<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19203
Description |
Mediator of RNA polymerase II transcription subunit 17 |
Sequence | MEHTDAQNAIRPWPIADADRKPKTISDYISLVNQTYPGGFRALNIDKINDGTIDESRDTKMVDVDGERNAGDSDDSLSGKDPVEARNESLQNIIVAHHSALFALDLVSLLLTKEAPVQAGLTLRQDLRDLVGIGTLASQKHAESNVTPDKMKDLGDITAGWHILSVEETRDSAKKAAGLLQEEVEKEAKFWDDVLSVAEAGWSVCRFPQERQTLGVKFGFNEASAEFRKNSLAPMRRAGDGSVELDLGNLGGQAQRLVVTVERDGIVTGIASQLVPAHVGDKGPLSAHVLEARNTIYARELWHELQMEARNLQSFDVRQYESSIVYTRPNGMKVRLELLSADSCPPVEHGLPENWLAESIHVSLHVLLGYAHRQNEIMRSRPWPPNQPRSRLQNQHYLLRPIIARLVHMEAIEDCTKYIGTLVKCLQNGKVSDAKFELATAQNKMTDLSTTSSDRVRSNPTQAVLGGITAPLVFLLEVTITPGNRVSILGRTWLRATATVYQITLPVTNPETPNTLVESCPPHRDYPNLAEVRCYVDQAVSCAMANYFQPRLEDAEKEGLLQKYGSLESPPASEGLDIEENAFWVKSVSGTSLHTSATSPREISFTVGGPTLNPHLEVTTMVRNEGAKVVKHVWNGEGSGGDTTEFGLSDVCLGLVKDVYS |
Length | 661 |
Position | Head |
Organism | Lomentospora prolificans |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes>
Hypocreomycetidae> Microascales> Microascaceae> Lomentospora.
|
Aromaticity | 0.06 |
Grand average of hydropathy | -0.348 |
Instability index | 40.61 |
Isoelectric point | 5.39 |
Molecular weight | 72717.13 |
Publications | PubMed=28963165
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364140
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP19203
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 510.06| 179| 225| 209| 433| 1
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213- 433 (265.98/311.40) TLGVKF.GFNEASAE.FRKNslaPMRRAgdgsveldLGnlggqaqrlvvtverdgivtGIASQL.....VPAHVGDKGPLSAHV.LEARNTIYAREL................WHELQMEARNLQSFdVRQYESSIV..YTRPNGMKVRLE.LL....SADScPPVEHGL..PEN..WLAESIHVSLHVllgYAHRQNEIMRSRPWPPNQPRSRLQNqhyLLRPIIARLV.HMEAIE....DCTKYiGTLVKCLqnGKVSD
440- 658 (244.08/180.38) TAQNKMtDLSTTSSDrVRSN...PTQAV........LG....................GITAPLvflleVTITPGNRVSILGRTwLRATATVYQITLpvtnpetpntlvescpPHRDYPNLAEVRCY.VDQAVSCAManYFQPRLEDAEKEgLLqkygSLES.PPASEGLdiEENafWVKSVSGTSLHT...SATSPREISFTVGGPTLNPHLEVTT...MVRNEGAKVVkHVWNGEgsggDTTEF.GLSDVCL..GLVKD
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 49.99| 13| 39| 159| 171| 2
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159- 171 (23.74/11.89) AGWHILSVEETRD
200- 212 (26.24/13.75) AGWSVCRFPQERQ
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