<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19238

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMSDSPNHQRNNNNNNNNNNNNNNNNNNNRFFQQQQQQQQQQQQYHYHHLQQQYLYQQQLLHYQHLPPYQSSSASPRQSNPYPQPLIHHRQLPQKSTQSAEPSIARPANTHSLSSPSFSLPPPPIQPPTRHHHQHHQHQHHQHSHHQYQLYQQQQQQQQQQQQQQQQQQQQQQQHQHHQQHKFDHRPNHPNHHRRDSRNYHRQSSVRANLTLPHPPKPYKSDRSATIPIIPSPTASTSQTHHHPPSCSKANNPNTIPIPTTPIHQLHSHSNSTLQSSLALDEQLGLAGPQSAGYFSPSHIEFNPWHGCSPCKWKVPLLQSGLPIHPQPNKRNTLLSIDEDVDEIHYSASHVQEEEWKIRWAKLLTSLPKEQQPTHTSSSHQTSSSPSGLDELKIEIAHQLHAHKLHFVFDSEGDEENELCLIVWVYEIPGQLGPKTSPTENTLPDHAKSSNHQGPPPLIDPILMTYQSFEHHSQISSNSPHEIKACQAVMSYGVLSYSQLFPDIFSRSATANSKPLLPHLSHPAKNRTANDFLVEDSSQTNIIPAYANLLRALNQHVITLAVRSPDSTPFPGACPTRWIRWGPDRLLSIPREESLEYLYRNLNSDSARLLAAILATPSALLVELNCWLSSRVAMCQPSFTAKRLAPMPTLPQHHIPPGFPLILAPFPNLRAHYVRMFGRFNHHSLAKQKPTRSSQSPADRSSWLSNPSIPNASWISQQKRTCRAELKHFEKLKQTWRTAAPFMESYPAESHTTPTTSTGQRNLESWVVCKITTSEVTHLENEQSPEIELVWPVDHCLLDLETWIANNERAPTIPPTTEADQPVKLAAPLSGTRLPRVRLANALMLSAHESTDKLAEEAGSYIDWVAQERELQRRAAATAGKEKALEKTESPPSMSVGRAAGLGLGRGRGSGFPSPRFQRHASTSTTHASPGPSHLLTPRLSKKRLRDESDDRLSNQPSLVASAFPSSITSFDAGITPQHATASNQGDPSVVDVTSNGLIEDSAMDILNDSSGGNATLLPEPLVSQPPVSSISSSARDEAFPHHHDHHQSSSAASALSSQLVTTSSQFVSAQQGSGSGSTASTISYNTNLFEQPTPGSVSISGMTPGRLNGLTPDATHNNHLLNQATLHSSPINPNLHSTAVEPSQVDRLVVSEHALRTLSLMSSSESAPLTTTDYRALEPLGYESVRFSDSHTVIDDHYTRRGGKYALPPSPRSFVGPDDEQDDMMMDIVPQELLRTARGPLLVHVSKKLMRAIDPRAKVARTLFNNNNSSSSSKMRTTCNDLPQQPPFTRVEPSMSIAPAQGPGALADSPATPRSWVPIGSPSGTTDSSICSDEEDELDGNGFFRSTGCDRESRSSTTSSCSSDDERMMAVDGEYQNGIATKIERIESCLKNVLQANFRSTFLRVHPHSPTEQNCLLSQKPPIDNLPPRPQHIPSSLRKKLKNWVSQLASQLEHDPNLDALLATVLSSSSSPPSSPKGFPSVPTDIRKAEEAVVLDLASLPMIHGFDYYRARLDDEYEIQEERIGSDPKKSEEDKKGGKQSEGKKKAGEGEAGTDGDGDGGDQRPYLIKKLSKLPTSVVVKMNEGKLRIAFSLISHLFKFWIKLGLEPVPGSRHLVLSVLFPSPPSAFQKATQTQDSMMVDSPTQDPRENSKTHLPSVHHWLVELAHMYKSCRLGELSIGKIQDSKYRPMELKKEIEGMIGEMKCGNGARHACLIVVDRLEEMQSLAIGEDAIVGLDGRPVTRVLVSRDQLLDDRPASLVSFALRLYDSMKIFVHRFQAPRLSFEPSPCTGPGSMEACSDSEGSSISGEKAGRGAAAGGDDHTGSGPRVPGECTASTRARSADCKLLSGHAFFLSGIQKPTQLNIRWPPSGIDVGARHRMLHVGYLVGPQRAWVLVSLVDELGQQHQLVLKFPRPSPSHNLDPDYHHHHHHHQLEIQIVTAVWDVLRKTILATNIEWRIVITKLGRLEPSEYEAWCELLSQILLGSEMAFHVTLASVMLGEIPVLRRGSLGDLLDGGQVPPLSQGAAGTGEEEGAELEMGEVEGTEEGEEQGVGGGRTVGGGGGPTTAAAATAAATAGSSAMMMMMMPGDEGAGTDRIGAGPAEPFWVAHESSIRPHSTYAPGASPFGRPRSVNGTVVHSLSTSYVYHQGGCVGPVGGCSGVLMNATSAGAGRFRLDVLGTAATPGSVYQGNLFQLREEIVLSLVQLAKLHALRAGRHPTAASSEPQLFLPAHLASLLSLGSALANHLEPICASLIHPIPPPPPPHPDDPAAPVDQPK
Length2278
PositionKinase
OrganismPuccinia coronata var. avenae f. sp. avenae
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Pucciniomycotina> Pucciniomycetes> Pucciniales> Pucciniaceae> Puccinia.
Aromaticity0.05
Grand average of hydropathy-0.582
Instability index58.75
Isoelectric point6.59
Molecular weight249781.55
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
chromatin binding	GO:0003682	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
cell cycle	GO:0007049	IEA:UniProtKB-KW
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP19238
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     147.27|      21|      94|      33|      58|       1
---------------------------------------------------------------------------
   33-   53 (47.37/18.37)	QQQQ..........QQQQQQQYHYHHLQQQY
  130-  148 (35.69/ 8.14)	HHHQ..........HHQHQHHQHSHH.QYQ.
  164-  182 (36.31/13.94)	.QQQ..........QQQQQQQ.HQHHQQHKF
 1904- 1933 (27.91/ 6.15)	QQHQlvlkfprpspSHNLDPDYHHHHHHHQ.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     491.94|     119|     126|     371|     490|       2
---------------------------------------------------------------------------
  233-  372 (148.81/71.48)	TaSTSQTHHhppSCSKANNPNTIPIPTTpiHQLHSH.......SNSTL.....QSSL.AL....DEQLGLAGPQSagyfSPSHIEFnPWHGCSPCKWKVPLLQSGLPIHPQPNkrntllsidedvdEI.HYSASHVQEEEWKIRWAKLLtslpkeqQ..P
  373-  501 (191.19/97.97)	T.HTSSSHQ...TSSSPSGLDELKIEIA..HQLHAHKLhFVFDSEGDE.....ENEL.CLIVWVYEIPGQLGPKT....SPTENTL.PDHAKSSNHQGPPPLIDPILMTYQSF.............EH.HSQISSNSPHEIKACQAVMSygvlsysQlfP
  502-  617 (151.94/73.16)	D.IFSRSAT...ANSKPL.LPHLS.HPA..KNRTANDF.LVEDSSQTNiipayANLLrALNQHVITLAVR.SPDS....TPFPGAC.PTRW...IRWGPDRLLS..IPREESL.............EYlYRNLNSDSARLLAAILATPS...........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     604.82|     158|    1243|     814|     978|       3
---------------------------------------------------------------------------
  636-  774 (178.17/88.06)	.....PSFTAKRLAPMPTLPQHHIPpgfPLIL.APFPNlrahYVRMF..GRFNHH..................................slakqkPTRSSQSPA.DRSSWLSNPSIP.....NASWISQQKRTCR.AE.....LKHFEKLKQTWRTAAPFM..ESYPAESHTTPTTSTG.....................QRNlESWVVCKITT.SE
  776-  931 (223.00/120.42)	THLENEQSPEIELVWPVDHCLLDLE...TWIAnNERAP....TI..................................................pPTTEADQPV.KLAAPLSGTRLPRVRLANALMLSAHESTDKLAEEAGSYIDWVAQERELQRRAAATAGKEKALEKTESPPSMSVGraaglGLGRGRGSGF.PSPRFQRH.ASTSTTHASP.GP
  932- 1133 (203.65/106.40)	SHLLTPRLSKKRLRDESDDRLSNQP...SLVA.SAFPS....SITSFdaGITPQHatasnqgdpsvvdvtsngliedsamdilndssggnatllpEPLVSQPPVsSISSSARDEAFPHHHDHHQSSSAASALSSQLVTTSSQFVS..AQQGSGSGSTASTISYNTNLFEQPTPGSVSIS.....GMTPGRLNGLtPDATHNNHlLNQATLHSSPiNP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.48|      12|      15|    2000|    2011|       4
---------------------------------------------------------------------------
 2000- 2011 (21.82/11.80)	GEIPVLRRGSLG
 2017- 2028 (22.66/12.60)	GQVPPLSQGAAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     123.45|      29|    1244|     185|     215|       5
---------------------------------------------------------------------------
   61-   85 (32.51/ 9.98)	.....HYQHlpPYQSS..S..ASPRQSN.....PYPQPL
   89-  123 (37.61/12.71)	RqlPQKSTQ..SAEPSiaRpaNTHSLSS..PSFSLPPPP
  185-  215 (53.33/25.54)	R..PNHPNH..HRRDS..R..NYHRQSSvrANLTLPHPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.03|      11|    1244|      18|      29|       6
---------------------------------------------------------------------------
    3-   13 (21.38/ 9.39)	DSPNHQRNNNN
   19-   29 (20.65/ 7.92)	NNNNNNNNNNR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     286.50|      92|     297|    1514|    1625|       7
---------------------------------------------------------------------------
 1520- 1619 (138.88/91.35)	QEERIGSDPKK.....SEE...DKKGGKQSeGkKKAGEG.EAGTDGDGDGGDQRPYLIKKLSKlPTSVVVKMNEGKlriAFSL.....ISHLFKFWIKLGLEpvPGSRHLVLSV
 1778- 1883 (147.62/64.69)	QAPRLSFEPSPctgpgSMEacsDSEGSSIS.G.EKAGRGaAAGGDDHTGSGPRVPGECTASTR.ARSADCKLLSGH...AFFLsgiqkPTQLNIRWPPSGID..VGARHRMLHV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     116.91|      40|     297|    1152|    1195|       8
---------------------------------------------------------------------------
 1152- 1195 (58.30/45.39)	EH..ALRTL..SLMSSSESAPLTTTDYRALePlgyESVRFSDSHTVID
 1453- 1496 (58.61/32.97)	EHdpNLDALlaTVLSSSSSPPSSPKGFPSV.P...TDIRKAEEAVVLD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.87|      23|      93|    2055|    2078|      10
---------------------------------------------------------------------------
 2055- 2078 (36.33/28.46)	GGrTVGGGGGPTTAAAATAAATAG
 2150- 2172 (44.54/30.16)	GG.CVGPVGGCSGVLMNATSAGAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.62|      11|      15|    1324|    1335|      13
---------------------------------------------------------------------------
 1324- 1335 (16.32/13.87)	GTTDSSICsDEE
 1342- 1352 (22.30/13.82)	GFFRSTGC.DRE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.87|      26|     411|    1207|    1232|      14
---------------------------------------------------------------------------
 1207- 1232 (51.92/25.90)	LPPSPRS.FVGPDDEQDDMMMDIVPQE
 1620- 1646 (45.95/22.06)	LFPSPPSaFQKATQTQDSMMVDSPTQD
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19238 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DGGQVPPLSQGAAGTGEEEGAELEMGEVEGTEEGEEQGVGGGRTVGGGGGPTTAAAATAA
2) IQEERIGSDPKKSEEDKKGGKQSEGKKKAGEGEAGTDGDGDGGDQRPYL
3) MSDSPNHQRNNNNNNNNNNNNNNNNNNNRFFQQQQQQQQQQQQYHYHHLQQQYLYQQQLLHYQHLPPYQSSSASPRQSNPYPQPLIHHRQLPQKSTQSAEPSIARPANTHSLSSPSFSLPPPPIQPPTRHHHQHHQHQHHQHSHHQYQLYQQQQQQQQQQQQQQQQQQQQQQQHQHHQQHKFDHRPNHPNHHRRDSRNYHRQSSVRANLTLPHPPKPYKSDRSATIPIIPSPTASTSQTHHHPPSCSKANNPNTIPIPTTPIHQLHSHSNSTLQSSLALDEQ
4) PCTGPGSMEACSDSEGSSISGEKAGRGAAAGGDDHTGSGPRVPGECTA
5) QRRAAATAGKEKALEKTESPPSMSVGRAAGLGLGRGRGSGFPSPRFQRHASTSTTHASPGPSHLLTPRLSKKRLRDESDDRLSNQPSLVA
6) SAMMMMMMPGDEGAGTDRIGAGPAEPFWVAHESSIR
7) SFDAGITPQHATASNQGDPSVVDVTSNGLIEDSAMDILNDSSGGNATLLPEPLVSQPPVSSISSSARDEAFPHHHDHHQSSSAASAL
8) TSSQFVSAQQGSGSGSTASTISYNTNLFEQPTPGSVSISGMTPGRLNGLTPDATHNNHLLNQATLHSSPINPNLHSTAVEPSQVDRL
9) VARTLFNNNNSSSSSKMRTTCNDLPQQPPFTRVEPSMSIAPAQGPGALADSPATPRSWVPIGSPSGTTDSSICSDEEDE
10) YTRRGGKYALPPSPRSFVGPDDEQDDMMMDIVPQ
2015
1519
1
1788
871
2080
969
1062
1259
1198
2074
1567
282
1835
960
2115
1055
1148
1337
1231










Molecular Recognition Features






MoRF SequenceStartStop




NANANA