<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19195

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMADPALALERVLHARLSDEGDALHSLLERKQALLDVQADGGRVFVPRSTPQDAARAQRMRLWAERGEFKKVRSAHLVDECEEAEAPLFEQLRSLDAPEATPAPSAPEERTGRISEQEFFPFRDTLLHQLESALFNAEQAQNLLGMLIHNARAASGASNTAVLAAQPDYFLEPQAIALSRLQRSEEEEGVRISSPTAHAKKAVLEMKVQSLQTAASVLEQGSAQLVQCAAPEKARWQALRDIQKRGWKLTPGRPLLDIERFDVGARKDALQGFGIPVLHGDGALNEEGARDAWIGYGPAEAPVELLQRTMAYWADAQGAQRARLAFPDRTRRRLRVSFHSHGQDAQVWSSLRDAPLDEHASLDAQLYDAQMDAVDTELFRELAAQSGVLAPVFARIVSESSVLLPLSTELDVRIELVEHDAPLAPGVQTSPLPSLLLAVLRLRMLRSWSLHSTRLRAAQVDQARAAEPRANVTGPVWELYKYTLYLARLRTVLDRVVGTRATYQWKPYEMIVDMQAWITSLVDLAEDPDATEPTTGGLVLVYRSETLAAQLTVRAPSHLIVFFPQHRTPSGVGLRLALELDQLEPLLAAALDELP
Length594
PositionHead
OrganismMalassezia vespertilionis
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Ustilaginomycotina> Malasseziomycetes> Malasseziales> Malasseziaceae> Malassezia.
Aromaticity0.06
Grand average of hydropathy-0.233
Instability index45.05
Isoelectric point5.41
Molecular weight65711.82
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP19195
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      93.37|      22|      27|     314|     338|       1
---------------------------------------------------------------------------
   52-   73 (31.70/13.64)	DAARAQRMRL.WAERGEfKKVR...S
   95-  112 (26.26/ 9.39)	DAPEATPAPSAPEERTG.R.......
  314-  338 (35.40/22.88)	DAQGAQRARLAFPDRTR.RRLRvsfH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.98|      24|      31|     375|     405|       2
---------------------------------------------------------------------------
  375-  404 (31.34/37.30)	TEL.FR.ELAAQSGVLAPVfariVSESSvlLP
  407-  432 (35.64/18.32)	TELdVRiELVEHDAPLAPG....VQTSP..LP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.39|      20|      21|     253|     273|       3
---------------------------------------------------------------------------
  253-  273 (33.11/23.93)	PLL..DIERFDVGARkDALQGFG
  275-  296 (34.28/20.15)	PVLhgDGALNEEGAR.DAWIGYG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.57|      22|     358|     162|     184|       4
---------------------------------------------------------------------------
  162-  184 (34.44/20.27)	LAAQPDYfLEPQAIALSRLQRSE
  523-  544 (37.13/17.64)	LAEDPDA.TEPTTGGLVLVYRSE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.77|      25|      31|     449|     479|       9
---------------------------------------------------------------------------
  449-  479 (30.15/30.70)	LHSTRLRAAqVDqaRAAEPRANVTgpvWELY
  483-  507 (45.62/23.77)	LYLARLRTV.LD..RVVGTRATYQ...WKPY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19195 with Med17 domain of Kingdom Fungi
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