<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19198

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMAMQTDNPVDSNGMPFLENSLPAVLPDVDDLFGGEVPVNLALSPPTKELRQRIDDIRRRGCCQTVAWSKAGIIASLTPDGHFVELRFLRCNPDDGSWQLSEPTRCDLVVGSDSIPLAHLAWSSTAIPELAILDSVGRLALLTFSNAINRPYLTRRWDPDPIDDLNAVVGCHWLSLMPPSRQFNVLHGPAIKDSNRYRYDTSFIHSFGPFHPNPSKSSLLCVTTNGQLKLFYSQSNNRIEETTIDIERIGSTDDMITHASICTDKNFLYLILATASRQLRLVKLTLQWGPSQGDKQPISSPLSPTIVERHLASTSWHQYGPNDSAFDAAMTQVSHLEILPSTLENDAQSWSPPLILTVRSYLPSPDSPYPEAQSIIDRWQVLTDQPQTIHPAFSSLGGQKQNSVPDIQPTTRLQRGEPLTFNKVIVGLQILQFGKVICVAFSDGTVEYRDRLTLSEIYNEPNTERIMNPHQVGFAFPDPTPCLQLVLSPTNCSLVQITPDGELIWKYLQYAQGDIGNSTQDPQYSPVIAALTVATGAAIYYVSSFDDVLAVARPFADKKRFTYDFANDVVSMLKITVDYSEDSHHDNLVRNTHLQMCLSIIGNLGFHGQYDARTFGSKFATLALNARNIVILVTIASNTPPNLREKFSPLDEPEVVEALAGCAKWSIDLLSWLADCLFSLLDDPKFTSLVKDQSKFAAVSAYLQEKNDVALHLLLCSSTRGLLVAVCRRLQHLDTLGNRVIGYWETQQAQADGKAPNLSLHRAYQRMQQITSSSLVKAQEFEKLLTQLGADIRSTYSTMLTAMVSKAAGQPPPQAGAAISKHLDAAVKQAQMQCELGMLLGGTIHPMFRKALGQLFANHLAGFKVTVDPAKLFFHDYSLLEVAADSPESFAKKRAEAIYVDMFRKVEITPGQTEQQVDGGRVNGPVWSGQWRRCVRCASVMEDVSSPRPGFSYVLTQQRKCACGGSWGLLPKGELIS
Length976
PositionTail
OrganismLomentospora prolificans
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Microascales> Microascaceae> Lomentospora.
Aromaticity0.08
Grand average of hydropathy-0.166
Instability index43.71
Isoelectric point5.93
Molecular weight107935.65
Publications
PubMed=28963165

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP19198
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     142.08|      41|     418|      61|     102|       2
---------------------------------------------------------------------------
   61-  102 (72.24/59.64)	CCQTVAWSKAGIIASLTPDGHFVeLRFLRCNPDDGSWQLSEP
  481-  521 (69.83/52.50)	CLQLVLSPTNCSLVQITPDGELI.WKYLQYAQGDIGNSTQDP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     109.74|      35|     130|      11|      49|       3
---------------------------------------------------------------------------
   11-   49 (55.15/41.84)	SNGM..PFLENSLPavlPD.VDDLfGGEVPVN.LALSPPTKEL
  144-  182 (54.60/30.23)	SNAInrPYLTRRWD...PDpIDDL.NAVVGCHwLSLMPPSRQF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     373.74|     110|     453|     287|     398|       4
---------------------------------------------------------------------------
  287-  398 (192.05/140.03)	WGPSQGDKQPISSPLS.PTIVERHLASTSWHQYGPNDsaFDAAMTQV.....SHLEILPSTLENDAQSWSPPLI.LTVRSYLPSPDSP.YPEAQSIIDRWQV.....LTDQPQTI..HPAFSSLGGQ
  639-  688 (23.24/ 7.79)	......................................................................PP....NLREKFSPLDEPeVVEALAGCAKWSIdllswLADCLFSLldDPKFTSL...
  743-  853 (158.44/109.09)	WETQQAQADGKAPNLSlHRAYQRMQQITSSSLVKAQE..FEKLLTQLgadirSTYSTMLTAMVSKAAGQPPPQAgAAISKHL...DAA.VKQAQMQCELGML.....LGG...TI..HPMFRKALGQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.93|      24|     290|     245|     268|       5
---------------------------------------------------------------------------
  245-  268 (44.22/31.96)	IERIGSTDDMITHASICTDKN.FLY
  538-  562 (38.70/27.03)	IYYVSSFDDVLAVARPFADKKrFTY
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19198 with Med16 domain of Kingdom Fungi
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