<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19240

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAGGPHVVRFADSQVHWVVFEVTPFCCGIGARLSVGGGPGLDRVEVRQRGRGAYNQLLLLPTTFCFDFAGRWRTEHTDAHPRKDAQHGMMTSLEKSKQEQYMANKQEHMANTQQYSYRSASQKTPSGFVNTSPASSSSSSSAHQPTKKIHAECSTQRLTPFDQETINQIDRVELQRDWGPHLVPLQFVIQRTIAQVFCEMQTLTQGCANAEDYDRKKHIIDFVVHARRQFIKLLVLVKWSTHSGSVHKIMSIVGFLQRQNNQFKRNVNILKASKENFHSARMRNYDLPTALQVLTNGYPTLPGRLIDQFDSKPKLSDSQVIKIMQDLNELIRYRLASREIIPKDFRSYQIYDGRVAFRIDRMFECSLTLGGGELDSQWYLLHVEFLFKVTGPRGNDFMCIPQGPIKDQIIECGNRVMAPSTLSPESDPDPKPPERPIMKVFAYLRDLCLNYQLEALHYQASQLGRSAWATHTRLLISTDRKNLTIMYWLNARPVSIPVTRPGQQPPKNLPQPTPQGTLTIRRQIERHSPSRTRVLGFLSGYPLKDKILSNEQDDDFGASSTERLQVVWRPIEVTTRAGSLEQEALKDLQIRQGDEVVFTKTEVGLVELELTINDLCLESIIQRAVRVHTDSALRRAFSDLTRLERPAGGPSTYAVPYFASVRLIACENINSSERFAKSIEVVLHARHAVEVSIDQFSGRFRLQSIAHPSRTQKDDNESAHSLGVGCFSGYNPLRLSQSANKININPSGLRDVLVRLKSDILLDQIEFKARLLGIRTTRNLPIQLQHLSLPSYLSSPSTIPQHIFQLTLYCRLSNFPHHYLLIMVTENGIRCALIIVNQNRDDQPPLHLGGTTCWNVDSVSAVAVPTFADDLDEDGGVLDQFTLSRTQLEYVYHFCLVQATLNQLKAPLRKSEISYEQFLPMTAEIIKKQYQNYRSHRSTLPSNPSSPSIKLPVLHLSYEVMGLLLIPLPGLLKPSLLYDHHSHRGVFRENLAVQVFPHPGSHFGVRLEVRLNFNPEKLRPEELEKIFKSKEENLNSKIISSYLSRPSKSKPSASSFLLPSLRYLKQPRKNDDDDDDDDDDDEDEEPLSRRIQTTLLKPASPLANTTEEHEKKETEDDPDAELIGPGEWSIDAQSHQFVMRFQNFTEQVDQIYKLSLQKFFNLIQSSASSDP
Length1171
PositionTail
OrganismPuccinia coronata var. avenae f. sp. avenae
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Pucciniomycotina> Pucciniomycetes> Pucciniales> Pucciniaceae> Puccinia.
Aromaticity0.08
Grand average of hydropathy-0.449
Instability index46.40
Isoelectric point8.15
Molecular weight133084.69
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP19240
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     450.65|     147|     165|     444|     608|       1
---------------------------------------------------------------------------
  444-  602 (226.96/160.02)	LRDLCLNYQLE.ALHYQASQLGRSAWATHTRL.LISTDRKNLTIMYWLNARPVSIPVTRPGQQPPKNLpqptpQGTLTIRR....QIERHSpSRTRVLGFlsGYPLKDKILSNEQDDDFGASSTERlqvvWRPIEVTTRAG..SLEQEALKDLQIRQGDEVVFTKTE
  612-  766 (223.70/121.97)	INDLCLESIIQrAVRVHTDSALRRAFSDLTRLeRPAGGPSTYAVPYFASVRLIACENINSSERFAKSI.....EVVLHARHavevSIDQFS.GRFRLQSI..AHPSRTQKDDNESAHSLGVGCFSG....YNPLRLSQSANkiNINPSGLRDVLVRLKSDILLDQIE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     276.59|      92|     165|     103|     213|       2
---------------------------------------------------------------------------
  103-  213 (140.64/124.54)	ANKQE.HMANTQQYSYRSASQKTPSGFvNTSPA............SSSSSSSAHQPTKK.IHAECSTQRLTPFDQETINQID.RVelqrdwgphlvplQFVIQRtiaqVF.CEMqTLTQGCANAEDY
  272-  379 (135.95/82.01)	ASKENfHSARMRNYDLPTALQVLTNGY.PTLPGrlidqfdskpklSDSQVIKIMQDLNElIRYRLASREIIPKDFRSYQIYDgRV.............AFRIDR....MFeCSL.TLGGGELDSQWY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     111.11|      30|     268|     838|     867|       3
---------------------------------------------------------------------------
  838-  867 (55.93/39.67)	QNRDDQPPLHLGGTTCWNVDSVSAVAVPTF
 1112- 1141 (55.18/39.02)	KETEDDPDAELIGPGEWSIDAQSHQFVMRF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.58|      19|     268|     775|     796|       4
---------------------------------------------------------------------------
  775-  793 (33.83/22.05)	RTTRNLPIQLQHLSLPSYL
  959-  977 (31.75/11.87)	EVMGLLLIPLPGLLKPSLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     182.31|      58|     106|     893|     954|       5
---------------------------------------------------------------------------
  893-  954 (93.05/75.38)	HFCL.VQATLNQLKAPLRKSEIsyEQFLPMTAE.IIKKQYQNYRSHRStlPSNPSSPSIKLPVL
 1002- 1061 (89.26/59.53)	HFGVrLEVRLNFNPEKLRPEEL..EKIFKSKEEnLNSKIISSYLSRPS..KSKPSASSFLLPSL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19240 with Med14 domain of Kingdom Fungi
Unable to open file!