<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19197
Description |
Mediator of RNA polymerase II transcription subunit 14 |
Sequence | MADVSAENGALTNHDRNTHLNGANGAGPKLTDTPNGTSKQTSDGGDSASLAVIDPTKQTFDPRRRMNDLPEEIVHIADGYIPLSILLSRLAQQTHNVLQEKVQQLARMPLPPAPAMNGNSSAPSKDEFDNSHESLSKKVNLLSFIQRIHGKWVKALVIANWSRESERVTKLIDLKSHLNNQLMQFDLRLDQVVELKRGLIFARVPSPDLKTALQVLSCGNGDWMPDLGYIEPPALKREDHVKWLEELDTCLSMRLNLHDYDKIPPQFKDYSIGSGRVTFSVKGEFEVDLTVADEDPEKQFWFIDFRFDFSPVAHDLTARFRPVLESHVNNALAKDNLTGCYQLLHGFVLTHKISELRRQAYELARTSWTRTLVVEQLDRAFSIQYWVTRQPQVTSSVPAYSRYAIPQVPTVPKSWIIVSAVSARRPDGNLDPKASSRLAVKWFRDGKEVKDVEIEFDQVNLSTEKLLKVVIAKHVEHILRSIHKKLRPAPRFAGQEAAMALRISASDAGESFLTMQLSATETVTLTVEPTSGKFNLHPNSKFTMQAESRLNMSGKDPAEDGAPCLETLRWHHLAEEIARKGRSQGWTPVKSPLSHEDVKALFKPQEQFSPVCFQRQGVDTRWYVMLVMSLHGDEWWVFRSDVPKATARSVKFFSKLRLQLGQPGLERAFWNNLTMFVTAVISHATDLAELHHNRFRYEKRANKNFSLPNEVVIPSIFIKLSDILPTAADQGEYALTLEDKHHRTPQLHIEPSKDGTSQSPTNNSDMAALPKSGAKRTPPGTRKPWAADFVELRYSGVQSIPSKDSASARQLTCSMDAIVRVLDRKKFSLLSGKLGHQVYYNPGRGEFCIRLRTRVGTSIVRTLTTRLQAIDRVVDSLDAMRSTKGAIKCEQVTLEKVIFTYTDAGGSDGAKRWRVSLDLSTESIAIDLEMGNPHLRVIDHLTSLVNAPGGISHLTLVLPMSLTILTILDKIQNAWKEIAKHGKGALIITPKALDWITLCYELPETPNRPRSVRIDVRARIRNGKLWWFVRRSDQEEQDFFAQRLRKVWEARNVPWRSLSSGAATHIDDRSLKLLIGLDQTVREAVLGTGTGPNAAANNAQASVGRVNAQAGTATTGGAAVGSRAKPVTLD |
Length | 1130 |
Position | Tail |
Organism | Lomentospora prolificans |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes>
Hypocreomycetidae> Microascales> Microascaceae> Lomentospora.
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Aromaticity | 0.07 |
Grand average of hydropathy | -0.376 |
Instability index | 40.92 |
Isoelectric point | 9.24 |
Molecular weight | 126386.61 |
Publications | PubMed=28963165
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU365082
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GO - Cellular Component | mediator complex GO:0016592 IEA:UniProtKB-UniRule
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:UniProtKB-UniRule
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
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Interaction
Repeat regions
Repeats |
>MDP19197
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 80.03| 24| 47| 486| 510| 1
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486- 510 (36.76/33.32) LRPAPRFAGQEAAMaLRISASDAGE
536- 559 (43.27/33.93) LHPNSKFTMQAESR.LNMSGKDPAE
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 69.66| 21| 390| 632| 657| 2
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632- 657 (36.05/33.00) GDEWW.VFRSDvpkatARSVKFFS.KLR
1023- 1045 (33.61/19.12) GKLWWfVRRSD.....QEEQDFFAqRLR
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 95.63| 31| 238| 28| 58| 3
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28- 58 (54.68/42.87) PKLTDTPNGTSKQT.SDGGD.SASLAVI..DPTKQ
265- 299 (40.96/29.87) PQFKDYSIGSGRVTfSVKGEfEVDLTVAdeDPEKQ
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 53.35| 15| 49| 809| 823| 4
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809- 823 (27.52/20.25) RQLTCSMDAIVRVLD
861- 875 (25.83/18.54) RTLTTRLQAIDRVVD
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 48.90| 15| 238| 518| 532| 7
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518- 532 (24.26/15.52) SATETVTLTVEPTSG
759- 773 (24.64/15.89) SPTNNSDMAALPKSG
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
4| 290.19| 103| 198| 140| 246| 8
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140- 182 (42.55/19.14) ............................................................................................................................................................NLLSFIQRIHGKWVKALVI....ANWSRESERVTKLIDLKSHLNNQL
183- 246 (73.06/52.91) MQFDL.RLDQVVelKRGLIFARVPSPDLKTALQ..VLSCGNGDWMPDlGYIEPPALKREdHVKWLEE........................................................................................................................................
336- 377 (39.37/17.09) ...................................................................ldtclsmrlnlhdydkippqfkdysigsgrvtfsvkgefevdltvadedpekqfwfidfrfdfspvahdltarfrpvleshvnnalakdNLTGCYQLLHG.FVLTHKI....SELRRQAYELARTSWTRTLVVEQL
383- 479 (135.22/79.91) IQYWVtRQPQVT..SSVPAYSRYAIPQVPTVPKswIIVSAVSARRPD.GNLDPKASSRL.AVKWFRD...................................................................................................GKEVKDVEIefdqVNLS..TEKLLKVV.IAKHVEHIL
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 190.27| 59| 635| 60| 120| 9
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60- 120 (96.18/76.40) FDPRRRMN.DLPEEIVhIADGYIPLSILLSRLAQQTHNVLQEKvQQLARMP.LPPAPAMNGNS
697- 757 (94.09/64.88) YEKRANKNfSLPNEVV.IPSIFIKLSDILPTAADQGEYALTLE.DKHHRTPqLHIEPSKDGTS
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