<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19247

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMDAFTIITRRSCARGLDQLEWMKEVKSILNIIPSSSSSSSSSSSSSSSSSSSREQATALIDLVLSTNPISVRLLTYYRAALNTLIDPSDAATHLITITPTVPLPLVRAELINQIALPLINSHPHLKCQNPSHAITLLNLLLNLINNQHLNHSPILTLTENLIKPLTHFILSYPPNCFIQSNPQAVQEAIQSITNTLDHPSTSTINNYQLPSILRHLSPSTAKQLALSSSQQPTQSPTTTTTTTTTTTTTTTTTTTTTSSSSSSASALIAYILLTPGASALASDQTTPSLILSRIISFALSDQPPHSNFILELLLAAIKLGNSHPPTPFQAPSKTDTLSDLNNNNNNNNNNNNDEDDPYLENDKMCWKALLAGGRLAELIRSAIDSDAIKSQPEVMVQLLTITHLEILSQHIITQKKSIPDVQHQPISQTDEDVHMDMDPTVPAVEYTTRHHLWFALLSSLCSNQLIIPEDIEKLEQSNSAPNHLVLGHHSDVELGLQPLYESLGIDKQKPISELAGKLQESIMTATMSFDLSTCISLTKAISSLDSLCTILIWLQPRNILGPIRTLLDDWNNIRNNNNQVINNSDNDESSSGSEFEKFGGLLGWLQGVVGRFGLMSQLGYHLGTTKGFTIHYLSNPSTAYPLSSLPSTHTTTLASWIEALYGSSGIPDDLLSNTDPRIFFTISATLFKQSFDALTSGLIDLQTFRDGLSYFEHKLLIGGCAVGVVGWLLNELTAAGSSISATSFPTALLEILQAILLSDSITSTALRLVSARSLALLRGFDHSFSRAPPDHLGPGADLNRRVQLDLGAIERRLTVQPVSEMILPTGFLAFDFGRGQAVVRWTDALRLAVQMAVDGDRERPGPDPTIALWSLLPHILKAVSVREFVQMTIAAAVEPSRSTGEDHGLVVGDDTYPARLGVRVQKAWNAATYRRVERAVGLAVDILTWMTDDIHGPSSGPLSLVLEELFQRWGARLGTTSSVEAAEVERDIVLGCLDRLESWELVTARDPHKKQQQQSASQENSNQAVASGLSDPTPLQTKDQDSAPDPPLPVITDGFRKACLESLRREKLRSLGLVIKPEPPTPPGPRLDLASESAAVSGSAAAGRDEEARDMDASGPAPAKDGESGEDASGGQEEEKGGEAEAGKEEELPAAAEQAMEVVGESDTLAEKEKKDQLQGQANEQSGDGCHESEAGEGEDKMDEGAVEAVLAGRAVGERAGGEWKRVHFRDEAGAARTGDEGEKTSRDTPPSPPLKKKKGRPADPQQQDPPSALDWIVASLAVAPVPARPPYTQLPPAAHPDLATLVRDHLAPTLPYKLVGIIPR
Length1321
PositionTail
OrganismPuccinia coronata var. avenae f. sp. avenae
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Pucciniomycotina> Pucciniomycetes> Pucciniales> Pucciniaceae> Puccinia.
Aromaticity0.05
Grand average of hydropathy-0.248
Instability index50.66
Isoelectric point5.07
Molecular weight142578.68
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP19247
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.91|      14|      15|    1206|    1219|       1
---------------------------------------------------------------------------
 1206- 1219 (23.28/12.20)	V.LAGRAVGERAGGE
 1223- 1237 (19.63/ 9.25)	VhFRDEAGAARTGDE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.29|      13|      15|    1097|    1110|       2
---------------------------------------------------------------------------
 1097- 1109 (23.21/ 8.73)	SGSAAAGRDEEAR
 1124- 1136 (22.08/ 7.73)	SGEDASGGQEEEK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.94|      13|      15|     137|     151|       3
---------------------------------------------------------------------------
  137-  151 (18.51/16.99)	LNLLLNLInnQHLNH
  155-  167 (22.43/12.70)	LTLTENLI..KPLTH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     280.87|      80|      84|     353|     434|       4
---------------------------------------------------------------------------
  279-  349 (84.15/53.80)	..................ALASDQTTPSLILSRIISFALSDQPphsNFILELL.LAAIKLGNS......HPPTpfQAPSKTDTLSDLNNNNNNNNN
  353-  434 (124.55/94.33)	DEDDP...YLENDKMcWKALLAGGRLAELIRSAIDSDAIKSQP...EVMVQLLtITHLEILSQ......HIIT..QKKSIPDVQHQPISQTDEDVH
  438-  499 (72.17/45.18)	DPTVPaveYTTRHHL.WFALLSSLCSNQLI...IPED....................IEKLEQsnsapnHLVL..GHHSDVELGLQPL........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.34|      13|      15|    1176|    1188|       5
---------------------------------------------------------------------------
 1176- 1188 (24.29/17.35)	GQANEQSGDGCHE
 1192- 1204 (22.05/15.00)	GEGEDKMDEGAVE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.77|      15|      15|     544|     558|       6
---------------------------------------------------------------------------
  544-  558 (28.00/14.35)	LDSLCTIL.IWLQPRN
  560-  575 (22.77/10.44)	LGPIRTLLdDWNNIRN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.44|      18|     216|      34|      68|       7
---------------------------------------------------------------------------
   47-   68 (22.79/37.77)	SSSSSSreqATALIDLVLSTnP
  258-  275 (32.65/ 9.82)	SSSSSS...ASALIAYILLT.P
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.83|      15|      17|     732|     748|       8
---------------------------------------------------------------------------
  732-  748 (20.10/19.79)	L...TAAGSSISATSfpTAL
  749-  766 (19.73/10.12)	LeilQAILLSDSITS..TAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.16|      13|      15|     602|     614|       9
---------------------------------------------------------------------------
  602-  614 (24.35/14.42)	LGWLQGVVGRFGL
  618-  630 (23.81/13.94)	LGYHLGTTKGFTI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     187.00|      65|      70|     781|     850|      10
---------------------------------------------------------------------------
  767-  816 (49.84/26.47)	.......................RLVSARSLALLrgfDHSFSRAPPDhlgPGADLNRRVQLDLGAIERRLTVQ
  817-  886 (103.03/55.49)	PVSEMILPTGFLAFDfgRGQAVVRWTDALRLAVQmavDGDRERPGPD...PTIALWSLLPHILKAVSVREFVQ
  888-  919 (34.13/11.29)	TIAAAVEPSRSTGED..HGLVVGDDTYPARLGVR.......................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.29|      11|      16|     973|     983|      13
---------------------------------------------------------------------------
  973-  983 (17.18/ 8.06)	LGTTSSVEAAE
  990- 1000 (21.10/11.50)	LGCLDRLESWE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.88|      10|      30|    1044|    1056|      15
---------------------------------------------------------------------------
 1044- 1056 (17.88/15.43)	PDPPLPvitDGFR
 1077- 1086 (24.00/12.10)	PEPPTP...PGPR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.93|      26|      47|     178|     203|      16
---------------------------------------------------------------------------
  178-  203 (43.24/23.13)	IQSNPQAVQEAIQSITNTLDHPSTST
  226-  251 (42.69/22.74)	LSSSQQPTQSPTTTTTTTTTTTTTTT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.54|      18|      92|     111|     133|      18
---------------------------------------------------------------------------
  111-  133 (28.04/27.68)	INQIALPLInshphLKCQNPSHA
  204-  221 (33.51/18.51)	INNYQLPSI.....LRHLSPSTA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.85|      18|    1208|      87|     106|      19
---------------------------------------------------------------------------
   87-  106 (24.79/24.50)	PsDAAThLI..TITPTVPLPLV
 1297- 1316 (29.06/16.93)	P.DLAT.LVrdHLAPTLPYKLV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19247 with Med5 domain of Kingdom Fungi
Unable to open file!