<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19189

Description Srb8p
SequenceMAEHGPMLEPYTLAAPPWRPSMHTDVSLGYPGIWAPTQAEELTSQAVRSGVTFVPPVLNESTSVQEQIYERLSRPGSIHLLNTLVNGVRDVRRARRAADITAHEFRLPPRVTLNDGKLAAYVRALSDPLVPLAHLARGLPYGFRGMKLLDMLWQGPQPEVGVASWRQNYTGQGIPIPRAMWFIHAIGACEVQTQKCSAVHYTEDWTAAVLAWLTQQLDVLPHDEAAEQGAIPGVQDASVVHWTNKWSYALALVQAMRSDSLLADDAYLRWVVTQLHASQGCTRACMLQIVCTVYKDLLARACLGVNLIAALSTPHTSPTRAWFAEQEASLLRRCYETEPRAFVGMHLWTPTSRLPVLLGTLEAPFYPPEAAQSRLLEGALAPLLASSRTDSAVAWDAVAIHLLDTGEQDTTTLFLRYFLPPGMLPDVERRVSLLLTWACTLDRDYPGRVYIAVELVRLFDACQNNRLVLHDGRHVAWPAQRYALFDTIARWIDTIESADAPAHANAELGALSLPSVARLLGALCSANLFSFVRFFQRLQLRGTVCLETDAPRTQRTRTHIHARIFCSMPIHHVSDTVVQQRRVAIYGQCAAQSYEEATEQRAFREVSQTFPWLCHALPEEEHIASPASAPPPSPAAMAPPDMPALPASPSFPDNASPVLDALQLRQKVPYLLSASPYVQDRIAQRIGPVLTSETARAPTADEFCEIASMLCAIEALSTLANLCLALLDRHVEPSCVVSVCHILAAHSRTWDALRITDALAAHVAPHAVHDSSAPGTSVRVVHSRGRSMAVASARGALNAMGRGDLEEKLMPARPVHATMLAAAHAPSRALLCGTSGEALDAACAALLATVPLDDAPNALWQHALDMASAPDAQPFSPAIVACIAAVAGAAGVRLAVRDWIRKRYALDGGAAAPASTAWCALVAGMVRFGHLELDSLLHTLSDFVAEHRDATTHMFWSACVALSDTLFCAHSSSACGIATVGVATWHDLVLQRDMLVRRNALMPWVLAVRHAPSLAARLAPHAEWLRLQWRTHPGAFLHGTDAASEHVLRAAHVWSASVLLRHGTPDQIADALERVSPCDAAWSLAELRLVLDTVEPARLAELVESLMPCLLPAPAALQGARDELLFGFGAQRMVHDALASTALRRWVAAPDEEQGAVYIHAMVRLAHAWRGELYCDEAILLDALRALDKALDAAHEPLAVLLFVLRCDAWRANGVFSQALRAALLQLLPRLLRLCEEAGGAMAELLEACTVQVELAVGAEALAAWLPTAPHVPPRLQRLVEHASLPLHAWQRFDALGNPPPPPTRDPWAVPLENCGALPLEVCDTCKTRDGVPNTGERSAPPLWLTSEQTYGDMDNMPLGAQTIAMA
Length1367
PositionKinase
OrganismMalassezia vespertilionis
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Ustilaginomycotina> Malasseziomycetes> Malasseziales> Malasseziaceae> Malassezia.
Aromaticity0.07
Grand average of hydropathy0.090
Instability index50.55
Isoelectric point6.00
Molecular weight148710.17
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP19189
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.05|      30|      39|     194|     225|       1
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  194-  225 (48.14/38.24)	QKCSAVHYTEDWTAAvLAwLTQQL..DVLPHDEA
  235-  266 (52.91/31.09)	QDASVVHWTNKWSYA.LA.LVQAMrsDSLLADDA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     147.53|      34|      34|    1065|    1098|       2
---------------------------------------------------------------------------
 1045- 1064 (22.07/ 6.30)	....................EHVLRA....AHVWSAS...VL...L....RHGT
 1065- 1098 (58.88/30.18)	PD............QIADALERVSPC....DAAWSLAELRLV...LDTV.EPAR
 1099- 1132 (37.92/16.58)	L...............AELVESLMPCllpaPAALQGARDELL...FG.F.GAQR
 1150- 1197 (28.67/10.58)	PDeeqgavyihamvRLAHAWRGELYC....DEAILLDALRALdkaLDAAhEP..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     456.23|     120|     123|     779|     901|       3
---------------------------------------------------------------------------
  614-  665 (33.88/ 9.32)	...............................................................................................CHAL.........PEE..EHIA....SPASAP...PPSPAAMAppdmpALPASPSfpdnASPVLDALQ...LR
  681-  777 (93.75/41.08)	RIAQRIGPVLTSETARaptadefceiasmlcaiealSTLANLCL.ALLD.RHVEPS........CVVSVCHI.LAAHSRTWDALRIT..DALAAHVAP................HAV....HDSSAPGTS......................................
  779-  901 (204.84/105.71)	RVVHSRGRSMAVASAR....................GALNAMGR.GDLE.EKLMPA........RPVHATML.AAAHAPSRALLCGTSGEALDAACAALLATVPLddaPNALWQHAL....DMASAPDAQPFSPAIVA.....CIAAVAG....AAGVRLAVR.DWIR
  920- 1026 (123.75/57.00)	ALV....................................AGMVRfGHLElDSLLHTlsdfvaehRDATTHMFwSACVALSDTLFCAHSS....SACG..IATVGV.....ATW.HDLvlqrDMLVRRNA..LMPWVLA.....VRHAPSL....AA..RLAPHaEWLR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.68|      18|     145|     291|     308|       4
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  291-  308 (31.92/19.25)	CTVYKDLLARACLGVNLI
  439-  456 (32.76/19.95)	CTLDRDYPGRVYIAVELV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     102.14|      26|     116|     376|     418|       6
---------------------------------------------------------------------------
  393-  418 (46.43/15.81)	VAWDAVAIHLLDTGEQDTTTLFLRYF
  475-  487 (15.31/21.28)	VAWPAQRYALFDT.............
  511-  535 (40.40/11.80)	LSLPSVA.RLLGALCSANLFSFVRFF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     147.21|      46|     226|     314|     374|      13
---------------------------------------------------------------------------
  314-  374 (72.09/48.02)	PHTSPTRawfaeqeasllrrcYETEPRAFVGM..HLWTPT...SRLPVLLGTLEAPFYpPEAAQSR
  551-  601 (75.12/41.55)	PRTQRTR..............THIHARIFCSMpiHHVSDTvvqQRRVAIYGQCAAQSY.EEATEQR
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19189 with Med12 domain of Kingdom Fungi
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