<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19224

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMSDSPNHQRNNNNNNNNNNNNNNNNNNNNRFFQQQQQQQQQYHYHHLQQQYLYQQQLLHYQHLPPYQSSSASPRQSNPYPQPLIHHRQLPQKSTQSAEPSIARPANTHSLSSPSFSLPPPPIQPPTRHHHQHHQHQHHQHSHHQYQLYQQQQQQQQQQQQQQQQQQQQQQQQQQQQHQHQHHQQHKFDHRPNHPNHHRRDSRNYHRQSSVRANLTLPHPPKPYKSDRSATIPIIPSPTASTSQTHHHPPSCSKANNPNTIPIPTTPIHQLHSHSNSTLQSSLALDEQLGLAGPQSAGYFSPSHIEFNPWHGCSPCKWKVPLLQSGLPIHPQPNKRNTLLSIDEDVDEIHYSASHVQEEEWKIRWAKLLLSLPKEQQPTHTSSSHQTSSSPSGLDELKIEIAHQLHAHKLHFVFDSEGNEENELCLIVWVYEIPGQLGPKTSPTENTLPDHAKSSNHQGPPPLIDPILMTYQSFEHHSQISSNSPHEIKACQAVMSYGVLSYSQLFPDIFSRSATANSKPLLPHLSHPAKNRTANDFLVEDSSQTNIIPAYANLLRALNQHVITLAVRSPDSTPFPGACPTRWIRWGPDHLLSIPREESLEYLYRNLNSDSARLLAAILATPSALLVELNCWLSSRVAMCQPSFTAKRLAPMPTLPQHHIPPGFPLILAPFPNLRAHYVRMFGRFNHHSLAKQKPTRSSQSPADRSSWLSNPSIPNASWISQQKRTCRAELKHFEKLKQTWRTAAPFMESYPAESHTTPTTSTGQRNLESWVVCKITTSEVTHLENEQSPEIELVWPVDHCLLDLETWIANNERAPTIPPTTEADQPVKLAAPLSGTRLPRVRLANALMLSAHESTDKLAEEAGSYIDWVAQERELQRRAAATAGKEKALEKTESPPSMSVGRAAGLGLGRGRGSGFPSPRFQRHASTSTTHASPGPSHLLTPRLSKKRLRDESDDRLSNQPSLVASAFPSSITSFDAGITPQHATASNQGDPSVVDVTSNGLIEDSAMDILNDSSGGNATLLPEPLVSQPPVSSISSSARDEAFPHHHDHHQSSSAASALSSQLVTTSSQFPTPGSVSISGMTPGRLNGLTPDATHNNHLLNQATLHSSPINPNLHSTAVEPSQVDRLVVSEHALRTLSLMSSSESAPLTTTDYRALEPLGYESVRFSDSHTVIDDHYTRRGGKYALPPSPRSFVGPDDEQDDMMMDIVPQELLRTARGPLLVHVSKKLMRAIDPRAKVARTLFNNNNSSSSSKMRTTCNDLPQQPPFTRVEPSMSIAPAQGPGALADSPATPRSWVPIGSPSGTTDSSICSDEEDELDGNGFFRSTGCDRESRSSTTSSCSSDDERMMAVDGEYQNGIATKIERIESCLKNVLQANFRSTFLRVHPHSPTEQNCLPSQKPPIDNLPPRPKHIPSSLRKKLKNWVSQLASQLEHDPNLDALLATVLSSSSSPPSSPKGFPSVPTDIRKAEEAVVLDLASLPMIHGFDYYRARLDDEYEIQEERIGSDPKKSEEDKKGGKQSEGKKKAGEGEAGTDGDGDGGDQRPYLIKKLSKLPTSVVVKMNEGKLRIAFSLISHLFKFWIKLGLEPVPGSRHLVLSVLFPSPPSAFQKATQTQDSMMVDSPTQDPRENSKTHLPSVHHWLVELAHMYKSCRLGELSIGKIQDSKYRPMELKKEIEGMIGEMKCGNGARHACLIVVDRLEEMQSLAIGEDAIVGLDGRPVTRVLVSRDQLLDDRPASLVSFALRLYDSMKIFVHRFQAPRLSFEPSPCTGPGSMEACSDSEGSSISGEKAGRGAAAGGDDHTGSGPRVPGECTASTRARSADCKLLSGHAFFLSGIQKPTQLNIRWPPSGIDVGARHRMLHVGYLVGPQRAWVLVSLVDELGQQHQLVLKFPRPSPSHNLDPDYHHHHHHHQLEIQIVTAVWDVFRKTILATNIEWRIVITKLGRLEPSEYEAWCELLSQILLGSEMAFHVTLASVMLGEIPVLRRGPLGDLLDGGQVPPLSQGAAGTGEEEGAELEMGEVEGTEEGEEQGVGGGRTVGGGGGPTTAAAATAAATAGSSAMMMMMMPGDDEGAGTDRIGAGPAEPFWVAHESSIRPHSTYAPGASSFGRPRSVNGTVVHSLSTSYVYHQGGCVGPVGGCSGVLMNATSAGAGRFRLDVLGTAATPGSVYQGNLFQLREEIVLSLVQLAKLHALRAGRHPTAASSEPQLFLPAHLASLLSLGSALANHLEPICASLIHPIPPPPPPHPDDPAAPVDQPK
Length2259
PositionKinase
OrganismPuccinia coronata var. avenae f. sp. avenae
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Pucciniomycotina> Pucciniomycetes> Pucciniales> Pucciniaceae> Puccinia.
Aromaticity0.05
Grand average of hydropathy-0.591
Instability index59.07
Isoelectric point6.62
Molecular weight248025.72
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
chromatin binding	GO:0003682	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
cell cycle	GO:0007049	IEA:UniProtKB-KW
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP19224
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     116.08|      15|      15|     149|     163|       1
---------------------------------------------------------------------------
   33-   47 (31.57/13.21)	QQQQQQQQQYHYHHL
  123-  135 (21.41/ 6.50)	..QPPTRHHHQHHQH
  149-  163 (29.53/11.86)	QQQQQQQQQQQQQQQ
  165-  179 (33.58/14.53)	QQQQQQQQQQQQHQH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     561.88|     190|     270|    1483|    1748|       2
---------------------------------------------------------------------------
 1483- 1721 (270.29/244.01)	IHGFdyyrarlddeyeiQEERIGSDPKK.....SEE...DKKGGKQSeGkKKAGEG.EAGTDGDGDGGDQRPYLIKKLSKlPTSVVVKMNEGKlriAFSL.....ISHLFKFWIKLGLEpvPGSRHLVLSVLFPSPPsafQKA..........TQtQDSMMVDSPTQDPREN..SKTHLPSVHHWLvelahmykscrlgELSI..........................GKIQDSKYRPM.ELKKEIegmigemKCGN.GARHACLIVVdRLEEMQSLAIGEdaiVG..LDGRPV
 1754- 1999 (291.59/137.97)	VHRF.............QAPRLSFEPSPctgpgSMEacsDSEGSSIS.G.EKAGRGaAAGGDDHTGSGPRVPGECTASTR.ARSADCKLLSGH...AFFLsgiqkPTQLNIRWPPSGID..VGARHRMLHVGYLVGP...QRAwvlvslvdelGQ.QHQLVLKFPRPSPSHNldPDYHHHHHHHQL.............EIQIvtavwdvfrktilatniewrivitklGRLEPSEYEAWcELLSQI.......LLGSeMAFHVTLASV.MLGEIPVLRRGP...LGdlLDGGQV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.69|      19|      51|     914|     932|       3
---------------------------------------------------------------------------
  914-  932 (38.10/21.55)	SGFPSPRFQRHASTSTTHA
  966-  984 (33.59/17.96)	SAFPSSITSFDAGITPQHA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      88.42|      17|      39|      64|      80|       4
---------------------------------------------------------------------------
   64-   80 (30.44/11.78)	PPYQSSSASPRQSNPYP
  104-  120 (32.88/13.47)	PANTHSLSSPSFSLPPP
  375-  391 (25.10/ 8.08)	QQPTHTSSSHQTSSSPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     135.83|      33|     132|    1257|    1297|       5
---------------------------------------------------------------------------
  639-  671 (34.07/ 9.27)	C.....QPSFTakRLAP.MPTLPQHhiPPGfplILAPFP.......
 1259- 1297 (55.83/42.11)	CndlpQQPPFT..RVEPSMSIAPAQ..GPG...ALADSPatPRSWV
 1399- 1425 (45.93/18.79)	.....QKPPID..NLPPR....PKH..IPS...SLRKK...LKNWV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.55|      18|      51|    1324|    1341|       6
---------------------------------------------------------------------------
 1324- 1341 (33.73/20.92)	FRSTGCDRESRSSTTSSC
 1378- 1395 (35.83/22.78)	FRSTFLRVHPHSPTEQNC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     120.40|      37|     132|     545|     583|       7
---------------------------------------------------------------------------
  545-  583 (63.83/38.49)	NIIPAYANLLRALNQHviTLAVRSP........DSTPF...PGACPTRWI
  672-  719 (56.57/28.62)	NLRAHYVRMFGRFNHH..SLAKQKPtrssqspaDRSSWlsnPSIPNASWI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     206.73|      59|     133|     268|     332|       8
---------------------------------------------------------------------------
  268-  327 (109.38/54.36)	HQLHSH.......SNSTLQSSLAL....DEQLGLAGPQSAG.......YFSPSHIEFNPWHGCSPCKWKVPLLQSgLP
  340-  372 (23.21/16.30)	.......................................SIdedvdeiHYSASHVQEEEWK....IRWA.KLLLS.LP
  402-  462 (74.14/30.42)	HQLHAHklhfvfdSEGNEENELCLivwvYEIPGQLGPKT...........SPTENTL.PDHAKSSNHQGPPPL.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.36|      11|      15|       3|      13|      14
---------------------------------------------------------------------------
    3-   13 (22.01/11.10)	DSPNHQRNNNN
   19-   29 (21.35/10.56)	NNNNNNNNNNN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.29|      10|      26|     215|     224|      15
---------------------------------------------------------------------------
  215-  224 (21.58/ 8.22)	TLPHPPKPYK
  244-  253 (20.71/ 7.52)	THHHPPSCSK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19224 with Med13 domain of Kingdom Fungi
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