<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19212

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMEAGEYTTNTLVINNITSIAYRTYELSATDQYQSQPNPTVIQDVESLFRTQGCIAHFDTSRRIIWHFGVTTRENATSSFSTGPPLPDNLDIPGVTLSPVDDGSFEPMSLSRPRIPQQGSNTPTGGLPGTASLDTTHQHKSAASFSPASSSSWGVADQEAKSLSVSGIDLKAASLGAITVNDAYENFILALLGTILADFVQRTGALPLDNRTVLVTPSQQFGDVQDSISSAASATASFRLYLTPTGTLVINLGLHTGEGLLPLSKPQLPLFSLPFTETPIFVAPFGLRALSQGVSDIGLSHSDTGVAQTPDTQISRFQDTRTSRWRQICSRLLQLKGIPAQVLDSCPWVTIRVPRQKLYDQRVDGMPHSIITTSTAIAWPACLCFRRCNASMPPMSRLGGNMLVGRDESYDPLERARSWFQEAPERSETIAKRKKERETVVSKEPADVDSRTRQQVNGSSPLAFQRAANVAALAAGVMYPTPPDAIQNPSAPTPSLDGAAVASPNAQPPSLAVVDADVAMANAAPLSDTYPERDRNEAPYLGDSDALFGDLSGDMFPDGEVTDADFSFFDDHPGGSNVDVDVDMLTADLGNAEPQLPPPEPSQRSIADPLPVPPSLPTSTSEAGTSSQSETKGLTMKRESPVFAKPELRHARSVLGDDSKSASKAKNGSIVKREHSPFDPDTVFKRVRTALYRSNRPNSSQPTRRRSVYDKVEFDVLVPPVTSKYVNGGKYAFNWSPIKDNMKDKAPPTTDYLRRHGKNGKNLKALPENHGALIARITTGLESSSITASPAKLDGLADLDVDDMSTVSDQDDTSVSSEEPFSPVKSAGLRRANNEDDLISHATSLRDVELPDDSDPSFVLELPRLGRAGTAEMPVAKFFADPEPLALQLNLLDDDMIAIAQILTEQAALGTLEILSDNPLRKPPLPCPIRRRQLASLSRQVLHALRDSLPMCLSGASECQLRAFSEIQDGTPSLGPPSRPLLQPRQVPGRDPSTAVPPTVYQIPPPHLEVKRAETRLSVLPSAALFWESLGLGPSMGPKNVCAACVFPGWDGMADNISAFLERMKSVYESMKLGSFERLESTESIADGLVRYDVDKISMTPGTVFPRISSALAERIDLLCQALRGTTVSSKNLVIFFVYSPANPSSIVEACTSFHQLSEAYKSGLSGKSQASSNEVILQLVPSDFVCATSSVVIQPQVDLLKLCLETYDRCTLFNGPTPAPAILLEQVAPRFIDFSLAATPSASVMHENSCIHVAYARSTNGRWVTATWTDSRGSQQMMASYCLGRKGRPLATPFTDVALEIWETTHDLMSTWKVHWRIVITKCGPMDADEMEFWTGLAQTESKARVSLVLMTVDTSPSLQLLPPAIRLNPSMSVSFYTTPASTPQASILSPEQSGNPATPANAPTPSDANATDGTSADGILVDVMDQSWGCVLGHRLNNSTSPTEINPALFSGYLIKRGGTKAEDPPVVMEVNVIYSDGSPRQHEGLLREMLGHFRALGTLARVRGVTDKETDVRPWHVAAAEKGVRALYLLM
Length1533
PositionKinase
OrganismLomentospora prolificans
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Microascales> Microascaceae> Lomentospora.
Aromaticity0.06
Grand average of hydropathy-0.261
Instability index49.26
Isoelectric point5.30
Molecular weight165686.06
Publications
PubMed=28963165

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP19212
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     176.68|      45|      46|     480|     524|       1
---------------------------------------------------------------------------
  480-  524 (77.48/35.20)	TPPDAIQN............PSAPTPSL.DGAAVAS..PNAQPPSLAVVDADVAMANAAP
  528-  572 (64.62/28.07)	TYPERDRN............EA...PYLgDSDALFGdlSGDMFPDGEVTDADFSFFDDHP
  573-  615 (34.57/11.41)	GGSNVDVDvdmltadlgnaePQLPPPEP.SQRSIAD..PLPVPPSL..............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|      91.71|      21|      51|     912|     932|       2
---------------------------------------------------------------------------
  912-  926 (22.99/ 8.73)	............EILSDN.PLRKPPLP.C
  927-  951 (19.96/ 6.53)	PIRRRQlaslsrQVL..H.ALR.DSLPmC
  954-  979 (28.56/12.79)	GASECQ.lrafsEIQDGT.PSLGPPSR.P
  980-  995 (20.21/ 6.71)	LLQPRQ............vPGRDPSTA.V
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.38|      30|      33|     788|     819|       3
---------------------------------------------------------------------------
  788-  817 (49.91/28.19)	SPAKLDGL..ADLDVDDMSTVSDQDDTSVSSE
  821-  852 (44.47/27.66)	SPVKSAGLrrANNEDDLISHATSLRDVELPDD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     244.58|      75|     879|     285|     448|       4
---------------------------------------------------------------------------
  346-  430 (124.26/187.80)	PWVTIRVPRQKLYDQRVD....GMPhsiittSTAIAWPAcLCFrrcNASMPPMSRLGGNMLVGRDESYDP....LERARSWFQ.......EAPERSETIA
  996- 1085 (120.32/43.89)	PPTVYQIPPPHLEVKRAEtrlsVLP......SAALFWES.LGL...GPSMGPKNVCAACVFPGWDGMADNisafLERMKSVYEsmklgsfERLESTESIA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     150.77|      43|      46|    1170|    1215|       5
---------------------------------------------------------------------------
 1141- 1166 (31.76/15.31)	.................ANPSSIVEACTSFH..QLS.E.AYK..SGLSG
 1170- 1215 (61.62/51.52)	ASSneVILQLVPSDFVcATSSVVIQPQVDLL..KLCLE.TYDRCTLFNG
 1219- 1261 (57.39/35.98)	APA..ILLEQVAPRFI..DFSLAATPSASVMheNSCIHvAYARST..NG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.75|      24|     878|     203|     230|       8
---------------------------------------------------------------------------
  203-  230 (36.22/35.52)	GALPLDNRTVLVTPsqqfGDVQDSISSA
 1087- 1110 (43.52/30.21)	GLVRYDVDKISMTP....GTVFPRISSA
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19212 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ADLDVDDMSTVSDQDDTSVSSEEPFSPVKSAGLR
2) FEPMSLSRPRIPQQGSNTPTGGLPGTASLDTTHQHKS
3) GEVTDADFSFFDDHPGGSNVDVDVDMLTADLGNAEPQLPPPEPSQRSIADPLPVPPSLPTSTSEAGTSSQSETKGLTMKRESPVF
4) KPELRHARSVLGDDSKSASKAKNGSIVKREHSPFDP
5) MYPTPPDAIQNPSAPTPSLDGAAVASPNAQPPSLAVVDADVAMANAAPLSDTYPERDRNEAPYLGDSDALFGDLSGDMF
6) PQASILSPEQSGNPATPANAPTPSDANATDGTSA
7) PSLGPPSRPLLQPRQVPGRDPSTAVPPTVYQIPP
8) QEAPERSETIAKRKKERETVVSKEPADVDSRTRQQVNGSSP
9) TVFKRVRTALYRSNRPNSSQPTRRRSVYDKV
796
104
558
644
477
1384
971
420
681
829
140
642
679
555
1417
1004
460
711










Molecular Recognition Features






MoRF SequenceStartStop




1) DYLRRH
2) EVTDAD
3) VFKRVRTA
750
559
682
755
564
689