<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19217

Description Uncharacterized protein
SequenceMAHNLIKPSRLSHAQPPENQNAQPSSDKSPSSLDVYQLQPPRWRLPTQLNRPDLGYPGLHPTHIGQHEDAITKSLVQWGFSAQMLVSTESFSAHQMIYKKITEETAFNVSSSALSALIEARRRYCAMNSYDTKSTIKVPGRVTLNEQKRENWLRELADDSVPLLKLSKNVPHGFKGEKLLEMLVSRKIECSRATWYIRLIGLNEINAQRNKNDLSHIRYTLSFTPEVCQFLQKQLAEVTVPLQMNLSSSTTSLITTSSRLAAMNVRSKPRSSTLSDPETRKHWVAKWTQSCMLLKRLIFESLLDQPSFFKWIIDQMKVANLAQIHFLLDIYHSVFERFNLSSNLVRSFVEACLFQIRFIAKQTATSYLSKLERRLKLAVQSAFTFCPDNFVWPDLWIPNKSLLQEIILADFLGDPDNSSLEQSSAPNQLREILTGDFYAVNWRVTELIGDVGIGTGIVGNIFTRRAQLVEILDSYSDYSDCSKLYYKYFLHPSVAGHISVSFKDKLEVLLSWATTLFRNSDKRVHLVASTLSYVKKDYKKNGDEFQNILVGWLEQIESTEGGDLLVRLFSELSRRNIFSYGAYVQRMVAKGDTECDILGGKASGVQALLSEWMPLASSRSSRERSNSIKRSPGRDFARNGLMAIIADFNSAIASADYGKFTSLLSRRLDARQPTSANRKLVAEILPKALVHLFSELAFVSVSGSPVSRTAHHPELASALLTWGFQLLESCQAYATLFEIMQRIVQIDLSRLEALRSDEGERTDLSLSFQSTFCYLQIICMSALNNKDIMEISGQLTDLVSRLFAIHFHFRRVVGGTSTAVRGFVRCLRNLVLESNDVDPQILEVLDKEYHPIFDEMTNGSMTGETLPSRTKEILQLLQCPSTEQVSLLVHKYWEAYRSDMDWGPALWNSLIAAIKIHSQEEFNELLVKNPDDSVQSPNDNMGEFREVLVQLCEDLDMLYEEGLIGCLIRAGYITYPHPDDEALFTRPAHASESKMTTEEEEGEENEGTSTAGQSLKDLFFHNPRSLCRNIRRLLLELMSSGLISIEVALEEYVIRPLADDVPQQLGSLYGDSSYDVTRVHQTIQVEEALRQVEEIHLLVNEVLCEPRVNRYSPGFSQSPDKESGVMMTPSRSRSDGHLSLMNQDTSDSSHRSKEVEYVIVDYVRTGRLDVERKLWFEQSEEGSAFCSRLLLSLLISMKTISELSFEPEVAENSAAQQPPPFEQLIPKILDAFESLREAVCQGSDLLRRQIPLQAAVFLDPILELVTKNDLGTIFHTKLIHSIDELLPYSQSSELVNHKYPYLESIFKESCIFNHAARTRQFQLHIRLLMSTNPPQMPMTKETLIDVASTLGALVEVMAKRLHLTDSKDAAPFFLDCLPLQVAEALIIKLSLYLGMSICKLLGPNSADSALEVLRIHHICRCITTLTNQLTIRTYQSSDDVASKVVGGCGPLGCNATIESYLSYWQQLKSGLTLLNSRLATSDPTTLSPRRMEYRIMRALLHSTQVVLWSLPGLTQQLGTLKQTIAEIWIEISLRVQGDSALQNQIMDTIGVLLFPTVPDDSCLTATVGILRKRFRWLYLPILNMDDGANLVPSNRLKYLLGCSMRGSSTIFQERPSDGAVKFLEEKPWEELEKMDVSGPGFISIDALKCQTLSHVEQIPEAKPSGSRQPKLKSGKSEGEDVLAEEIEPGGERGSDQPMGGLQHALNEDGGAEEEEEGPETGDRHSFEHELITDGLSTIPLHFLRSLYPPASRLLGTDWLVAVEQQKLEQAEQAEQTRSKQQQQQQQQQAANEGATEQNSGRLKKRKGVALSPSPAEQIGSSSSTGPTLRSARSTRKKSTAAAPANPPPTASSSKRVKKR
Length1859
PositionKinase
OrganismPuccinia coronata var. avenae f. sp. avenae
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Pucciniomycotina> Pucciniomycetes> Pucciniales> Pucciniaceae> Puccinia.
Aromaticity0.07
Grand average of hydropathy-0.280
Instability index55.36
Isoelectric point5.93
Molecular weight208753.41
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP19217
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     217.75|      70|     288|    1083|    1260|       1
---------------------------------------------------------------------------
  117-  196 (108.22/28.66)	LIEAR.RRYCA..MNSYDTKSTIKV.PGRvtlneQKRENWLRELADDSVPLLKLSKNVPHGfkgekLLEMLVSRKIECSRATWY
 1103- 1176 (109.53/186.27)	LCEPRvNRYSPgfSQSPDKESGVMMtPSR.....SRSDGHLSLMNQDTSDSSHRSKEVEYV.....IVDYVRTGRLDVERKLWF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      82.17|      18|      19|    1686|    1703|       2
---------------------------------------------------------------------------
 1658- 1675 (26.99/12.02)	I.PEAK.PSGSRQPKLKSGK
 1686- 1703 (34.37/17.24)	I.EPGG.ERGSDQPMGGLQH
 1705- 1724 (20.81/ 7.66)	LnEDGGaEEEEEGPETGDRH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     136.60|      41|     287|    1216|    1260|       3
---------------------------------------------------------------------------
 1216- 1260 (65.29/58.24)	QQPPPFEQLIPKILDAFeSLReavCQGSDLLRRQIPLQAAVFLDP
 1515- 1555 (71.31/50.16)	QQLGTLKQTIAEIWIEI.SLR...VQGDSALQNQIMDTIGVLLFP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     256.67|      95|     288|     336|     453|       4
---------------------------------------------------------------------------
  336-  433 (153.26/119.90)	ERFNLSSNLVRSFVE..AC..LFQIRF....IAKQTATSYLSKLERRLKLAVQSAFTFCPDnfVWPDLWIPNKSLLQEIiLADFL.GDPDNSSLEQSSAPNQLREIL
  463-  513 (33.82/ 7.92)	TRRAQLVEILDSYSDysDCskLYYKYFlhpsVAGHISVSFKDKLEVLLSWA........................................................
  895-  948 (69.59/28.12)	..................................................AYRSDMDWGPA..LWNSLIAAIKIHSQEE.FNELLvKNPDDSVQSPNDNMGEFREVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.61|      12|      20|    1826|    1837|       5
---------------------------------------------------------------------------
 1826- 1837 (19.95/12.98)	PTLRSARSTRKK
 1848- 1859 (19.66/12.67)	PTASSSKRVKKR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.01|      28|     137|      88|     115|       6
---------------------------------------------------------------------------
   88-  115 (48.11/32.34)	TESFSAH..QMIYKKITEETA...FNVSSSALS
  220-  252 (37.90/23.81)	TLSFTPEvcQFLQKQLAEVTVplqMNLSSSTTS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     179.31|      58|     137|     605|     666|       7
---------------------------------------------------------------------------
  605-  666 (83.22/70.82)	VQALLSewmPLASSRSSRERSNSIKRSPGRDFARNGLMAIIADFNSAIASADyGKFTSLLSR
  744-  801 (96.08/65.23)	VQIDLS...RLEALRSDEGERTDLSLSFQSTFCYLQIICMSALNNKDIMEIS.GQLTDLVSR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.21|      24|     809|     667|     691|      10
---------------------------------------------------------------------------
  667-  691 (35.25/25.54)	RLDARQPTS.ANRKLVAEILpKALVH
 1477- 1501 (38.96/22.95)	RLATSDPTTlSPRRMEYRIM.RALLH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.69|      23|     287|     692|     728|      14
---------------------------------------------------------------------------
   61-   85 (38.83/12.82)	PTHIGQHEDAITKSLVQWGFsaQML
  705-  727 (41.86/16.22)	PVSRTAHHPELASALLTWGF..QLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.92|      20|      21|    1763|    1782|      15
---------------------------------------------------------------------------
 1763- 1782 (32.19/26.55)	EQQKL.EQAEQAEQTRSKQQQ
 1786- 1806 (27.73/21.55)	QQQAAnEGATEQNSGRLKKRK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19217 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FTRPAHASESKMTTEEEEGEENEGTSTAGQS
2) LGTDWLVAVEQQKLEQAEQAEQTRSKQQQQQQQQQAANEGATEQNSGRLKKRKGVALSPSPAEQIGSSSSTGPTLRSARSTRKKSTAAAPANPPPTASSSKRVKKR
3) NLIKPSRLSHAQPPENQNAQPSSDKSPSSLDVYQ
4) PGFSQSPDKESGVMMTPSRSRSDGHLSLMNQDTS
5) VEQIPEAKPSGSRQPKLKSGKSEGEDVLAEEIEPGGERGSDQPMGGLQHALNEDGGAEEEEEGPETGDRHSFEHELITDG
984
1754
4
1113
1655
1014
1859
37
1146
1734










Molecular Recognition Features






MoRF SequenceStartStop




1) ARSTRKKSTAAAPA
2) NSGRLKKRKGVALSPSPAE
3) PTASSSKRVKKR
1831
1798
1848
1844
1816
1859