Description | Mediator of RNA polymerase II transcription subunit 6 |
Sequence | MNSTIAGLAIPAESDLCHVQWRSMAWILEHGPLTETNVMDYFSLSPFYDRKSTNQVLRMQSMFSGQPKMDPLAEQEALKRLIGVQYAVVLARPEPDREGGLFIIEKRIRKADDQYYPIASYYVLKTSIYQAPSLYATLSSRVLTSLSSLKQLLDLARQHKPTYDPRQSYAWKIKEKVETTYEQDATEDQVPPDPATVPDPSSSTHDSDKMDMDAPSSPKKDNDHDAPANTTAPSARQSNKHTPELANPILFRALQNTLNNFAAFKPPKPQELVPERVPIPASSAPSPP |
Length | 288 |
Position | Head |
Organism | Puccinia coronata var. avenae f. sp. avenae |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Basidiomycota> Pucciniomycotina> Pucciniomycetes> Pucciniales> Pucciniaceae> Puccinia. |
Aromaticity | 0.08 |
Grand average of hydropathy | -0.615 |
Instability index | 62.98 |
Isoelectric point | 5.90 |
Molecular weight | 32240.01 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364143 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP19220 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 39.07| 14| 17| 214| 229| 1 --------------------------------------------------------------------------- 214- 229 (17.81/14.87) APSSpKKDNDHdAP..AN 232- 247 (21.25/ 7.74) APSA.RQSNKH.TPelAN --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 58.72| 18| 18| 103| 120| 2 --------------------------------------------------------------------------- 103- 120 (30.18/16.39) IIEKRIRKADDQYYPIAS 123- 140 (28.54/15.18) VLKTSIYQAPSLYATLSS --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 48.74| 13| 78| 191| 203| 3 --------------------------------------------------------------------------- 191- 203 (27.56/12.87) PPD.....PATVPDPSSS 266- 283 (21.18/ 8.37) PPKpqelvPERVPIPASS --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) ELVPERVPIP 2) ILFRAL | 271 249 | 280 254 |
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