<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19225

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAGGPHVVRFADSHARLSVGGGPGLDRVEVRQRGRGAYNQLLLLPTTFCFDFAGRWRTEHTDAHPRKDAQHGMMTSLEKSKQEQYMANKQEHMANTQQYSYRSASQKTPSGFVNTSPASSSSSSSAHQPTKKIHAECSTQRLTPFDQETINQIDRVELQRDWGPHLVPLQFVIQRTIAQVFCEMQTLTQGCANAEDYDRKKHIIDFVVHARRQFIKLLVLVKWSTHSGSVHKIMSIVGFLQRQNNQFKRNVNILKASKENFHSARMRNYDLPTALQVLTNGYPTLPGRLIDQFDSKPKLSDSQVIKIMQDLNELIRYRLASREIIPKDFRSYQIYDGRVAFRIDRMFECSLTLGGGELDSQWYLLHVEFLFKVTGPRGNDFMCIPQGPIKDQIIECGNRVMAPSTLSPESDPDPKPPERPIMKVFAYLRDLCLNYQLEALHYQASQLGRSAWATHTRLLISTDRKNLTIMYWLNARPVSIPVTRPGQQPPKNLPQPTPQGTLTIRRQIERHSPSRTRVLGFLSGYPLKDKILSNEQDDDFGASSTERLQVVWRPIEVTTRAGSLEQEALKDLQIRQGDEVVFTKTEVGLVELELTINDLCLESIIQRAVRVHTDSTLRRAFSDLTRLERPAGGPSTYAVPYFASVRLIACENINSSERFAKSIEVVLHARHAVEVSIDQFSGRFRLQSIAHPSRTQKDDNESAHSLGVGCFSGYNPLRLSQSANKININPSGLRDVLVRLKSDILLDQIEFKARLLGIRTTRNLPIQLQHLSLPSYLSSPSTIPQHIFQLTLYCRLSNFPHHYLLIMVTENGIRCALIIVNQNRDDQPPLHLGGTTCWNVDLVSAVAVPTFADDLDEDGGVLDQFTLSRTQLEYVYHFCLVQATLNQLKAPLRKSEISYEQFLPMTAEIIKKQYQNYRSHRSTLPSNPSSPSIKLPVLHLSYEVMGLLLIPLPGLLKPSLLYDHHSHRGVFRENLAVQVFPHPGSHFGVRLEVRLNFNPEKLRPEELEKIFKSKEENLNSKIISSYLSRPSKSKPSASSFLLPSLRYLKQPRKNDDDDDDDDDDDEDEEPLSRRIQTTLLKPASPLANTTEEHEKKETEDDPDAELIGPGEWSIDAQSHQFVMRFQNFTEQVDQIYKLSLQKFFNLIQSSASSDP
Length1155
PositionTail
OrganismPuccinia coronata var. avenae f. sp. avenae
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Pucciniomycotina> Pucciniomycetes> Pucciniales> Pucciniaceae> Puccinia.
Aromaticity0.08
Grand average of hydropathy-0.472
Instability index46.79
Isoelectric point8.31
Molecular weight131374.71
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP19225
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     370.16|     123|     165|      55|     215|       1
---------------------------------------------------------------------------
   55-  197 (181.59/152.51)	RWRTEHTDAH.........PRKDAQHGMMTSLEKSKQEQYmankqeHMANTQQYSYRSASQKTPSGFvNTSPASSSSSSSAhQPtkKIhaecSTQRLTPFDQEtINQIDRVEL.QRDWGPH.LVPLQ.......FVIQRtiaqVF.CEMqTLTQGCANAEDY
  222-  363 (188.57/132.02)	KWSTHSGSVHkimsivgflQRQNNQFKRNVNILKASKENF......HSARMRNYDLPTALQVLTNGY.PTLPGRLIDQFDS.KP..KL....SDSQVIKIMQD.LNELIRYRLaSREIIPKdFRSYQiydgrvaFRIDR....MFeCSL.TLGGGELDSQWY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     199.98|      68|     268|     706|     780|       2
---------------------------------------------------------------------------
  706-  780 (99.29/84.36)	LGVGCF...SGYNPLRLsqsANKININPSGLR....DVLVRLKSDILLDQIeFKARLlgIRTTRNLPIQLQHLsLPS..YLSSP
  975- 1051 (100.69/63.42)	LAVQVFphpGSHFGVRL...EVRLNFNPEKLRpeelEKIFKSKEENLNSKI.ISSYL..SRPSKSKPSASSFL.LPSlrYLKQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     102.77|      31|     165|     428|     458|       3
---------------------------------------------------------------------------
  428-  458 (55.34/34.62)	LRDLCLNYQLE.ALHYQASQLGRSAWATHTRL
  596-  627 (47.43/28.67)	INDLCLESIIQrAVRVHTDSTLRRAFSDLTRL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     110.83|      30|     269|     822|     851|       5
---------------------------------------------------------------------------
  822-  851 (55.70/32.14)	QNRDDQPPLHLGGTTCWNVDLVSAVAVPTF
 1096- 1125 (55.12/31.74)	KETEDDPDAELIGPGEWSIDAQSHQFVMRF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.50|      17|     213|     853|     869|      10
---------------------------------------------------------------------------
  853-  869 (30.63/18.18)	DDLDEDGGVLDQFTLSR
 1057- 1073 (31.87/19.21)	DDDDDDDDDEDEEPLSR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19225 with Med14 domain of Kingdom Fungi
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