<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19202

Description Uncharacterized protein (Fragment)
SequencePTPLVLGGQPPVASHERPFSSLLLIPSLFSISRHGDAGPFSTMTSRTSMGAQPPRPPQRTLSSPGLPGQLPPHQRTLSQQYLPPSPIRKESSMDSSYDSNDVAQNRYNTAPRRGGSRLKLELSTDAIMAEPTTYESPQPIQSRITPMNESSDTVHPSPSGSIRPGYLEPDNTQLPMPKRRARFSRAVPKSRPAPAPAPTPAAANKDNRPKPYTVEYPQEAPRYRQVKLDATRTSSELPRVSNSGYADFFPWSGDHPEDQFSETVIRSGYFHKAPPNQAEAATAKPALFPLLKQKNCLNALSSVFLGVLAQRRHSGQITAPSTFKPPPRVTLTDTKREMWLKDLANPATSLRRLSRTIPHGIRGKVLLEHCLNKNVPTERAVWLAKCVGANDLRAFRRKGVNQTFMGGETKWIRDWTVFVEQFVETVFSSFEMPDWKSKVTYAIRLATNLYTEQLLDRDHYMEWLLSGLESTPQSKLPMWILILQLYWKDLLRLRKTGRRLVASLLNHLTAVQSDPDRDLLIQLSSLITSLLTSLMISNPESFVSPTTWPKHRDALVELIQQADGPTRAAYHLIDSRNNRLVSGSDSASPQSMQQRLVKLLDVTLHQPFNDSFVSQCWASGPDKTAILRTVLDWGTSPLRPGSAKVYVTVRLLRSWSKQGLDITAAVLEYLDLIPADDQERKKLVYAIVSDLARSFDFSVARYIQWLISRGGLSNPEEIGSEGPCSTRLLVELPTHALNPSLRCMRGNLLRRASFDVEEEKMDVENAIKLVKQGLGLPLSPDDPISQRKPMPASRLAKPVSRSSRGLQTSIGAFLRDQVFAPAARTTEGPGISCAMFNYSRTVLEAANDFEMLLGTVALASKISNPELLASCTETVNVHLTTFAAMEDVKKLFDSLMASFKTISDTQGLAPARVLLASLASLADRIPGLEDQGRQLRSELLRCDRTSGIDACSPVSDNMAGYMQDIEGTLYEEVEKVLSTGTRVDQPTMDRLFRTIIGRLESCWSKSIEAQRGCIPLLTRLRAFDAQHFDEKMAQWVGTVKTRVGRPPLVDIFPLLIGQGCLGLTTILKAYLPNAPSPVSTSPSGPYLQETLQLTSMRLPQSTILMPEECCRFYIQQRTLLSRHSDQLRRLLNSALAEYCEMGGKIGGSGLLLDGPGCWPAVLDLFKNLVLIDPSGLAQDYTCNVSPPSLRQLVDMLATQALGLGDGSGPQISFDSILEMANELSLPFCQVKLSLSLSDESEMAADHQTESHISLFTKAMERAIEANNVMWTSMLPHLNDTIAQHVRNEARSRFIDLVPSFKTPSSANLGDERSLRAAESLVSVMESITSGHPASKATQLTPSISEKVSDLWDILSSNEEEKKRLHILVLTGWLPLMLKFVAMHIGPAAEPAPAPTPGGNTIRPPPNPAQTELKAKVLLALAGIFQELDALDPAEAQVAQNCGLAEQVLDVAMVLVDGLPDEARAHCCRLVLISEPTALQNASSDPRLRYLLSYMPPQDNLMLSPRNRMSMQGGSTRTAMLGAPGQAEKLMPFSYRRWEVLNEPTPNVGENDTSPSLTLFEAIKLR
Length1565
PositionKinase
OrganismLomentospora prolificans
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Microascales> Microascaceae> Lomentospora.
Aromaticity0.06
Grand average of hydropathy-0.276
Instability index54.50
Isoelectric point8.32
Molecular weight172763.90
Publications
PubMed=28963165

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP19202
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     320.05|      78|     102|      64|     165|       1
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    3-   62 (76.60/22.78)	PLVLGGQP.PvasHERPFSSLLLIPSLFSISRHGDAGPFSTMTSRTSMGAQPPRPPQR...TLS......................
   64-  145 (120.38/52.12)	PGLPGQLP.P...HQRTLSQQYLPPSPIRKESSMDSSYDSNDVAQNRYNTAPRRGGSRLKlELSTDAIMaepTTYESPQPIQSRIT
  168-  246 (123.07/68.13)	EPDNTQLPmP...KRRARFSRAVPKSRPAPAPAPTPAAANKDNRPKPYTVEYPQEAPRYR.QVKLDATR...TSSELPRVSNSGYA
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     299.21|      84|      99|    1013|    1100|       2
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  284-  331 (37.84/14.57)	.......................................KPAL...FPLLKQKNCLnALSSVFLGVLAQrRHSGQI....TAPStfKPPPRVTL.........
 1013- 1100 (139.80/85.24)	CIPLLTRLRAFDAQHFDE.......KMAQWVgTVKTRVGRPPLvdiFPLLIGQGCL.GLTTILKAYLPN.APSPVS....TSPS..GPYLQETLQLTSMRLPQ
 1109- 1199 (121.57/64.39)	CCRFYIQQRTLLSRHSDQlrrllnsALAEYC.EMGGKIGGSGL.....LLDGPGCWpAVLDLFKNLVLI.DPSGLAqdytCNVS..PPSLR...QLVDMLATQ
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     309.21|      97|      98|    1271|    1368|       3
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 1271- 1368 (153.70/92.54)	TSMLPHLNDTIAQHVRNEARSRFIDlVPSFKT..PSSANLGDERSLRAAESLVSVMESITSGHPASKATQLTPSISEKVSDLWDILSSNEEEKKRLHI..LV
 1370- 1470 (155.50/89.93)	TGWLPLMLKFVAMHIGPAAEPAPAP.TPGGNTirPPPNPAQTELKAKVLLALAGIFQELDALDPAEAQVAQNCGLAEQVLDVAMVLVDGLPDEARAHCcrLV
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.61|      28|     345|     630|     657|       5
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  630-  657 (51.59/26.41)	VLDWGTSPLRPGSAKVYVTV..RLLRSWSK
  976- 1005 (47.02/23.45)	VLSTGTRVDQPTMDRLFRTIigRLESCWSK
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.82|      18|     103|     146|     167|       6
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  146-  167 (28.46/29.32)	PMneSSDtvHPSPSGS...IRPGYL
  250-  270 (34.36/20.48)	PW..SGD..HPEDQFSetvIRSGYF
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     194.55|      68|     342|     494|     567|      10
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  494-  567 (110.86/83.21)	RKT.GRRLVASLLNH.LTAVQSDPDRDLLIQLSSLITSlltslmISNPESFVSPT.TWPKHR.............DALV...ELIQQADG..PTR
  824-  912 (83.69/51.87)	RTTeGPGISCAMFNYsRTVLEAANDFEMLLGTVALASK......ISNPELLASCTeTVNVHLttfaamedvkklfDSLMasfKTISDTQGlaPAR
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19202 with Med12 domain of Kingdom Fungi
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