<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19197

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMADVSAENGALTNHDRNTHLNGANGAGPKLTDTPNGTSKQTSDGGDSASLAVIDPTKQTFDPRRRMNDLPEEIVHIADGYIPLSILLSRLAQQTHNVLQEKVQQLARMPLPPAPAMNGNSSAPSKDEFDNSHESLSKKVNLLSFIQRIHGKWVKALVIANWSRESERVTKLIDLKSHLNNQLMQFDLRLDQVVELKRGLIFARVPSPDLKTALQVLSCGNGDWMPDLGYIEPPALKREDHVKWLEELDTCLSMRLNLHDYDKIPPQFKDYSIGSGRVTFSVKGEFEVDLTVADEDPEKQFWFIDFRFDFSPVAHDLTARFRPVLESHVNNALAKDNLTGCYQLLHGFVLTHKISELRRQAYELARTSWTRTLVVEQLDRAFSIQYWVTRQPQVTSSVPAYSRYAIPQVPTVPKSWIIVSAVSARRPDGNLDPKASSRLAVKWFRDGKEVKDVEIEFDQVNLSTEKLLKVVIAKHVEHILRSIHKKLRPAPRFAGQEAAMALRISASDAGESFLTMQLSATETVTLTVEPTSGKFNLHPNSKFTMQAESRLNMSGKDPAEDGAPCLETLRWHHLAEEIARKGRSQGWTPVKSPLSHEDVKALFKPQEQFSPVCFQRQGVDTRWYVMLVMSLHGDEWWVFRSDVPKATARSVKFFSKLRLQLGQPGLERAFWNNLTMFVTAVISHATDLAELHHNRFRYEKRANKNFSLPNEVVIPSIFIKLSDILPTAADQGEYALTLEDKHHRTPQLHIEPSKDGTSQSPTNNSDMAALPKSGAKRTPPGTRKPWAADFVELRYSGVQSIPSKDSASARQLTCSMDAIVRVLDRKKFSLLSGKLGHQVYYNPGRGEFCIRLRTRVGTSIVRTLTTRLQAIDRVVDSLDAMRSTKGAIKCEQVTLEKVIFTYTDAGGSDGAKRWRVSLDLSTESIAIDLEMGNPHLRVIDHLTSLVNAPGGISHLTLVLPMSLTILTILDKIQNAWKEIAKHGKGALIITPKALDWITLCYELPETPNRPRSVRIDVRARIRNGKLWWFVRRSDQEEQDFFAQRLRKVWEARNVPWRSLSSGAATHIDDRSLKLLIGLDQTVREAVLGTGTGPNAAANNAQASVGRVNAQAGTATTGGAAVGSRAKPVTLD
Length1130
PositionTail
OrganismLomentospora prolificans
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Microascales> Microascaceae> Lomentospora.
Aromaticity0.07
Grand average of hydropathy-0.376
Instability index40.92
Isoelectric point9.24
Molecular weight126386.61
Publications
PubMed=28963165

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP19197
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.03|      24|      47|     486|     510|       1
---------------------------------------------------------------------------
  486-  510 (36.76/33.32)	LRPAPRFAGQEAAMaLRISASDAGE
  536-  559 (43.27/33.93)	LHPNSKFTMQAESR.LNMSGKDPAE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.66|      21|     390|     632|     657|       2
---------------------------------------------------------------------------
  632-  657 (36.05/33.00)	GDEWW.VFRSDvpkatARSVKFFS.KLR
 1023- 1045 (33.61/19.12)	GKLWWfVRRSD.....QEEQDFFAqRLR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.63|      31|     238|      28|      58|       3
---------------------------------------------------------------------------
   28-   58 (54.68/42.87)	PKLTDTPNGTSKQT.SDGGD.SASLAVI..DPTKQ
  265-  299 (40.96/29.87)	PQFKDYSIGSGRVTfSVKGEfEVDLTVAdeDPEKQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.35|      15|      49|     809|     823|       4
---------------------------------------------------------------------------
  809-  823 (27.52/20.25)	RQLTCSMDAIVRVLD
  861-  875 (25.83/18.54)	RTLTTRLQAIDRVVD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.90|      15|     238|     518|     532|       7
---------------------------------------------------------------------------
  518-  532 (24.26/15.52)	SATETVTLTVEPTSG
  759-  773 (24.64/15.89)	SPTNNSDMAALPKSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     290.19|     103|     198|     140|     246|       8
---------------------------------------------------------------------------
  140-  182 (42.55/19.14)	............................................................................................................................................................NLLSFIQRIHGKWVKALVI....ANWSRESERVTKLIDLKSHLNNQL
  183-  246 (73.06/52.91)	MQFDL.RLDQVVelKRGLIFARVPSPDLKTALQ..VLSCGNGDWMPDlGYIEPPALKREdHVKWLEE........................................................................................................................................
  336-  377 (39.37/17.09)	...................................................................ldtclsmrlnlhdydkippqfkdysigsgrvtfsvkgefevdltvadedpekqfwfidfrfdfspvahdltarfrpvleshvnnalakdNLTGCYQLLHG.FVLTHKI....SELRRQAYELARTSWTRTLVVEQL
  383-  479 (135.22/79.91)	IQYWVtRQPQVT..SSVPAYSRYAIPQVPTVPKswIIVSAVSARRPD.GNLDPKASSRL.AVKWFRD...................................................................................................GKEVKDVEIefdqVNLS..TEKLLKVV.IAKHVEHIL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     190.27|      59|     635|      60|     120|       9
---------------------------------------------------------------------------
   60-  120 (96.18/76.40)	FDPRRRMN.DLPEEIVhIADGYIPLSILLSRLAQQTHNVLQEKvQQLARMP.LPPAPAMNGNS
  697-  757 (94.09/64.88)	YEKRANKNfSLPNEVV.IPSIFIKLSDILPTAADQGEYALTLE.DKHHRTPqLHIEPSKDGTS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19197 with Med14 domain of Kingdom Fungi
Unable to open file!