSSANEREERISKRHAERSAAGAKENSAVDTRLGKINAPSPVTMRRPSTTGGNAVYPTPPDAIQNLNGVTPSMDGNLSSPGHPLSVVADVDIDCEPPGEENSVHQNDDEMTEAADGKPLRSDNNLLSEAENMFEDMGGDMFGDNDITEADFSFFDEQPDEMGMDMSFDSIKGSRVPSALPINGEEPVASASINAPPSAESAVFAKPELKHARSSQPEDAPQRGRDHPAKSAKRGSSPFDPDSVFKRLRAAASQRNPRGAYGVGLNRGIKVFEKVDFDSKMPMLNKKYEHGGLFDFVPNATDTDKLEPGTLPKTDYLRRHGKTRAKQQADSRRPSIVKSTTDPDTQLLDHQLLNLDGDISDGDDSSSDSDIASNLSVKEPVSPVKSTVKQSILGDEDAASYVTTGRDQDLAEEPDEQLALELPRLSLLDGPDTPLFRYFTDPEPLSLDISLSDEDMIQVAQLVAEQAAAGSLSIFSSHSDNALSTATEEDARIEQLTSTRSALQALRDAASSFLGTMSPVGLKTLLEVQDGSLTGQGNRVQPRQVPSKDPNSEPIKPSNLYQIPCPHLEVRRADVRMSLLPTAVTFWENLGLAPSSGSKDIRAVCVCPKWTGMIDNAQVFLGRLKSTYETLKLGTFENMPLSAGLEDGVLLYGVDRISTAPDATMMGHGSALLESMETLSGAMSDLEVVDTNVVVYFMYSTSNPGTIVEACMAFQRFFESYRRTLVAKRESAKNEIVLQLVSADAISSSTSMVITPSSELVKLCMETYDRCTLFGGNMPAPAIRLEQPLPRIIDFKLSPAPSSSLARENSCIHIAYARSIDGRWVTAAWTDDRGNEQATAAYCLGHKGEPETRTMNDVAHEIWQTTVELISTWKVHYRIIMTKCGPADEGEIDFWVDLARTEMHASVTMIVMTVETNPSLQLVPAPIKMSLQPLSIYTTPVSTPQANIVSPEASAAPATPARDTTGAVATPGGESNGDADVDSVLADVMDQTWGAIVNHRLNNTVGTTSIQPALISGYLIKRTGPKAEDVPSIMEVNLVYTEASARTYEPLLREMLSYFRGLGTLARARGVVDRVTDVRPWHVAAAEKALRALYILM
Length1489
PositionKinase
OrganismBeauveria bassiana (White muscardine disease fungus) (Tritirachium shiotae)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Cordycipitaceae> Beauveria.
Aromaticity0.06
Grand average of hydropathy-0.323
Instability index47.38
Isoelectric point5.02
Molecular weight161315.37
Publications
PubMed=27470140

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP19254
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     110.69|      35|      38|     573|     609|       1
---------------------------------------------------------------------------
  573-  609 (55.96/37.51)	PING.EEPVASASINAPPSAESAVFAKpeLKHARSSQ.P
  613-  649 (54.73/30.27)	PQRGrDHPAKSAKRGSSPFDPDSVFKR..LRAAASQRnP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     417.41|     132|     144|    1135|    1278|       2
---------------------------------------------------------------------------
  278-  383 (112.46/53.04)	...................................................PLahtPTIQTLaQRSPSNvNSSLWKQ.ACLAIFQLRGVPGAALrECSWVNllvskpklqDTKPENGRAAHCTISIPWPGSLCFR.......KKAVELSATNRISDTIVVGHDET
 1135- 1278 (216.26/133.31)	AD..AISSSTSMVIT...PSSELVKLCMETYDRCTLfggnMPAPaIRLE.QPL...PRIIDF.KLSPAP.SSSLARENSCIHIAYARSIDGRWV.TAAWTD.........DRGNEQATAAYCLGHKGEPETRTMNdvaheiwQTTVELISTWKVHYRIIMTKCGP
 1279- 1362 (88.70/39.67)	ADegEIDFWVDLARTemhASVTMIVMTVETNPSLQL....VPAP.IKMSlQPL....SIYTT.PVSTPQ.ANIVSPEASAAPATPARDTTGAVA.T.....................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.90|      19|      38|     450|     468|       3
---------------------------------------------------------------------------
  450-  468 (35.86/21.54)	PTPPDAI.QNLNGVTPSMDG
  490-  509 (28.04/15.14)	PGEENSVhQNDDEMTEAADG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.58|      33|      36|     845|     880|       7
---------------------------------------------------------------------------
  847-  880 (47.60/32.37)	DmIQVAQLVAEQAAAGSL.....SIFSSHSDNALSTATE
  882-  919 (46.98/21.72)	D.ARIEQLTSTRSALQALrdaasSFLGTMSPVGLKTLLE
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19254 with Med13 domain of Kingdom Fungi
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