<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19192

Description Multifunctional fusion protein
SequenceMIPPVPEPEPETILLVHALAGGTLPWDSKCAITHALLETRLAYANSDLGDVRLAFYAELLVAMAHAACICLQADTETGSAWRAIIGGVLPPLFLYLERLYASVQPVQLTLEGVITAFIELHPPVAHWAELERVQGPMLREHIIQCMDAYGLLAIEHSAWAAQQGPVKPDDIVHGASTDVLQYMQRVETQIEARGALAPLAVQASTDPTRQLCFAHVITKKLLAWAAGGAEMERVAALCDALAQRGVCDALLLYCTRGMLTRTLLLIIEQLNESQWQDGVALEWIADVLLLTQRLAKGDMAACLAAAPQSMRLFLLHDKTPVVVGGALCDSSGALLERWCAALVGSDGVSDELLQASSPKTMYQLAPAITYLLIEAHALKLIDKSALHSALSYFLQAPLRYTLPCILFWLMQQVRRSLATAVYLQLADVHLEMLLALFRAASFPDTVRTILREPMLDLLQHERIASHPDAAPIHAQLEQAALPRPIVWPCGALEKAIAFNAQYERHAADAALVYTGDLGNRTYLALAAIQHMDTKSTRLLAAVLAMALPQPPLQWSTSHLAILIVRAWNTAAATHKEIQNMAHVMVASAVLAWQMRDGVAAVQLLAETLANIADHSPPSQSSQLVWFASMNPIDFKVDNFSIICTIGPKTNTIPMLHKLRNTGMNIGTHGTHEYFQSVIDNSHQVEREAPGRPLAFALDTKGPEMRTGVMIDEKDVNVEEGHEFIVTTDEKYADKCSAEHLYIDYKKLPQMVKPDRIIYIDDGILALRVLSIEGTDVHVVSINNGTLSSRKGVNLPLTEVDLPAVSDKDRRDLEFAREHQLDMVFASFIRSKNDIITIREILGEKGAHIRIIAKIENHQGLQNFDEILDAADGIMVARGDLGIEIPAPQVFLAQKMIISRCNIVGKPVICATQMLESMTVNNRPTRAEVSDVANAVVDGADCVMLSGETAKGMYPTEAVKMMAETTYIAEQTLAYQALFNEMRALTRVPTNTNETIALVAVSASLEQKAGAILLMSTSGNTARLVSKYKPQCPILMVTRNAYTARSCHLYRGTYPFHYPLPHPDHNSKWQEDVDNRVKFGLSEALKLHIIRKDDVVIAIQGWRGGKGHTNSLRILTVPSSTEGYMLEDTTATV
Length1132
PositionTail
OrganismMalassezia vespertilionis
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Ustilaginomycotina> Malasseziomycetes> Malasseziales> Malasseziaceae> Malassezia.
Aromaticity0.06
Grand average of hydropathy0.092
Instability index37.21
Isoelectric point5.75
Molecular weight124362.44
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-KW
kinase activity	GO:0016301	IEA:UniProtKB-KW
magnesium ion binding	GO:0000287	IEA:InterPro
potassium ion binding	GO:0030955	IEA:InterPro
pyruvate kinase activity	GO:0004743	IEA:UniProtKB-EC
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP19192
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     106.99|      34|      63|     524|     559|       1
---------------------------------------------------------------------------
  524-  557 (61.05/40.76)	ALAAIQHMD.TKSTRLLAAVLA.MALPQPPLQ.....WSTS
  588-  628 (45.94/22.89)	AVLAWQMRDgVAAVQLLAETLAnIADHSPPSQssqlvWFAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     200.61|      67|      69|     881|     949|       3
---------------------------------------------------------------------------
  881-  949 (103.93/74.67)	GIeIPAPQV.FLAQKMIISRCNIVGKPVICATQMLESMTVNNRPTRAEVSdVANAVVDGADCVML...SGETA
  951- 1021 (96.69/60.78)	GM.YPTEAVkMMAETTYIAEQTLAYQALFNEMRALTRVPTNTNETIALVA.VSASLEQKAGAILLmstSGNTA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     118.71|      23|      62|     158|     180|       4
---------------------------------------------------------------------------
  127-  151 (28.33/13.90)	.WAELervQGPMLREHIIQCMDAY..............GL
  158-  180 (40.43/22.91)	AWAAQ...QGPVKPDDIVHGASTD..............VL
  188-  222 (19.09/ 7.01)	TQIEA...RGALAP..LAVQASTDptrqlcfahvitkkLL
  223-  241 (30.85/15.78)	AWAA.....GGAEMERV..AALCD..............AL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19192 with Med5 domain of Kingdom Fungi
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