<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19212

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMEAGEYTTNTLVINNITSIAYRTYELSATDQYQSQPNPTVIQDVESLFRTQGCIAHFDTSRRIIWHFGVTTRENATSSFSTGPPLPDNLDIPGVTLSPVDDGSFEPMSLSRPRIPQQGSNTPTGGLPGTASLDTTHQHKSAASFSPASSSSWGVADQEAKSLSVSGIDLKAASLGAITVNDAYENFILALLGTILADFVQRTGALPLDNRTVLVTPSQQFGDVQDSISSAASATASFRLYLTPTGTLVINLGLHTGEGLLPLSKPQLPLFSLPFTETPIFVAPFGLRALSQGVSDIGLSHSDTGVAQTPDTQISRFQDTRTSRWRQICSRLLQLKGIPAQVLDSCPWVTIRVPRQKLYDQRVDGMPHSIITTSTAIAWPACLCFRRCNASMPPMSRLGGNMLVGRDESYDPLERARSWFQEAPERSETIAKRKKERETVVSKEPADVDSRTRQQVNGSSPLAFQRAANVAALAAGVMYPTPPDAIQNPSAPTPSLDGAAVASPNAQPPSLAVVDADVAMANAAPLSDTYPERDRNEAPYLGDSDALFGDLSGDMFPDGEVTDADFSFFDDHPGGSNVDVDVDMLTADLGNAEPQLPPPEPSQRSIADPLPVPPSLPTSTSEAGTSSQSETKGLTMKRESPVFAKPELRHARSVLGDDSKSASKAKNGSIVKREHSPFDPDTVFKRVRTALYRSNRPNSSQPTRRRSVYDKVEFDVLVPPVTSKYVNGGKYAFNWSPIKDNMKDKAPPTTDYLRRHGKNGKNLKALPENHGALIARITTGLESSSITASPAKLDGLADLDVDDMSTVSDQDDTSVSSEEPFSPVKSAGLRRANNEDDLISHATSLRDVELPDDSDPSFVLELPRLGRAGTAEMPVAKFFADPEPLALQLNLLDDDMIAIAQILTEQAALGTLEILSDNPLRKPPLPCPIRRRQLASLSRQVLHALRDSLPMCLSGASECQLRAFSEIQDGTPSLGPPSRPLLQPRQVPGRDPSTAVPPTVYQIPPPHLEVKRAETRLSVLPSAALFWESLGLGPSMGPKNVCAACVFPGWDGMADNISAFLERMKSVYESMKLGSFERLESTESIADGLVRYDVDKISMTPGTVFPRISSALAERIDLLCQALRGTTVSSKNLVIFFVYSPANPSSIVEACTSFHQLSEAYKSGLSGKSQASSNEVILQLVPSDFVCATSSVVIQPQVDLLKLCLETYDRCTLFNGPTPAPAILLEQVAPRFIDFSLAATPSASVMHENSCIHVAYARSTNGRWVTATWTDSRGSQQMMASYCLGRKGRPLATPFTDVALEIWETTHDLMSTWKVHWRIVITKCGPMDADEMEFWTGLAQTESKARVSLVLMTVDTSPSLQLLPPAIRLNPSMSVSFYTTPASTPQASILSPEQSGNPATPANAPTPSDANATDGTSADGILVDVMDQSWGCVLGHRLNNSTSPTEINPALFSGYLIKRGGTKAEDPPVVMEVNVIYSDGSPRQHEGLLREMLGHFRALGTLARVRGVTDKETDVRPWHVAAAEKGVRALYLLM
Length1533
PositionKinase
OrganismLomentospora prolificans
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Microascales> Microascaceae> Lomentospora.
Aromaticity0.06
Grand average of hydropathy-0.261
Instability index49.26
Isoelectric point5.30
Molecular weight165686.06
Publications
PubMed=28963165

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP19212
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     176.68|      45|      46|     480|     524|       1
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  480-  524 (77.48/35.20)	TPPDAIQN............PSAPTPSL.DGAAVAS..PNAQPPSLAVVDADVAMANAAP
  528-  572 (64.62/28.07)	TYPERDRN............EA...PYLgDSDALFGdlSGDMFPDGEVTDADFSFFDDHP
  573-  615 (34.57/11.41)	GGSNVDVDvdmltadlgnaePQLPPPEP.SQRSIAD..PLPVPPSL..............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|      91.71|      21|      51|     912|     932|       2
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  912-  926 (22.99/ 8.73)	............EILSDN.PLRKPPLP.C
  927-  951 (19.96/ 6.53)	PIRRRQlaslsrQVL..H.ALR.DSLPmC
  954-  979 (28.56/12.79)	GASECQ.lrafsEIQDGT.PSLGPPSR.P
  980-  995 (20.21/ 6.71)	LLQPRQ............vPGRDPSTA.V
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.38|      30|      33|     788|     819|       3
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  788-  817 (49.91/28.19)	SPAKLDGL..ADLDVDDMSTVSDQDDTSVSSE
  821-  852 (44.47/27.66)	SPVKSAGLrrANNEDDLISHATSLRDVELPDD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     244.58|      75|     879|     285|     448|       4
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  346-  430 (124.26/187.80)	PWVTIRVPRQKLYDQRVD....GMPhsiittSTAIAWPAcLCFrrcNASMPPMSRLGGNMLVGRDESYDP....LERARSWFQ.......EAPERSETIA
  996- 1085 (120.32/43.89)	PPTVYQIPPPHLEVKRAEtrlsVLP......SAALFWES.LGL...GPSMGPKNVCAACVFPGWDGMADNisafLERMKSVYEsmklgsfERLESTESIA
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---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     150.77|      43|      46|    1170|    1215|       5
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 1141- 1166 (31.76/15.31)	.................ANPSSIVEACTSFH..QLS.E.AYK..SGLSG
 1170- 1215 (61.62/51.52)	ASSneVILQLVPSDFVcATSSVVIQPQVDLL..KLCLE.TYDRCTLFNG
 1219- 1261 (57.39/35.98)	APA..ILLEQVAPRFI..DFSLAATPSASVMheNSCIHvAYARST..NG
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.75|      24|     878|     203|     230|       8
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  203-  230 (36.22/35.52)	GALPLDNRTVLVTPsqqfGDVQDSISSA
 1087- 1110 (43.52/30.21)	GLVRYDVDKISMTP....GTVFPRISSA
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19212 with Med13 domain of Kingdom Fungi
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