<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19201

Description Mediator of RNA polymerase II transcription subunit 4
SequenceMDKAIDSRFERLERALAALIDSVAKYNPSATQARDLENADHELSQGLDEVQAHQNNYLRIQKLREESRALDDQIRECLTGLASTRKDVLSIQTTVFPTKPGYAFTYGELLNYARRISKTTMPPPGVTNGVVFPPSDGENRDMTPVLNGQGVAGSAAQTPSATQPATPLSQQPSELQSQQLTTSQITSLPENLSFHLNPHAGSLFFPWPLEDKIRSGALSSNQLLEEQGIDPKNYDPVAEEERKQREEEEKRQREEEERIRREEQERKVREERERAILERAKRREEEQAEGWRKSSVAGASSGQPTSSTAGPGEKKQFQFTSIDDMDDED
Length329
PositionMiddle
OrganismLomentospora prolificans
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Microascales> Microascaceae> Lomentospora.
Aromaticity0.05
Grand average of hydropathy-0.990
Instability index60.24
Isoelectric point4.97
Molecular weight37009.28
Publications
PubMed=28963165

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats
>MDP19201
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.61|      19|      21|     245|     264|       1
---------------------------------------------------------------------------
  245-  264 (29.96/19.85)	REEEEKRQREEEERiRREEQ
  269-  287 (31.65/16.64)	REERERAILERAKR.REEEQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.21|      20|      21|     143|     163|       2
---------------------------------------------------------------------------
  125-  149 (28.05/18.96)	GVTNGVVFPPSdgenRDM..TPvLNGQ
  150-  171 (30.16/16.16)	GVAGSAAQTPS....ATQpaTP.LSQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.34|      20|      22|      80|     100|       3
---------------------------------------------------------------------------
   80-  100 (30.67/26.79)	GLASTRKDVLS....IQTTVFPtKP
  101-  124 (32.67/23.05)	GYAFTYGELLNyarrISKTTMP.PP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19201 with Med4 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) RISKTTMPPPGVTNGVVFPPSDGENRDMTPVLNGQGVAGSAAQTPSATQPATPLSQQPSELQSQQLTTSQITSLPENLS
2) SGALSSNQLLEEQGIDPKNYDPVAEEERKQREEEEKRQREEEERIRREEQERKVREERERAILERAKRREEEQAEGWRKSSVAGASSGQPTSSTAGPGEKKQFQFTSIDDMDDED
115
215
193
329










Molecular Recognition Features






MoRF SequenceStartStop




1) QAEGWRKSSVAGA
2) TAGPGEKKQFQFTSIDDMDDED
287
308
299
329